Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Beili WU"'
Publikováno v:
环境与职业医学, Vol 40, Iss 8, Pp 981-988 (2023)
By the end of 2021, a total of 915000 cases of occupational pneumoconiosis and 450000 existing cases have been reported nationwide. Silicosis is a common and serious pneumoconiosis disease caused by long-term inhalation of large amounts of free silic
Externí odkaz:
https://doaj.org/article/1bdc6510dd2d4a839170a42a051dfcb2
Autor:
Wenli Zhao, Wenru Zhang, Mu Wang, Minmin Lu, Shutian Chen, Tingting Tang, Gisela Schnapp, Holger Wagner, Albert Brennauer, Cuiying Yi, Xiaojing Chu, Shuo Han, Beili Wu, Qiang Zhao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Neuromedin U receptor 2 is an emerging attractive target for treating obesity. Here, a Cryo-EM structure of NmU-25–NMU2–Gi1 provides the structural basis for the designation of highly selective drugs.
Externí odkaz:
https://doaj.org/article/524339c45ef44768b5d1ca4b8faaca2f
Autor:
Ya Zhu, Xiaowen Lin, Xin Zong, Shuo Han, Mu Wang, Yuxuan Su, Limin Ma, Xiaojing Chu, Cuiying Yi, Qiang Zhao, Beili Wu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
The formyl peptide receptor 2 (FPR2) is involved in the pathogenesis of Alzheimer’s disease. Structures of FPR2 bound to Aβ42, humanin, or formyl peptides offer insight into Aβ42 neurotoxicity, humanin neuroprotection, and FPR ligand selectivity
Externí odkaz:
https://doaj.org/article/b2f02e9c7808444689a37f350ad3b74f
Autor:
Fenghui Zhao, Qingtong Zhou, Zhaotong Cong, Kaini Hang, Xinyu Zou, Chao Zhang, Yan Chen, Antao Dai, Anyi Liang, Qianqian Ming, Mu Wang, Li-Nan Chen, Peiyu Xu, Rulve Chang, Wenbo Feng, Tian Xia, Yan Zhang, Beili Wu, Dehua Yang, Lihua Zhao, H. Eric Xu, Ming-Wei Wang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Multi-targeting agonists at GIPR, GLP-1R or GCGR are pursued vigorously. Here, the authors report cryo-EM structures of tirzepatide-bound GIPR and GLP-1R, peptide 20-bound GIPR, GLP-1R and GCGR, revealing the molecular basis of their multiplexed phar
Externí odkaz:
https://doaj.org/article/641f94f40fa443e4a6c8bf6fd15fb04c
Autor:
Hui Zhang, Kun Chen, Qiuxiang Tan, Qiang Shao, Shuo Han, Chenhui Zhang, Cuiying Yi, Xiaojing Chu, Ya Zhu, Yechun Xu, Qiang Zhao, Beili Wu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The chemokine receptor CCR5 plays multiple roles in the immune system. Here, structures of Gi1 protein-coupled CCR5 with or without a chemokine bound and of the CCR5- chemokine MIP-1 α complex offer insight into the distinct binding modes of the lig
Externí odkaz:
https://doaj.org/article/ffd3451ed1a64d6295cce87f44f382f2
Autor:
Tingting Tang, Christin Hartig, Qiuru Chen, Wenli Zhao, Anette Kaiser, Xuefeng Zhang, Hui Zhang, Honge Qu, Cuiying Yi, Limin Ma, Shuo Han, Qiang Zhao, Annette G. Beck-Sickinger, Beili Wu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
The human neuropeptide Y receptor Y2 (Y2R) is a drug target for the treatment of obesity and anxiety. Crystal structure of Y2R bound to a selective antagonist and accompanying mutagenesis provide insights into ligand recognition and subtype specifici
Externí odkaz:
https://doaj.org/article/a7b5b9da2b7f453a828d4e919ce3ab01
Autor:
Tong Chen, Muya Xiong, Xin Zong, Yunjun Ge, Hui Zhang, Mu Wang, Gye Won Han, Cuiying Yi, Limin Ma, Richard D. Ye, Yechun Xu, Qiang Zhao, Beili Wu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Formyl peptide receptors (FPRs) are GPCRs that play important roles in transducing chemotactic signals in phagocytes and mediating host-defense and inflammatory responses. Here the authors present the 2.8 Å crystal structure of human FPR2 in complex
Externí odkaz:
https://doaj.org/article/6a6c3a3f8432461e92e7060e4f1bd1bd
Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography
Autor:
Shuanghong Chen, Mengjie Lu, Dongsheng Liu, Lingyun Yang, Cuiying Yi, Limin Ma, Hui Zhang, Qing Liu, Thomas M. Frimurer, Ming-Wei Wang, Thue W. Schwartz, Raymond C. Stevens, Beili Wu, Kurt Wüthrich, Qiang Zhao
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
The FDA approved drug aprepitant is an antagonist of the Neurokinin 1 receptor (NK1R). Here the authors present aprepitant bound NK1R crystal structures and use NMR spectroscopy to gain further insights into the dynamics of aprepitant binding, which
Externí odkaz:
https://doaj.org/article/1fea1939297743138267a644666827c0
Autor:
Leqiang Sun, Yajie Tang, Keji Yan, Jinsong Yu, Yanyan Zou, Weize Xu, Ke Xiao, Zhihui Zhang, Weiming Li, Beili Wu, Zhe Hu, Kening Chen, Zhen F. Fu, Jinxia Dai, Gang Cao
Publikováno v:
Molecular Neurodegeneration, Vol 14, Iss 1, Pp 1-24 (2019)
Abstract Background Neurotropic virus-based tracers have been extensively applied in mapping and manipulation of neural circuits. However, their neurotropic and neurotoxic properties remain to be fully characterized. Methods Through neural circuit tr
Externí odkaz:
https://doaj.org/article/c929e778580345dab7c942c179f66e21
Autor:
Kayan Tam, Megan Schultz, Tamara Reyes-Robles, Bénédicte Vanwalscappel, Joshua Horton, Francis Alonzo, Beili Wu, Nathaniel R. Landau, Victor J. Torres
Publikováno v:
mBio, Vol 7, Iss 6 (2016)
ABSTRACT Leukocidin ED (LukED) is a bicomponent pore-forming toxin produced by Staphylococcus aureus that lyses host cells by targeting the chemokine receptors CC chemokine receptor type 5 (CCR5), CXCR1, CXCR2, and DARC. In addition to its role as a
Externí odkaz:
https://doaj.org/article/2d3a8571d04d47e2af728faf7069e218