Hazard characterization of Alternaria toxins to identify data gaps and improve risk assessment for human health.

Autor: Louro H; Department of Human Genetics, National Institute of Health Dr. Ricardo Jorge (INSA) and Centre for Toxicogenomics and Human Health (ToxOmics), NOVA Medical School, Universidade Nova de Lisboa, Av. Padre Cruz, 1649-016, Lisbon, Portugal., Vettorazzi A; MITOX Research Group, Department of Pharmaceutical Sciences, Faculty of Pharmacy and Nutrition, UNAV-University of Navarra, Pamplona, Spain., López de Cerain A; MITOX Research Group, Department of Pharmaceutical Sciences, Faculty of Pharmacy and Nutrition, UNAV-University of Navarra, Pamplona, Spain., Spyropoulou A; Laboratory of Toxicological Control of Pesticides, Scientific Directorate of Pesticides' Control and Phytopharmacy, Benaki Phytopathological Institute, 145 61, Attica, Greece., Solhaug A; Norwegian Veterinary Institute, PO Box 64, 1431, Ås, Norway., Straumfors A; National Institute of Occupational Health, Gydas Vei 8, 0363, Oslo, Norway., Behr AC; Department Food Safety, BfR, German Federal Institute for Risk Assessment, Max-Dohrnstraße 8-10, 10589, Berlin, Germany., Mertens B; Department of Chemical and Physical Health Risks, Sciensano, Brussels, Belgium., Žegura B; Department of Genetic Toxicology and Cancer Biology, National Institute of Biology, Večna Pot 111, 1000, Ljubljana, Slovenia., Fæste CK; Norwegian Veterinary Institute, PO Box 64, 1431, Ås, Norway., Ndiaye D; INRS, Institut National de Recherche et de Sécurité pour la Prévention des accidents du travail et des maladies professionnelles, Rue du Morvan, CS 60027, 54519, Vandœuvre Lès Nancy Cedex, France., Spilioti E; Laboratory of Toxicological Control of Pesticides, Scientific Directorate of Pesticides' Control and Phytopharmacy, Benaki Phytopathological Institute, 145 61, Attica, Greece., Varga E; Department of Food Chemistry and Toxicology, Faculty of Chemistry, University of Vienna, Vienna, Austria.; Food Hygiene and Technology, University of Veterinary Medicine, Vienna, Veterinärplatz 1, 1210, Vienna, Austria., Dubreil E; Toxicology of Contaminants Unit, Fougères Laboratory, French Agency for Food, Environmental and Occupational Health and Safety, 10 B rue Claude Bourgelat, 35306, Fougères, France., Borsos E; Department of Food Chemistry and Toxicology, Faculty of Chemistry, University of Vienna, Vienna, Austria., Crudo F; Department of Food Chemistry and Toxicology, Faculty of Chemistry, University of Vienna, Vienna, Austria., Eriksen GS; Norwegian Veterinary Institute, PO Box 64, 1431, Ås, Norway., Snapkow I; Department of Chemical Toxicology, Norwegian Institute of Public Health, Lovisenberggate 8, 0456, Oslo, Norway., Henri J; Toxicology of Contaminants Unit, Fougères Laboratory, French Agency for Food, Environmental and Occupational Health and Safety, 10 B rue Claude Bourgelat, 35306, Fougères, France., Sanders J; Department of Chemical and Physical Health Risks, Sciensano, Brussels, Belgium., Machera K; Laboratory of Toxicological Control of Pesticides, Scientific Directorate of Pesticides' Control and Phytopharmacy, Benaki Phytopathological Institute, 145 61, Attica, Greece., Gaté L; INRS, Institut National de Recherche et de Sécurité pour la Prévention des accidents du travail et des maladies professionnelles, Rue du Morvan, CS 60027, 54519, Vandœuvre Lès Nancy Cedex, France., Le Hegarat L; Toxicology of Contaminants Unit, Fougères Laboratory, French Agency for Food, Environmental and Occupational Health and Safety, 10 B rue Claude Bourgelat, 35306, Fougères, France., Novak M; Department of Genetic Toxicology and Cancer Biology, National Institute of Biology, Večna Pot 111, 1000, Ljubljana, Slovenia., Smith NM; Department of Chemical Toxicology, Norwegian Institute of Public Health, Lovisenberggate 8, 0456, Oslo, Norway., Krapf S; National Institute of Occupational Health, Gydas Vei 8, 0363, Oslo, Norway., Hager S; Department of Food Chemistry and Toxicology, Faculty of Chemistry, University of Vienna, Vienna, Austria., Fessard V; Toxicology of Contaminants Unit, Fougères Laboratory, French Agency for Food, Environmental and Occupational Health and Safety, 10 B rue Claude Bourgelat, 35306, Fougères, France., Kohl Y; Fraunhofer Institute for Biomedical Engineering IBMT, Joseph-Von-Fraunhofer-Weg 1, 66280, Sulzbach, Germany., Silva MJ; Department of Human Genetics, National Institute of Health Dr. Ricardo Jorge (INSA) and Centre for Toxicogenomics and Human Health (ToxOmics), NOVA Medical School, Universidade Nova de Lisboa, Av. Padre Cruz, 1649-016, Lisbon, Portugal., Dirven H; Department of Chemical Toxicology, Norwegian Institute of Public Health, Lovisenberggate 8, 0456, Oslo, Norway., Dietrich J; Department Safety in the Food Chain, BfR, German Federal Institute for Risk Assessment, Max-Dohrn-Straße 8-10, 10589, Berlin, Germany., Marko D; Department of Food Chemistry and Toxicology, Faculty of Chemistry, University of Vienna, Vienna, Austria. doris.marko@univie.ac.at.

Publikováno v: Archives of toxicology [Arch Toxicol] 2024 Feb; Vol. 98 (2), pp. 425-469. Date of Electronic Publication: 2023 Dec 26.

Impairment of bile acid metabolism by perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) in human HepaRG hepatoma cells.

Autor: Behr AC; Department of Food Safety, German Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, 10589, Berlin, Germany., Kwiatkowski A; Department of Food Safety, German Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, 10589, Berlin, Germany., Ståhlman M; Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Sahlgrenska Academy, Gothenburg University, 413 45, Gothenburg, Sweden., Schmidt FF; Signatope GmbH, 72770, Reutlingen, Germany., Luckert C; Department of Food Safety, German Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, 10589, Berlin, Germany., Braeuning A; Department of Food Safety, German Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, 10589, Berlin, Germany., Buhrke T; Department of Food Safety, German Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, 10589, Berlin, Germany. thorsten.buhrke@bfr.bund.de.

Publikováno v: Archives of toxicology [Arch Toxicol] 2020 May; Vol. 94 (5), pp. 1673-1686. Date of Electronic Publication: 2020 Apr 06.

Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations.

Autor: Albrecht W; Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany. albrecht@ifado.de., Kappenberg F; Department of Statistics, TU Dortmund University, 44227, Dortmund, Germany., Brecklinghaus T; Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany., Stoeber R; Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany., Marchan R; Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany., Zhang M; Simcyp (A Certara Company), Sheffield, UK., Ebbert K; Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany., Kirschner H; Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany., Grinberg M; Department of Statistics, TU Dortmund University, 44227, Dortmund, Germany.; Department of R&D Global Biostatistics, Epidemiology and Medical Writing, Merck KGaA, Darmstadt, Germany., Leist M; In Vitro Toxicology and Biomedicine, Department of Biology, University of Konstanz, Universitätsstr. 10, PO Box M657, 78457, Constance, Germany., Moritz W; InSphero AG, Wagistrasse 27, 8952, Schlieren, Switzerland., Cadenas C; Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany., Ghallab A; Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany.; Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt., Reinders J; Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany., Vartak N; Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany., van Thriel C; Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany., Golka K; Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany., Tolosa L; Experimental Hepatology Unit, Instituto de Investigación Sanitaria La Fe, Valencia, Spain., Castell JV; Experimental Hepatology Unit, Instituto de Investigación Sanitaria La Fe, Valencia, Spain., Damm G; Department of General-, Visceral- and Transplantation Surgery, Charité University Medicine Berlin, 13353, Berlin, Germany.; Department of Hepatobiliary Surgery and Visceral Transplantation, University of Leipzig, Leipzig, Germany., Seehofer D; Department of General-, Visceral- and Transplantation Surgery, Charité University Medicine Berlin, 13353, Berlin, Germany.; Department of Hepatobiliary Surgery and Visceral Transplantation, University of Leipzig, Leipzig, Germany., Lampen A; Department Food Safety, German Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, 10589, Berlin, Germany., Braeuning A; Department Food Safety, German Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, 10589, Berlin, Germany., Buhrke T; Department Food Safety, German Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, 10589, Berlin, Germany., Behr AC; Department Food Safety, German Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, 10589, Berlin, Germany., Oberemm A; Department Food Safety, German Federal Institute for Risk Assessment, Max-Dohrn-Str. 8-10, 10589, Berlin, Germany., Gu X; College of Veterinary Medicine, Yunnan Agricultural University, Kunming, 650201, Yunnan, People's Republic of China., Kittana N; Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, An-Najah National University, PO Box 7, Nablus, Palestine., van de Water B; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Einsteinweg 55, PO Box 9502, 2300 RA, Leiden, The Netherlands., Kreiling R; Clariant Produkte (Deutschland) GmbH, Am Unisyspark 1, 65843, Sulzbach, Germany., Fayyaz S; Clariant Produkte (Deutschland) GmbH, Am Unisyspark 1, 65843, Sulzbach, Germany., van Aerts L; Medicines Evaluation Board: Pharmacology, Toxicology, Pharmacokinetics, Utrecht, The Netherlands., Smedsrød B; Department of Medical Biology, Vascular Biology Research Group, University of Tromsø, NO-9037, Tromsø, Norway., Ellinger-Ziegelbauer H; Investigational Toxicology, Drug Discovery, Pharmaceuticals, Bayer AG, 42096, Wuppertal, Germany., Steger-Hartmann T; Investigational Toxicology, Drug Discovery, Pharmaceuticals, Bayer AG, 42096, Wuppertal, Germany., Gundert-Remy U; Institute for Clinical Pharmacology and Toxicology, Charité, Universitätsmedizin Berlin, Berlin, Germany., Zeigerer A; Institute for Diabetes and Cancer, Helmholtz Center Munich, 85764 Neuherberg, Germany and Joint Heidelberg-IDC Translational Diabetes Program, Inner Medicine 1, Heidelberg University Hospital, Heidelberg, Germany.; German Center for Diabetes Research (DZD), 85764, Neuherberg, Germany., Ullrich A; Primacyt Cell Culture Technology GmbH, Schwerin, Germany., Runge D; Primacyt Cell Culture Technology GmbH, Schwerin, Germany., Lee SML; Biobank Under the Administration of the Human Tissue and Cell Research Foundation, Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, Germany., Schiergens TS; Biobank Under the Administration of the Human Tissue and Cell Research Foundation, Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, Germany., Kuepfer L; Systems Pharmacology, Bayer AG, Leverkusen, Germany., Aguayo-Orozco A; Translational Disease Systems Biology, NNF Center for Protein Research, University of Copenhagen, Copenhagen, Denmark., Sachinidis A; Institute of Neurophysiology and Center for Molecular Medicine Cologne (CMMC), University of Cologne (UKK), Robert-Koch-Str. 39, 50931, Cologne, Germany., Edlund K; Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany., Gardner I; Simcyp (A Certara Company), Sheffield, UK., Rahnenführer J; Department of Statistics, TU Dortmund University, 44227, Dortmund, Germany., Hengstler JG; Leibniz Research Centre for Working Environment and Human Factors at the Technical University of Dortmund (IfADo), Ardeystrasse 67, 44139, Dortmund, Germany. hengstler@ifado.de.

Publikováno v: Archives of toxicology [Arch Toxicol] 2019 Jun; Vol. 93 (6), pp. 1609-1637. Date of Electronic Publication: 2019 Jun 27.

The urinary metabolites of DINCH ^® have an impact on the activities of the human nuclear receptors ERα, ERβ, AR, PPARα and PPARγ.

Autor: Engel A; German Federal Institute for Risk Assessment, Department of Food Safety, Max-Dohrn-Str. 8-10, 10589 Berlin, Germany., Buhrke T; German Federal Institute for Risk Assessment, Department of Food Safety, Max-Dohrn-Str. 8-10, 10589 Berlin, Germany. Electronic address: thorsten.buhrke@bfr.bund.de., Kasper S; German Federal Institute for Risk Assessment, Department of Food Safety, Max-Dohrn-Str. 8-10, 10589 Berlin, Germany., Behr AC; German Federal Institute for Risk Assessment, Department of Food Safety, Max-Dohrn-Str. 8-10, 10589 Berlin, Germany., Braeuning A; German Federal Institute for Risk Assessment, Department of Food Safety, Max-Dohrn-Str. 8-10, 10589 Berlin, Germany., Jessel S; Biochemical Institute for Environmental Carcinogens, Prof. Dr. Gernot Grimmer Foundation, Lurup 4, 22927 Grosshansdorf, Germany., Seidel A; Biochemical Institute for Environmental Carcinogens, Prof. Dr. Gernot Grimmer Foundation, Lurup 4, 22927 Grosshansdorf, Germany., Völkel W; Bavarian Health and Food Safety Authority, Pfarrstr. 3, 80538 Munich, Germany; University of Würzburg, Department of Toxicology, Versbacher Str. 9, 97078 Würzburg, Germany., Lampen A; German Federal Institute for Risk Assessment, Department of Food Safety, Max-Dohrn-Str. 8-10, 10589 Berlin, Germany.

Publikováno v: Toxicology letters [Toxicol Lett] 2018 May 01; Vol. 287, pp. 83-91. Date of Electronic Publication: 2018 Feb 05.