Ageing related thyroid deficiency increases brain-targeted transport of liver-derived ApoE4-laden exosomes leading to cognitive impairment

Autor: Manman Zhang, Wenliang Gong, Dianjun Zhang, Ming Ji, Binjie Chen, Beina Chen, Xinyu Li, Yuefei Zhou, Chengyi Dong, Gehua Wen, Xiaoni Zhan, Xiafang Wu, Lulu Cui, Yuliang Feng, Siman Wang, Huiya Yuan, Enyu Xu, Maosheng Xia, Alexei Verkhratsky, Baoman Li

Publikováno v: Cell Death and Disease, Vol 13, Iss 4, Pp 1-13 (2022)

Abstract Alzheimer’s disease (AD) is the prevalent cause of dementia in the ageing world population. Apolipoprotein E4 (ApoE4) allele is the key genetic risk factor for AD, although the mechanisms linking ApoE4 with neurocognitive impairments and a

Externí odkaz: https://doaj.org/article/65bdf297afbe42b08017942323a01017

Iron induces two distinct Ca2+ signalling cascades in astrocytes

Autor: Wenzheng Guan, Maosheng Xia, Ming Ji, Beina Chen, Shuai Li, Manman Zhang, Shanshan Liang, Binjie Chen, Wenliang Gong, Chengyi Dong, Gehua Wen, Xiaoni Zhan, Dianjun Zhang, Xinyu Li, Yuefei Zhou, Dawei Guan, Alexei Verkhratsky, Baoman Li

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)

Wenzheng Guan and Maosheng Xia et al. use a combination of pharmacological, genetic, and calcium imaging approaches to describe two mechanisms of iron-induced astrocytic calcium signaling. Altogether, these results suggest that astrocytes may act as

Externí odkaz: https://doaj.org/article/a67c1f1c03484bec8f4a7b5d8d413b09

The neuroprotective mechanism of lithium after ischaemic stroke

Autor: Xinyu Li, Baoman Li, Ming Ji, Wenliang Gong, Huiya Yuan, Alexei Verkhratsky, Benjie Chen, Maosheng Xia, Manman Zhang, Beina Chen, Chengyi Dong, Yuefei Zhou, Xiafang Wu, Dianjun Zhang, Gehua Wen, Enyu Xu, Xiaoni Zhan

Publikováno v: Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)

Stroke causes degeneration and death of neurones leading to the loss of motor function and frequent occurrence of cognitive impairment and depression. Lithium (Li+), the archetypal mood stabiliser, is neuroprotective in animal models of stroke, albei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e27644af164674d303d19b35c2e6e38
https://doi.org/10.1038/s42003-022-03051-2

Ageing related thyroid deficiency increases brain-targeted transport of liver-derived ApoE4-laden exosomes leading to cognitive impairments

Autor: Alexei Verkhratsky, Manman Zhang, Yuefei Zhou, Dianjun Zhang, Chengyi Dong, Maosheng Xia, Binjie Chen, Wenliang Gong, Baoman Li, Xiaoni Zhan, Xiafang Wu, Xinyu Li, Beina Chen, Gehua Wen, Ming Ji

Alzheimer's disease (AD) is the prevalent cause of dementia in the ageing world population. Apolipoprotein E4 (ApoE4) allele is the key genetic risk factor for AD, although the mechanisms linking APOE4 with neurocognitive impairments and aberrant met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ace83a949d7b86632fa835aa10151e9
https://doi.org/10.21203/rs.3.rs-757423/v1

The Association Between Antidepressant Effect of SSRIs and Astrocytes: Conceptual Overview and Meta‐analysis of the Literature

Autor: Wenliang Gong, Robert Zorec, Baoman Li, Matjaž Stenovec, Beina Chen, Binjie Chen, Alexei Verkhratsky, Manman Zhang, Ming Ji

Publikováno v: Chen, B, Zhang, M, Ji, M, Gong, W, Chen, B, Zorec, R, Stenovec, M, Verkhratsky, A & Li, B 2021, ' The Association Between Antidepressant Effect of SSRIs and Astrocytes: Conceptual Overview and Meta-analysis of the Literature ', Neurochemical research . https://doi.org/10.1007/s11064-020-03225-6

Major depressive disorders (MDD) a worldwide psychiatric disease, is yet to be adequately controlled by therapies; while the mechanisms of action of antidepressants are yet to be fully characterised. In the last two decades, an increasing number of s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3cd696566b589166cf54b2bc6c06def
https://doi.org/10.1007/s11064-020-03225-6