Výsledky vyhledávání - "Bei-Er Jiang"

Design, synthesis, and biological evaluation of indole-based hydroxamic acid derivatives as histone deacetylase inhibitors

Autor: Yu Wen, Xiufeng Pang, Jiaxin Hu, Mingyao Liu, Bei-Er Jiang, Zhang Hankun, Hao Liu, Li-Fang Yu, Zhi-Tao Liu

Publikováno v: European journal of medicinal chemistry. 227

The equilibrium between histone acetylation and deacetylation plays an important role in cancer initiation and progression. The histone deacetylases (HDACs) are a class of key regulators of gene expression that enzymatically remove an acetyl moiety f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10b31903da5284042956dadf45c7c421
https://pubmed.ncbi.nlm.nih.gov/34656899

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From a Designer Drug to the Discovery of Selective Cannabinoid Type 2 Receptor Agonists with Favorable Pharmacokinetic Profiles for the Treatment of Systemic Sclerosis

Autor: Chunyang Yi, Qiansen Zhang, Liang Qiuwen, Mingyao Liu, Chen Si, Jiang Xingwu, Qiu Ziliang, Bei-Er Jiang, Xiaolei Chai, Yang Junjie, Weiqiang Lu, Li-Fang Yu, Xiang-Bai Sun, Zhang Hankun

Publikováno v: Journal of medicinal chemistry. 64(1)

Synthetic cannabinoids, as exemplified by SDB-001 (1), bind to both CB1 and CB2 receptors and exert cannabimimetic effects similar to (-)-trans-Δ9-tetrahydrocannabinol, the main psychoactive component present in the cannabis plant. As CB1 receptor l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9a5df5e6fbf3480e26e11371adc116f
https://pubmed.ncbi.nlm.nih.gov/33382613

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Design and optimization of novel hydroxamate-based histone deacetylase inhibitors of Bis-substituted aromatic amides bearing potent activities against tumor growth and metastasis

Autor: Qiang Li, Feifei Yang, Bei-Er Jiang, Jingjie Li, Mingyao Liu, Yang Yang, Xiufeng Pang, Liwen Qin, Yihua Chen, Zhengfang Yi, Ning Liu, Haigang Wu, Xin Wang, Tao Zhang, Ang Chen

Publikováno v: Journal of medicinal chemistry. 57(22)

Histone deacetylases (HDACs) are one of the most promising drug targets for cancer therapy, and since more than 90% of all cancer-related deaths are associated with tumor metastasis, developing strategies to inhibit tumor metastasis while retaining a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b68913371511918d68b5ba86edfb0d6
https://pubmed.ncbi.nlm.nih.gov/25360834

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