Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Beihua Dong"'
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT The 2′,5′-oligoadenylate (2-5A)-dependent endoribonuclease, RNase L, is a principal mediator of the interferon (IFN) antiviral response. Therefore, the regulation of cellular levels of 2-5A is a key point of control in antiviral innate i
Externí odkaz:
https://doaj.org/article/817fafeb64f249a9b658828a1f2de837
Publikováno v:
mBio, Vol 10, Iss 6 (2019)
ABSTRACT Bats are reservoirs for many RNA viruses that are highly pathogenic in humans yet relatively apathogenic in the natural host. It has been suggested that differences in innate immunity are responsible. The antiviral OAS-RNase L pathway is wel
Externí odkaz:
https://doaj.org/article/2abfddbc4d7a4d08a4995b7c0658a0d9
Autor:
Yize Li, Shuvojit Banerjee, Stephen A Goldstein, Beihua Dong, Christina Gaughan, Sneha Rath, Jesse Donovan, Alexei Korennykh, Robert H Silverman, Susan R Weiss
Publikováno v:
eLife, Vol 6 (2017)
ADAR1 isoforms are adenosine deaminases that edit and destabilize double-stranded RNA reducing its immunostimulatory activities. Mutation of ADAR1 leads to a severe neurodevelopmental and inflammatory disease of children, Aicardi-Goutiéres syndrome.
Externí odkaz:
https://doaj.org/article/10892b8d0012417b8d9719dca9a847cd
Autor:
Elona Gusho, Rong Zhang, Babal K. Jha, Joshua M. Thornbrough, Beihua Dong, Christina Gaughan, Ruth Elliott, Susan R. Weiss, Robert H. Silverman
Publikováno v:
mBio, Vol 5, Iss 4 (2014)
ABSTRACT Viral 2′,5′-phosphodiesterases (2′,5′-PDEs) help disparate RNA viruses evade the antiviral activity of interferon (IFN) by degrading 2′,5′-oligoadenylate (2-5A) activators of RNase L. A kinase anchoring proteins (AKAPs) bind the
Externí odkaz:
https://doaj.org/article/4bf6b0d5e0814a6e8a8efd40cf4fe9f0
Autor:
Sanggu Kim, Alice Rusmevichientong, Beihua Dong, Roland Remenyi, Robert H Silverman, Samson A Chow
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10255 (2010)
Xenotropic murine leukemia virus (MLV)-related virus (XMRV) is a new human retrovirus associated with prostate cancer and chronic fatigue syndrome. The causal relationship of XMRV infection to human disease and the mechanism of pathogenicity have not
Externí odkaz:
https://doaj.org/article/17a9cc5716c9410aa2cd342d41c71f0d
Publikováno v:
PLoS ONE, Vol 3, Iss 9, p e3144 (2008)
Murine Leukemia Virus (MLV) is a rodent gammaretrovirus that serves as the backbone for common gene delivery tools designed for experimental and therapeutic applications. Recently, an infectious gammaretrovirus designated XMRV has been identified in
Externí odkaz:
https://doaj.org/article/ede5b5cb44e344e6b7424e5742204029
Autor:
Danyel Lee, Jérémie Le Pen, Ahmad Yatim, Beihua Dong, Yann Aquino, Masato Ogishi, Robert Silverman, Shen-Ying Zhang, Jean-Laurent Casanova
Publikováno v:
Clinical Immunology. 250:109358
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ba95449b18a296707ea3b9396a4a7f5
https://doi.org/10.1016/j.clim.2023.109358
https://doi.org/10.1016/j.clim.2023.109358
Autor:
Hao Huang, Beihua Dong, Frank Sicheri, Yize Li, Robert H. Silverman, Jinle Tang, Christina Gaughan, Daniel Mao, Shuvojit Banerjee, Nicolas Tavernier, Gerald D. Gish, Manisha Talukdar, Salima Daou, Susan R. Weiss, Babal K. Jha, Abiodun A. Ogunjimi, Nicole M. Duffy
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The OAS–RNase L system is an innate immunity pathway activated by viral infection. Viral dsRNA stimulates OAS enzymes to produce short 2′,5′-oligoadenylates (2-5A) that activate RNase L, resulting in cleavage of single-stranded (ss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6862d04f43e5ff97c3a16c0c547a9afe
https://doi.org/10.1073/pnas.2006883117
https://doi.org/10.1073/pnas.2006883117
Publikováno v:
mBio
mBio, Vol 12, Iss 4 (2021)
mBio, Vol 12, Iss 4 (2021)
The 2′,5′-oligoadenylate (2-5A)-dependent endoribonuclease, RNase L, is a principal mediator of the interferon (IFN) antiviral response. Therefore, the regulation of cellular levels of 2-5A is a key point of control in antiviral innate immunity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfe5a0f998557ded9151642f39ed5065
http://europepmc.org/articles/PMC8406329
http://europepmc.org/articles/PMC8406329
Autor:
Susan R. Weiss, Jillian N. Whelan, Hanako M. Reyes, Robert H. Silverman, Beihua Dong, Erick R. Perez, David M. Renner, Yize Li, Nicholas A. Parenti, Joshua Hatterschide
Publikováno v:
Proc Natl Acad Sci U S A
Infection with the flavivirus Zika virus (ZIKV) can result in tissue tropism, disease outcome, and route of transmission distinct from those of other flaviviruses; therefore, we aimed to identify host machinery that exclusively promotes the ZIKV repl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8ca6463210b85a72cae7cf6ca4c3ebc
https://pubmed.ncbi.nlm.nih.gov/34031250
https://pubmed.ncbi.nlm.nih.gov/34031250