Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Begum Akman"'
Publikováno v:
eLife, Vol 12 (2023)
Aurora Kinase A (AURKA) is an oncogenic kinase with major roles in mitosis, but also exerts cell cycle- and kinase-independent functions linked to cancer. Therefore, control of its expression, as well as its activity, is crucial. A short and a long 3
Externí odkaz:
https://doaj.org/article/300b30fd52ff48c3b1906e1521e8b7f3
Autor:
Catherine Lindon, Rogier Schepers, Philippe Giron, Jacques De Greve, H Begum Akman, M Angeles Ceregido, Luis C Ramos Paez, Esther La Monaca, Carl De Trez, Mara Esposito, Olivier Coux, Gustavo J. Gutierrez
Publikováno v:
Oncogene
Oncogene, Nature Publishing Group, 2020, 39 (37), pp.6009-6023. ⟨10.1038/s41388-020-01396-8⟩
Oncogene, Nature Publishing Group, 2020, 39 (37), pp.6009-6023. ⟨10.1038/s41388-020-01396-8⟩
Aurora B kinase plays essential roles in mitosis. Its protein levels increase before the onset of mitosis and sharply decrease during mitosis exit. The latter decrease is due to a balance between the actions of the E3 ubiquitin ligase anaphase-promot
Autor:
Ahmed Abdelbaki, Camilla Ascanelli, Cynthia N. Okoye, Begum Akman, Giacomo Janson, Mingwei Min, Chiara Marcozzi, Anja Hagting, Rhys Grant, Maria De Luca, Italia Anna Asteriti, Giulia Guarguaglini, Alessandro Paiardini, Catherine Lindon
Mitotic kinase Aurora A (AURKA) diverges from other kinases in its multiple active conformations that may explain its interphase roles and association with cancer, and the limited efficacy of drugs targeting the kinase pocket. Regulation of AURKA act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81a712b9078b47556ddd991abb74a9b0
https://doi.org/10.1101/2022.01.31.478464
https://doi.org/10.1101/2022.01.31.478464
Autor:
Ahmed, Abdelbaki, Camilla, Ascanelli, Cynthia N, Okoye, H Begum, Akman, Giacomo, Janson, Mingwei, Min, Chiara, Marcozzi, Anja, Hagting, Rhys, Grant, Maria, De Luca, Italia Anna, Asteriti, Giulia, Guarguaglini, Alessandro, Paiardini, Catherine, Lindon
Publikováno v:
Life science alliance. 6(2)
Mitotic kinase Aurora A (AURKA) diverges from other kinases in its multiple active conformations that may explain its interphase roles and the limited efficacy of drugs targeting the kinase pocket. Regulation of AURKA activity by the cell is critical
Autor:
H Begum Akman, Ahmed Abdelbaki, Giulia Guarguaglini, Olivier Gavet, Catherine Lindon, Marion Poteau, Rhys Grant
Publikováno v:
Journal of Cell Science
article-version (VoR) Version of Record
Journal of cell science (Online) (2020).
info:cnr-pdr/source/autori:Ahmed Abdelbaki, H. Begum Akman, Marion Poteau, Rhys Grant, Olivier Gavet, Giulia Guarguaglini, Catherine Lindon/titolo:AURKA destruction is decoupled from its activity at mitotic exit but essential to suppress interphase activity/doi:/rivista:Journal of cell science (Online)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume
article-version (VoR) Version of Record
Journal of cell science (Online) (2020).
info:cnr-pdr/source/autori:Ahmed Abdelbaki, H. Begum Akman, Marion Poteau, Rhys Grant, Olivier Gavet, Giulia Guarguaglini, Catherine Lindon/titolo:AURKA destruction is decoupled from its activity at mitotic exit but essential to suppress interphase activity/doi:/rivista:Journal of cell science (Online)/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume
Activity of AURKA is controlled through multiple mechanisms including phosphorylation, ubiquitin-mediated degradation and allosteric interaction with TPX2. Activity peaks at mitosis, before AURKA is degraded during and after mitotic exit in a process
Autor:
Marion Poteau, Rhys Grant, H Begum Akman, Ahmed Abdelbaki, Giulia Guarguaglini, Catherine Lindon, Olivier Gavet
Activity of AURKA is controlled through multiple mechanisms including phosphorylation, ubiquitin-mediated degradation, and allosteric interaction with TPX2. Activity peaks at mitosis before AURKA is degraded during mitotic exit in a process strictly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9a8f532a44985ebe94e25d239971cf5
https://doi.org/10.1101/850917
https://doi.org/10.1101/850917
Publikováno v:
Atlas of Genetics and Cytogenetics in Oncology and Haematology.
Review on CHFR (checkpoint with fork-head associated and ring finger), with data on DNA, on the protein encoded, and where the gene is implicated.
Autor:
S. Selcuklu, Mark Ta Donoghue, Mustafa Cengiz Yakicier, Hesna Begum Akman, Charles Spillane, Aysegul Sapmaz, Ayse Elif Erson-Bensan, Shiva Akhavantabasi
Publikováno v:
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 36(5)
MicroRNA (miRNA) deregulation is associated with various cancers. Among an expanding list of cancer-related miRNAs, deregulation of miR-125b has been well documented in many cancers including breast. Based on current knowledge, miR-125b is considered
Autor:
Aysegul Sapmaz, Shiva Akhavantabasi, Hesna Begum Akman, Ayse E. Erson, Jennifer A. Keller, Elizabeth M. Petty
USP32, on chromosomal band 17q23.1-17q23.2, is a highly conserved but uncharacterized gene that gave rise during evolution to a well-known hominoid-specific proto-oncogene, USP6. We investigated the expression profile of USP32 in human tissues and ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4e8c98fbc8a0c76c511ab7719bfc09f
https://aperta.ulakbim.gov.tr/record/25725
https://aperta.ulakbim.gov.tr/record/25725
Publikováno v:
Human Molecular Genetics. :ddv391
Alternative polyadenylation (APA) plays a role in gene expression regulation generally by shortening of 3'UTRs (untranslated regions) upon proliferative signals and relieving microRNA-mediated repression. Owing to high proliferative indices of triple