Suspension-Induced Stem Cell Transition: A Non-Transgenic Method to Generate Adult Stem Cells from Mouse and Human Somatic Cells

Autor: Behzad Yeganeh, Azadeh Yeganeh, Kyle Malone, Shawn T. Beug, Robert P. Jankov

Publikováno v: Cells, Vol 12, Iss 20, p 2508 (2023)

Adult stem cells (ASCs) can be cultured with difficulty from most tissues, often requiring chemical or transgenic modification to achieve adequate quantities. We show here that mouse primary fibroblasts, grown in suspension, change from the elongated

Externí odkaz: https://doaj.org/article/f604cad77eec4beabedfb4f84dcd0566

Autophagy in Tumor Immunity and Viral-Based Immunotherapeutic Approaches in Cancer

Autor: Ali Zahedi-Amiri, Kyle Malone, Shawn T. Beug, Tommy Alain, Behzad Yeganeh

Publikováno v: Cells, Vol 10, Iss 10, p 2672 (2021)

Autophagy is a fundamental catabolic process essential for the maintenance of cellular and tissue homeostasis, as well as directly contributing to the control of invading pathogens. Unsurprisingly, this process becomes critical in supporting cellular

Externí odkaz: https://doaj.org/article/999b098f42c74916b8d776825eba77e9

Acellular Lung Scaffolds Direct Differentiation of Endoderm to Functional Airway Epithelial Cells: Requirement of Matrix-Bound HS Proteoglycans

Autor: Sharareh Shojaie, Leonardo Ermini, Cameron Ackerley, Jinxia Wang, Stephanie Chin, Behzad Yeganeh, Mélanie Bilodeau, Manpreet Sambi, Ian Rogers, Janet Rossant, Christine E. Bear, Martin Post

Publikováno v: Stem Cell Reports, Vol 4, Iss 3, Pp 419-430 (2015)

Efficient differentiation of pluripotent cells to proximal and distal lung epithelial cell populations remains a challenging task. The 3D extracellular matrix (ECM) scaffold is a key component that regulates the interaction of secreted factors with c

Externí odkaz: https://doaj.org/article/9e757d323bfa44a8b6f8872fda062af4

Acid Sphingomyelinase Inhibition Attenuates Cell Death in Mechanically Ventilated Newborn Rat Lung

Autor: Leonardo Ermini, Behzad Yeganeh, Joyce S. Lee, Cameron Ackerley, Claudia Bilodeau, Jeroen Tibboel, Andre A. Kroon, Isabella Caniggia, Irene Lok, Martin Post

Publikováno v: American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine, 199(6), 760-772. American Thoracic Society

Premature infants subjected to mechanical ventilation (MV) are prone to lung injury that may result in bronchopulmonary dysplasia. MV causes epithelial cell death and halts alveolar development. The exact mechanism of MV-induced epithelial cell death

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e518e5911041850a97b22288d3ea4e0
https://doi.org/10.1164/rccm.201803-0583oc

Autophagy and the unfolded protein response promote profibrotic effects of TGF-β1 in human lung fibroblasts

Autor: Nicholas J. Kenyon, Ian M.C. Dixon, Afshin Samali, John B. Patterson, Andrew J. Halayko, Javad Alizadeh, Helmut Unruh, Adel Rezaei Moghadam, Amir A. Zeki, Darryl A. Knight, Shahla Shojaei, Martin Post, Saeid Ghavami, Thomas Klonisch, Sean Ott, Behzad Yeganeh

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology

Idiopathic pulmonary fibrosis (IPF) is a lethal fibrotic lung disease in adults with limited treatment options. Autophagy and the unfolded protein response (UPR), fundamental processes induced by cell stress, are dysregulated in lung fibroblasts and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a81ab66577e8d5f35047fc1d271d18
https://doi.org/10.1152/ajplung.00372.2017