Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Beijing K. Huang"'
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Current sensors for intracellular H2O2 are not sensitive enough to detect all biologically relevant H2O2 fluctuations. Here the authors develop a peroxiredoxin-2-based FRET probe that is sensitive enough to measure changes in H2O2 concentration in re
Externí odkaz:
https://doaj.org/article/1ada60e3af9c4daab6f468fb7f0175c1
Autor:
Beijing K. Huang, Hadley D. Sikes
Publikováno v:
Redox Biology, Vol 2, Iss C, Pp 955-962 (2014)
Molecular level, mechanistic understanding of the roles of reactive oxygen species (ROS) in a variety of pathological conditions is hindered by the difficulties associated with determining the concentration of various ROS species. Here, we present an
Externí odkaz:
https://doaj.org/article/57d65cdf71674e15bbea5079ca14a572
Publikováno v:
ACS Synthetic Biology. 5:1389-1395
Reactive oxygen species (ROS) such as H2O2 play paradoxical roles in mammalian physiology. It is hypothesized that low, baseline levels of H2O2 are necessary for growth and differentiation, while increased intracellular H2O2 concentrations are associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c813408abdcac455eb45f0e81f231c24
https://doi.org/10.1021/acssynbio.6b00120
https://doi.org/10.1021/acssynbio.6b00120
Publikováno v:
Antioxidants & Redox Signaling. 24:924-938
Aims: Chemotherapeutics target vital functions that ensure survival of cancer cells, including their increased reliance on defense mechanisms against oxidative stress compared to normal cells. Many chemotherapeutics exploit this vulnerability to oxid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f92624e29d109030ee0155d6e388ecb
https://doi.org/10.1089/ars.2015.6482
https://doi.org/10.1089/ars.2015.6482
Publikováno v:
Free Radical Biology and Medicine. 89:47-53
Hydrogen peroxide (H2O2) acts as a signaling molecule via its reactions with particular cysteine residues of certain proteins. Determining the roles of direct oxidation by H2O2 versus disulfide exchange reactions (i.e. relay reactions) between oxidiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb1f72d0df81b3b006060a10ca656a93
https://doi.org/10.1016/j.freeradbiomed.2015.07.009
https://doi.org/10.1016/j.freeradbiomed.2015.07.009
Interpreting Heterogeneity in Response of Cells Expressing a Fluorescent Hydrogen Peroxide Biosensor
Publikováno v:
Biophysical Journal. 109:2148-2158
Fluorescent, genetically encoded sensors of hydrogen peroxide have enabled visualization of perturbations to the intracellular level of this signaling molecule with subcellular and temporal resolution. Ratiometric sensors hold the additional promise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0fdd61f73cfc74fd40158abcb52dcb5
https://doi.org/10.1016/j.bpj.2015.08.053
https://doi.org/10.1016/j.bpj.2015.08.053
Autor:
Hadley D. Sikes, Beijing K. Huang
Publikováno v:
Redox Biology, Vol 2, Iss C, Pp 955-962 (2014)
Redox Biology
Elsevier Open Access
Redox Biology
Elsevier Open Access
Molecular level, mechanistic understanding of the roles of reactive oxygen species (ROS) in a variety of pathological conditions is hindered by the difficulties associated with determining the concentration of various ROS species. Here, we present an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::721b38c007f2a34bff2af1ae7cbde1b1
https://doi.org/10.1016/j.redox.2014.08.001
https://doi.org/10.1016/j.redox.2014.08.001
Publikováno v:
Cell Adhesion & Migration. 2:110-116
Epithelial cell scatter is a well-known in vitro model for the study of epithelial-mesenchymal transition (EMT). Scatter recapitulates many of the events that occur during EMT, including the dissociation of multicellular structures and increased cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de58fb2ce675b1ad6cff1b60e2ab5a31
https://doi.org/10.4161/cam.2.2.6218
https://doi.org/10.4161/cam.2.2.6218
Autor:
Tharathorn Rimchala, Nicholas A. Graham, Beijing K. Huang, Anand R. Asthagiri, Melissa D. Pope
Publikováno v:
SLAS Discovery. 12:683-693
Cell-cell adhesions are a hallmark of epithelial tissues, and the disruption of these contacts plays a critical role in both the early and late stages of oncogenesis. The interaction between the transmembrane protein E-cadherin and the intracellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a131b18427626542879609b0665136c3
https://doi.org/10.1177/1087057107301941
https://doi.org/10.1177/1087057107301941
Publikováno v:
Prof. Sikes Johnson
Genetically encoded, fluorescent biosensors have been developed to probe the activities of various signaling molecules inside cells ranging from changes in intracellular ion concentrations to dynamics of lipid second messengers. HyPer is a member of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d109b15875b3d771140bc6255e93f0
https://orcid.org/0000-0002-7096-138X
https://orcid.org/0000-0002-7096-138X
