Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Behzad Moghadaszadeh"'
Autor:
Qifei Li, Jasmine Lin, Shiyu Luo, Klaus Schmitz‐Abe, Rohan Agrawal, Melissa Meng, Behzad Moghadaszadeh, Alan H. Beggs, Xiaoli Liu, Mark A. Perrella, Pankaj B. Agrawal
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 3, Pp 1003-1015 (2024)
Abstract Background Autosomal‐recessive mutations in SPEG (striated muscle preferentially expressed protein kinase) have been linked to centronuclear myopathy with or without dilated cardiomyopathy (CNM5). Loss of SPEG is associated with defective
Externí odkaz:
https://doaj.org/article/4a401a4397804f1bafdbce30c8191ed7
Autor:
Emma Rybalka, Stephanie Kourakis, Charles A. Bonsett, Behzad Moghadaszadeh, Alan H. Beggs, Cara A. Timpani
Publikováno v:
Pharmaceuticals, Vol 16, Iss 6, p 822 (2023)
Adenylosuccinic acid (ASA) is an orphan drug that was once investigated for clinical application in Duchenne muscular dystrophy (DMD). Endogenous ASA participates in purine recycling and energy homeostasis but might also be crucial for averting infla
Externí odkaz:
https://doaj.org/article/3bbab21ec2a1486fad4722e7e4297f21
Autor:
Qifei Li, Jasmine Lin, Shiyu Luo, Klaus Schmitz-Abe, Rohan Agrawal, Melissa Meng, Behzad Moghadaszadeh, Alan H. Beggs, Xiaoli Liu, Mark A. Perrella, Pankaj B. Agrawal
Publikováno v:
bioRxiv
Autosomal-recessive mutations inSPEG(striated muscle preferentially expressed protein kinase) have been linked to centronuclear myopathy. Loss of SPEG is associated with defective triad formation, abnormal excitation-contraction coupling, and calcium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::738fb4f8b4cc72c35bc0a09c91dc648a
https://doi.org/10.1101/2023.04.24.538136
https://doi.org/10.1101/2023.04.24.538136
Autor:
Guo-Cheng Yuan, Yuxuan Guo, Eric M. Small, Qing Ma, Michael A. Trembley, Alan H. Beggs, Behzad Moghadaszadeh, Emily C Troiano, Blake D. Jardin, Yangpo Cao, Isha Sethi, Neil Mazumdar, William T. Pu
Publikováno v:
Proc Natl Acad Sci U S A
The paucity of knowledge about cardiomyocyte maturation is a major bottleneck in cardiac regenerative medicine. In development, cardiomyocyte maturation is characterized by orchestrated structural, transcriptional, and functional specializations that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a68716eed2520b43d1bba0c2aecf3c6
https://pubmed.ncbi.nlm.nih.gov/33361330
https://pubmed.ncbi.nlm.nih.gov/33361330
Autor:
Jeffrey J. Widrick, Alexandra C. Stanton, Behzad Moghadaszadeh, Amy J. Wagers, Naftali Horwitz, Emily C Troiano, Bryan L Peacker, Mohammadsharif Tabebordbar, Emily M King, Krystynne A Leacock, Pardis C. Sabeti, Simon Ye, Sahar Tavakoli, Kim A. Lagerborg, Kathleen A. Messemer, Alan H. Beggs, Liana Tellez, Allison Krunnfusz
Publikováno v:
Cell. 184(19)
Replacing or editing disease-causing mutations holds great promise for treating many human diseases. Yet, delivering therapeutic genetic modifiers to specific cells in vivo has been challenging, particularly in large, anatomically distributed tissues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e45d7a4abfeb5420171f7106bf4755
https://pubmed.ncbi.nlm.nih.gov/34732902
https://pubmed.ncbi.nlm.nih.gov/34732902
Sarcomeric and nonmuscle α-actinin isoforms exhibit differential dynamics at skeletal muscle Z-lines
Publikováno v:
Cytoskeleton. 75:213-228
The α-actinin proteins are a highly conserved family of actin crosslinkers that mediate interactions between several cytoskeletal and sarcomeric proteins. Non-sarcomeric α-actinin-1 and α-actinin-4 crosslink actin filaments in the cytoskeleton, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a9be76bf6a70f3bd9efe55cb9a60ea3
https://doi.org/10.1002/cm.21442
https://doi.org/10.1002/cm.21442
Autor:
Blake D. Jardin, Emily C Troiano, Behzad Moghadaszadeh, Yuxuan Guo, Isha Sethi, William T. Pu, Michael A. Trembley, Eric M. Small, Guo-Cheng Yuan, Qing Ma, Alan H. Beggs
Cardiomyocyte maturation is essential for robust heart contraction throughout life. The signaling networks governing cardiomyocyte maturation remain poorly defined. Our prior studies established the transcription factor SRF as a key regulator of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::238b043814854f2a3afbd96a000251dd
https://doi.org/10.1101/824185
https://doi.org/10.1101/824185
Publikováno v:
Circulation Research. 125
Cardiomyocyte (CM) maturation is characterized by transcriptional, morphological and functional specializations that are essential for robust and sustained CM contractions throughout lifetime. The signal networks that govern CM maturation remain poor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bf84ef285e1574ec2cbec9ca97f5d07
https://doi.org/10.1161/res.125.suppl_1.920
https://doi.org/10.1161/res.125.suppl_1.920
Autor:
Alan H. Beggs, Martin K. Childers, Behzad Moghadaszadeh, Steve Boukedes, Robert W. Grange, Caroline A. Owen, Branden E. Rider, Kushagra Gupta, Michael W. Lawlor
Publikováno v:
The FASEB Journal. 27:1585-1599
Mutations in the human SEPN1 gene, encoding selenoprotein N (SepN), cause SEPN1-related myopathy (SEPN1-RM) characterized by muscle weakness, spinal rigidity, and respiratory insufficiency. As with other members of the selenoprotein family, selenopro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90cf5eb86b46172d0316483e6b919b99
https://doi.org/10.1096/fj.12-212688
https://doi.org/10.1096/fj.12-212688
Autor:
Pauliina Kronqvist, Finn Cilius Nielsen, Kay E. Davies, Michaela Zaik, Henrik Daa Schrøder, Eva Engvall, Rehannah Borup, Ulla M. Wewer, Thomas Voit, Nobuko Kawaguchi, Behzad Moghadaszadeh, Ling T. Guo, Reidar Albrechtsen
Publikováno v:
Moghadaszadeh, B, Albrechtsen, R, Guo, L T, Zaik, M, Kawaguchi, N, Borup, R H, Kronqvist, P, Schrøder, H D, Davies, K E, Voit, T, Nielsen, F C, Engvall, E & Wewer, U M 2003, ' Compensation for dystrophin-deficiency : ADAM12 overexpression in skeletal muscle results in increased α7 integrin, utrophin and associated glycoproteins ', Human Molecular Genetics, vol. 12, no. 19, pp. 2467-79 . https://doi.org/10.1093/hmg/ddg264
Udgivelsesdato: 2003-Oct-1 Mouse models for genetic diseases are among the most powerful tools available for developing and testing new treatment strategies. ADAM12 is a disintegrin and metalloprotease, previously demonstrated to significantly allevi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8d6dada31c7846ef493374e37eb53a8
https://ora.ox.ac.uk/objects/uuid:19d87fd3-c7d3-420c-97c5-f384b8ac7d7a
https://ora.ox.ac.uk/objects/uuid:19d87fd3-c7d3-420c-97c5-f384b8ac7d7a