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Akademický článek

Proprotein Convertase Subtilisin/Kexin Type 9 Promotes Gastric Cancer Metastasis and Suppresses Apoptosis by Facilitating MAPK Signaling Pathway Through HSP70 Up-Regulation

Autor: Beili Xu, Shuyu Li, Yong Fang, Yanting Zou, Dongqiang Song, Shuncai Zhang, Yu Cai

Publikováno v: Frontiers in Oncology, Vol 10 (2021)

ObjectiveTo examine the effect of proprotein convertase subtilisin/kexin type 9 (PCSK9) on gastric cancer (GC) progression and prognosis, and to explore the underlying mechanism.MethodsPCSK9 expression levels in human GC tissues were determined by qu

Externí odkaz: https://doaj.org/article/b0a22f017df74ce8b3e646e8f2fc172d

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Akademický článek

Morin Hydrate Inhibits TREM-1/TLR4-Mediated Inflammatory Response in Macrophages and Protects Against Carbon Tetrachloride-Induced Acute Liver Injury in Mice

Autor: Xi Li, Qunyan Yao, Jiying Huang, Qianwen Jin, Beili Xu, Fangyuan Chen, Chuantao Tu

Publikováno v: Frontiers in Pharmacology, Vol 10 (2019)

This study aims to investigate the protective effects of morin hydrate (MH) against acute liver injury induced by carbon tetrachloride (CCl4) in mice and to elucidate the possible molecular mechanism of action. Mice were pretreated with MH (50 mg/kg

Externí odkaz: https://doaj.org/article/25c97b28214b421798055f7aca679756

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Akademický článek

The Flavonoid Quercetin Ameliorates Liver Inflammation and Fibrosis by Regulating Hepatic Macrophages Activation and Polarization in Mice

Autor: Xi Li, Qianwen Jin, Qunyan Yao, Beili Xu, Lixin Li, Shuncai Zhang, Chuantao Tu

Publikováno v: Frontiers in Pharmacology, Vol 9 (2018)

At present, there are no effective antifibrotic drugs for patients with chronic liver disease; hence, the development of antifibrotic therapies is urgently needed. Here, we performed an experimental and translational study to investigate the potentia

Externí odkaz: https://doaj.org/article/26a7bc68b52546fb8ab9039308afe81c

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The Current Status and Influencing Factors of the Layout of Cold Storage and Precooling Facilities for Fruit and Vegetable Agricultural Products in Producing Area of Hunan Province

Autor: Beili Xu, Yan Pang

Publikováno v: 12th International Conference on Logistics and Systems Engineering 2023.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::18ea353406bc83462197585616a18193
https://doi.org/10.52202/068701-0018

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S100A6 promotes proliferation and migration of HepG2 cells via increased ubiquitin-dependent degradation of p53

Autor: Dongmin Shi, Beili Xu, Yu Cai, Shuyu Li, Dongqiang Song

Publikováno v: Open Medicine
Open Medicine, Vol 15, Iss 1, Pp 317-326 (2020)

Purpose S100A6 protein (calcyclin), a small calcium-binding protein of the S100 family, is often upregulated in various types of cancers, including hepatocellular carcinoma (HCC). The aim of this study was to illustrate the molecular mechanism of S10

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::961c4fcf0cd84834407009de7e12880a
https://doi.org/10.1515/med-2020-0101

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Proprotein Convertase Subtilisin/Kexin Type 9 Promotes Gastric Cancer Metastasis and Suppresses Apoptosis by Facilitating MAPK Signaling Pathway Through HSP70 Up-Regulation

Autor: Yong Fang, Beili Xu, Dongqiang Song, Yu Cai, Yanting Zou, Shuncai Zhang, Shuyu Li

Publikováno v: Frontiers in Oncology, Vol 10 (2021)
Frontiers in Oncology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21052840d443f9b1f6d7e1f127fce3d3
https://www.frontiersin.org/articles/10.3389/fonc.2020.609663/full

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Placental growth factor silencing ameliorates liver fibrosis and angiogenesis and inhibits activation of hepatic stellate cells in a murine model of chronic liver disease

Autor: Xi Li, Shuncai Zhang, Chuantao Tu, Beili Xu, Qunyan Yao, Hongchun Liu, Qianwen Jin

Publikováno v: Journal of Cellular and Molecular Medicine

Placental growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family and is involved in pathological angiogenesis associated with chronic liver diseases. However, the precise mechanisms underlying PlGF signalling contrib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b0a520fe2daa10ea804983a935e093c
http://europepmc.org/articles/PMC5618674

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Inhibition of Proprotein Convertase Subtilisin/Kexin Type 9 Ameliorates Liver Fibrosis via Mitigation of Intestinal Endotoxemia

Autor: Beili Xu, Yu Cai, Shuncai Zhang, Hongying Guo, Yanting Zou, Shuyu Li

Publikováno v: Inflammation. 43(1)

Lipopolysaccharide (LPS) is demonstrated to cause "two-hit" injury to liver. Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays an important role in LPS clearance. Hepatocyte nuclear factor-1 alpha (HNF-1α) and sterol regulatory element-bin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c77f61ebb132c435e06e73ab1554370
https://pubmed.ncbi.nlm.nih.gov/31776890

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