Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Begoña Martin-Castillo"'
Autor:
Elisabet Cuyàs, Stefano Pedarra, Sara Verdura, Miguel Angel Pardo, Roderic Espin Garcia, Eila Serrano-Hervás, Àngela Llop-Hernández, Eduard Teixidor, Joaquim Bosch-Barrera, Eugeni López-Bonet, Begoña Martin-Castillo, Ruth Lupu, Miguel Angel Pujana, Josep Sardanyès, Tomás Alarcón, Javier A. Menendez
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-17 (2024)
Abstract Fatty acid synthase (FASN)-catalyzed endogenous lipogenesis is a hallmark of cancer metabolism. However, whether FASN is an intrinsic mechanism of tumor cell defense against T cell immunity remains unexplored. To test this hypothesis, here w
Externí odkaz:
https://doaj.org/article/cf58d85bd0c34429bd80f33b1267b08a
Autor:
Javier A. Menendez, Elisabet Cuyàs, Jose Antonio Encinar, Travis Vander Steen, Sara Verdura, Àngela Llop‐Hernández, Júlia López, Eila Serrano‐Hervás, Sílvia Osuna, Begoña Martin‐Castillo, Ruth Lupu
Publikováno v:
Molecular Oncology, Vol 18, Iss 3, Pp 479-516 (2024)
The initial excitement generated more than two decades ago by the discovery of drugs targeting fatty acid synthase (FASN)‐catalyzed de novo lipogenesis for cancer therapy was short‐lived. However, the advent of the first clinical‐grade FASN inh
Externí odkaz:
https://doaj.org/article/d3a6d2c3332d4732a381d0b6a5d9a94b
Autor:
Matthias Pietzke, Salvador Fernandez Arroyo, David Sumpton, Gillian M. Mackay, Begoña Martin-Castillo, Jordi Camps, Jorge Joven, Javier A. Menendez, Alexei Vazquez, On behalf of the METTEN study group
Publikováno v:
Cancer & Metabolism, Vol 7, Iss 1, Pp 1-11 (2019)
Abstract Background Serum and urine metabolites have been investigated for their use as cancer biomarkers. The specificity of candidate metabolites can be limited by the impact of other disorders on metabolite levels. In particular, the increasing in
Externí odkaz:
https://doaj.org/article/22428ceb5f4d4fe69c3782cb5800a37f
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
Metabolism can directly drive or indirectly enable an aberrant chromatin state of cancer cells. The physiological and molecular principles of the metabolic link to epigenetics provide a basis for pharmacological modulation with the anti-diabetic bigu
Externí odkaz:
https://doaj.org/article/606f28326ee14f8b9a3c23043e8cc37f
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 5, p 2705 (2022)
Breast cancer is the most prevalent cancer and the leading cause of cancer-related death among women worldwide. Type 2 diabetes–associated metabolic traits such as hyperglycemia, hyperinsulinemia, inflammation, oxidative stress, and obesity are wel
Externí odkaz:
https://doaj.org/article/39c15e61b4c246d598892d8d51d640d3
Autor:
Joaquim Bosch-Barrera, Ariadna Roqué, Eduard Teixidor, Maria Carmen Carmona-Garcia, Aina Arbusà, Joan Brunet, Begoña Martin-Castillo, Elisabet Cuyàs, Sara Verdura, Javier A. Menendez
Publikováno v:
Pharmaceuticals, Vol 15, Iss 1, p 19 (2021)
COVID-19 pathophysiology is caused by a cascade of respiratory and multiorgan failures arising, at least in part, from the SARS-CoV-2-driven dysregulation of the master transcriptional factor STAT3. Pharmacological correction of STAT3 over-stimulatio
Externí odkaz:
https://doaj.org/article/8b7ee1d49b544476a47992a5e8eac169
Publikováno v:
OncoImmunology, Vol 8, Iss 10 (2019)
The development of a single immuno-metabolic adjuvant capable of modulating, in the appropriate direction and intensity, the complex antagonistic and symbiotic interplays between tumor cells, immune cells, and the gut microbiota may appear pharmacolo
Externí odkaz:
https://doaj.org/article/bc8541831dc8455b8c5891d4f5d61214
Autor:
Elisabet Cuyàs, Maria Buxó, Maria José Ferri Iglesias, Sara Verdura, Sonia Pernas, Joan Dorca, Isabel Álvarez, Susana Martínez, Jose Manuel Pérez-Garcia, Norberto Batista-López, César A. Rodríguez-Sánchez, Kepa Amillano, Severina Domínguez, Maria Luque, Idoia Morilla, Agostina Stradella, Gemma Viñas, Javier Cortés, Jorge Joven, Joan Brunet, Eugeni López-Bonet, Margarita Garcia, Samiha Saidani, Xavier Queralt Moles, Begoña Martin-Castillo, Javier A. Menendez
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Background: The minor allele (C) of the single-nucleotide polymorphism (SNP) rs11212617, located near the ataxia telangiectasia mutated (ATM) gene, has been associated with an increased likelihood of treatment success with metformin in type 2 diabete
Externí odkaz:
https://doaj.org/article/d2338fd8195c45919755b3df06f89a20
Autor:
Elisabet Cuyàs, Sara Verdura, Laura Llorach-Parés, Salvador Fernández-Arroyo, Jorge Joven, Begoña Martin-Castillo, Joaquim Bosch-Barrera, Joan Brunet, Alfons Nonell-Canals, Melchor Sanchez-Martinez, Javier A. Menendez
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
Metformin has been proposed to operate as an agonist of SIRT1, a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase that mimics most of the metabolic responses to calorie restriction. Herein, we present an in silico analysis focusing on t
Externí odkaz:
https://doaj.org/article/c7d9e1e1041d4fcb9bae970f349fbf99
Publikováno v:
Aging.
The mitokine MOTS-c is a mitochondrially-encoded "exercise-mimetic peptide" expressed in multiple tissues, particularly skeletal muscles, which can be detected as a circulating hormone in the blood. MOTS-c mechanisms of action (MoA) involve insulin s