Bone marrow mesenchymal stromal cell-derived extracellular matrix displays altered glycosaminoglycan structure and impaired functionality in Myelodysplastic Syndromes

Autor: Kaur Bains, Amanpreet, Behrens Wu, Lena, Rivière, Jennifer, Rother, Sandra, Magno, Valentina, Friedrich, Jens, Werner, Carsten, Bornhäuser, Martin, Götze, Katharina S., Cross, Michael, Platzbecker, Uwe, Wobus, Manja

Myelodysplastic syndromes (MDS) comprise a heterogeneous group of hematologic malignancies characterized by clonal hematopoiesis, one or more cytopenias such as anemia, neutropenia, or thrombocytopenia, abnormal cellular maturation, and a high risk o

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Bone marrow mesenchymal stromal cell-derived extracellular matrix displays altered glycosaminoglycan structure and impaired functionality in Myelodysplastic Syndromes.

Autor: Bains AK; Medical Department I, Haematology and Cell Therapy, University of Leipzig Medical Center, Leipzig, Germany., Behrens Wu L; Department of Medicine I, University Hospital Carl Gustav Carus, Technische Universität, Dresden, Germany., Rivière J; Department of Medicine III, Hematology/Oncology, School of Medicine, Klinikum rechts der Isar, München, Technical University of Munich, Munich, Germany., Rother S; Center for Molecular Signaling Präklinisches Zentrum für Molekulare Signalverarbeitung (PZMS), Saarland University School of Medicine, Homburg, Germany., Magno V; Max Bergmann Center of Biomaterials, Leibniz Institute of Polymer Research Dresden, Technische Universität (TU) Dresden, Dresden, Germany., Friedrichs J; Max Bergmann Center of Biomaterials, Leibniz Institute of Polymer Research Dresden, Technische Universität (TU) Dresden, Dresden, Germany., Werner C; Max Bergmann Center of Biomaterials, Leibniz Institute of Polymer Research Dresden, Technische Universität (TU) Dresden, Dresden, Germany., Bornhäuser M; Department of Medicine I, University Hospital Carl Gustav Carus, Technische Universität, Dresden, Germany., Götze KS; Department of Medicine III, Hematology/Oncology, School of Medicine, Klinikum rechts der Isar, München, Technical University of Munich, Munich, Germany., Cross M; Medical Department I, Haematology and Cell Therapy, University of Leipzig Medical Center, Leipzig, Germany., Platzbecker U; Medical Department I, Haematology and Cell Therapy, University of Leipzig Medical Center, Leipzig, Germany., Wobus M; Department of Medicine I, University Hospital Carl Gustav Carus, Technische Universität, Dresden, Germany.

Publikováno v: Frontiers in oncology [Front Oncol] 2022 Sep 08; Vol. 12, pp. 961473. Date of Electronic Publication: 2022 Sep 08 (Print Publication: 2022).