Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Behnam Nabet"'
Autor:
Annabel T Olson, Yuqi Kang, Anushka M Ladha, Songli Zhu, Chuan Bian Lim, Behnam Nabet, Michael Lagunoff, Taranjit S Gujral, Adam P Geballe
Publikováno v:
PLoS Pathogens, Vol 19, Iss 9, p e1011169 (2023)
Kaposi's sarcoma-associated herpesvirus (KSHV) causes several human diseases including Kaposi's sarcoma (KS), a leading cause of cancer in Africa and in patients with AIDS. KS tumor cells harbor KSHV predominantly in a latent form, while typically
Externí odkaz:
https://doaj.org/article/7bdbcc8d08244e078bda190c159e2904
Autor:
Warren Fiskus, Christopher P. Mill, Behnam Nabet, Dimuthu Perera, Christine Birdwell, Taghi Manshouri, Bernardo Lara, Tapan M. Kadia, Courtney DiNardo, Koichi Takahashi, Naval Daver, Prithviraj Bose, Lucia Masarova, Naveen Pemmaraju, Steven Kornblau, Gautam Borthakur, Guillermo Montalban-Bravo, Guillermo Garcia Manero, Sunil Sharma, Matthew Stubbs, Xiaoping Su, Michael R. Green, Cristian Coarfa, Srdan Verstovsek, Joseph D. Khoury, Christopher R. Vakoc, Kapil N. Bhalla
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 5, Pp 1-16 (2021)
Abstract There is an unmet need to overcome nongenetic therapy-resistance to improve outcomes in AML, especially post-myeloproliferative neoplasm (MPN) secondary (s) AML. Studies presented describe effects of genetic knockout, degradation or small mo
Externí odkaz:
https://doaj.org/article/45520ecba0484c299486fcf8bcac108d
Autor:
Behnam Nabet, Fleur M. Ferguson, Bo Kyung A. Seong, Miljan Kuljanin, Alan L. Leggett, Mikaela L. Mohardt, Amanda Robichaud, Amy S. Conway, Dennis L. Buckley, Joseph D. Mancias, James E. Bradner, Kimberly Stegmaier, Nathanael S. Gray
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
The dTAG system is used to rapidly deplete tagged target proteins in vitro and in vivo, but there are context- and protein-specific differences in its effectiveness. Here, the authors develop a second generation dTAG molecule that can degrade previou
Externí odkaz:
https://doaj.org/article/459b2972ed404c94bc46191739350a3c
Autor:
Teresa Ezponda, Daphné Dupéré-Richer, Christine M. Will, Eliza C. Small, Nobish Varghese, Tej Patel, Behnam Nabet, Relja Popovic, Jon Oyer, Marinka Bulic, Yupeng Zheng, Xiaoxiao Huang, Mrinal Y. Shah, Sayantan Maji, Alberto Riva, Manuela Occhionorelli, Giovanni Tonon, Neil Kelleher, Jonathan Keats, Jonathan D. Licht
Publikováno v:
Cell Reports, Vol 21, Iss 3, Pp 628-640 (2017)
Loss or inactivation of the histone H3K27 demethylase UTX occurs in several malignancies, including multiple myeloma (MM). Using an isogenic cell system, we found that loss of UTX leads to deactivation of gene expression ultimately promoting the prol
Externí odkaz:
https://doaj.org/article/c8e4f4dce46b4e28975494365da80fbf
Autor:
Rita Sulahian, Jason J. Kwon, Katherine H. Walsh, Emma Pailler, Timothy L. Bosse, Maneesha Thaker, Diego Almanza, Joshua M. Dempster, Joshua Pan, Federica Piccioni, Nancy Dumont, Alfredo Gonzalez, Jonathan Rennhack, Behnam Nabet, John A. Bachman, Amy Goodale, Yenarae Lee, Mukta Bagul, Rosy Liao, Adrija Navarro, Tina L. Yuan, Raymond W.S. Ng, Srivatsan Raghavan, Nathanael S. Gray, Aviad Tsherniak, Francisca Vazquez, David E. Root, Ari J. Firestone, Jeff Settleman, William C. Hahn, Andrew J. Aguirre
Publikováno v:
Cell Reports, Vol 29, Iss 1, Pp 118-134.e8 (2019)
Summary: The mitogen-activated protein kinase (MAPK) pathway is a critical effector of oncogenic RAS signaling, and MAPK pathway inhibition may be an effective combination treatment strategy. We performed genome-scale loss-of-function CRISPR-Cas9 scr
Externí odkaz:
https://doaj.org/article/9a62a78ea0ee4966a7135dceb3c889af
Autor:
Mei Zeng, Nicholas P Kwiatkowski, Tinghu Zhang, Behnam Nabet, Mousheng Xu, Yanke Liang, Chunshan Quan, Jinhua Wang, Mingfeng Hao, Sangeetha Palakurthi, Shan Zhou, Qing Zeng, Paul T Kirschmeier, Khyati Meghani, Alan L Leggett, Jun Qi, Geoffrey I Shapiro, Joyce F Liu, Ursula A Matulonis, Charles Y Lin, Panagiotis A Konstantinopoulos, Nathanael S Gray
Publikováno v:
eLife, Vol 7 (2018)
High-grade serous ovarian cancer is characterized by extensive copy number alterations, among which the amplification of MYC oncogene occurs in nearly half of tumors. We demonstrate that ovarian cancer cells highly depend on MYC for maintaining their
Externí odkaz:
https://doaj.org/article/28fdc67b84ee4b348cb7df68b272d1b0
Autor:
Behnam Nabet, Pilib Ó Broin, Jaime M. Reyes, Kevin Shieh, Charles Y. Lin, Christine M. Will, Relja Popovic, Teresa Ezponda, James E. Bradner, Aaron A. Golden, Jonathan D. Licht
Publikováno v:
Cell Reports, Vol 12, Iss 8, Pp 1300-1313 (2015)
Unrestrained receptor tyrosine kinase (RTK) signaling and epigenetic deregulation are root causes of tumorigenesis. We establish linkage between these processes by demonstrating that aberrant RTK signaling unleashed by oncogenic HRasG12V or loss of n
Externí odkaz:
https://doaj.org/article/d46a0408c3ce460aa11345d0ea1375f4
Autor:
Hai-Tsang Huang, Hyuk-Soo Seo, Tinghu Zhang, Yubao Wang, Baishan Jiang, Qing Li, Dennis L Buckley, Behnam Nabet, Justin M Roberts, Joshiawa Paulk, Shiva Dastjerdi, Georg E Winter, Hilary McLauchlan, Jennifer Moran, James E Bradner, Michael J Eck, Sirano Dhe-Paganon, Jean J Zhao, Nathanael S Gray
Publikováno v:
eLife, Vol 6 (2017)
Thorough preclinical target validation is essential for the success of drug discovery efforts. In this study, we combined chemical and genetic perturbants, including the development of a novel selective maternal embryonic leucine zipper kinase (MELK)
Externí odkaz:
https://doaj.org/article/422c1de18104465983f6eb7e8f1d7b55
Autor:
Laurie A Heinicke, Behnam Nabet, Shihao Shen, Peng Jiang, Sebastiaan van Zalen, Benjamin Cieply, J Eric Russell, Yi Xing, Russ P Carstens
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78031 (2013)
Alternative pre-mRNA splicing is a prevalent mechanism in mammals that promotes proteomic diversity, including expression of cell-type specific protein isoforms. We characterized a role for RBM38 (RNPC1) in regulation of alternative splicing during l
Externí odkaz:
https://doaj.org/article/b7538b6b750540caad5897bb54f4cd47
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6491 (2009)
The glomerular podocyte is a highly specialized and polarized kidney cell type that contains major processes and foot processes that extend from the cell body. Foot processes from adjacent podocytes form interdigitations with those of adjacent cells,
Externí odkaz:
https://doaj.org/article/ecbcd6a8e5d94a6f91f35c5c2b749419