Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Begoña Fernández-Pastor"'
Autor:
Alba Vidal-Torres, Begoña Fernández-Pastor, Mónica García, Eva Ayet, Anna Cabot, Javier Burgueño, Xavier Monroy, Bertrand Aubel, Xavier Codony, Luz Romero, Rosalía Pascual, Maria Teresa Serafini, Gregorio Encina, Carmen Almansa, Daniel Zamanillo, Manuel Merlos, José Miguel Vela
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 1, Pp 82-99 (2023)
Opioids are the most effective painkillers, but their benefit-risk balance often hinder their therapeutic use. WLB-73502 is a dual, bispecific compound that binds sigma-1 (S1R) and mu-opioid (MOR) receptors. WLB-73502 is an antagonist at the S1R. It
Externí odkaz:
https://doaj.org/article/5db3e49f2136462cbd27dfe08f2a9b36
Autor:
Mireia Carcolé, Daniel Zamanillo, Manuel Merlos, Begoña Fernández-Pastor, David Cabañero, Rafael Maldonado
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Osteoarthritis is the most common musculoskeletal disease worldwide, often characterized by degradation of the articular cartilage, chronic joint pain and disability. Cognitive dysfunction, anxiety and depression are common comorbidities that impact
Externí odkaz:
https://doaj.org/article/2c37017385bc4983814fd67aacab6c8b
Autor:
Alba Vidal-Torres, Begoña Fernández-Pastor, Alicia Carceller, José Miguel Vela, Manuel Merlos, Daniel Zamanillo
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Sigma-1 receptor (σ1R) antagonism increases the effects of morphine on acute nociceptive pain. S1RA (E-52862) is a selective σ1R antagonist widely used to study the role of σ1Rs. S1RA alone exerted antinociceptive effect in the formalin test in ra
Externí odkaz:
https://doaj.org/article/af8f3ea2dd064a15bcd1bc93923f0a4b
Autor:
Alba Vidal-Torres, Alicia Carceller, Daniel Zamanillo, Manuel Merlos, José Miguel Vela, Begoña Fernández-Pastor
Publikováno v:
Journal of Pharmacological Sciences, Vol 120, Iss 2, Pp 129-132 (2012)
Measurement of neurotransmitters in the spinal dorsal horn in conscious animals remains a technical challenge. Here we applied concentric microdialysis to measure formalin-induced glutamate (Glu) release in the ipsilateral dorsal horn in conscious, f
Externí odkaz:
https://doaj.org/article/6b03118bed9f4990895989b50719999b
Autor:
Rafael Maldonado, Anthony H. Dickenson, Mireia Carcolé, Leonor Gonçalves, Sami Kummer, Begoña Fernández-Pastor, Manuel Merlos, David Cabañero, Daniel Zamanillo
Publikováno v:
Br J Pharmacol
Background and purpose Osteoarthritic pain is a chronic disabling condition lacking effective treatment. Continuous use of opioid drugs during osteoarthritic pain induces tolerance and may result in dose escalation and abuse. Sigma-1 (σ1) receptors,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7f099ec036e4202a246d6b1a4b8a8ea
https://europepmc.org/articles/PMC6811737/
https://europepmc.org/articles/PMC6811737/
Autor:
Manuel Merlos, Daniel Zamanillo, Alicia Carceller, José Miguel Vela, Begoña Fernández-Pastor, Alba Vidal-Torres
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Frontiers in Pharmacology
Frontiers in Pharmacology
Sigma-1 receptor (σ1R) antagonism increases the effects of morphine on acute nociceptive pain. S1RA (E-52862) is a selective σ1R antagonist widely used to study the role of σ1Rs. S1RA alone exerted antinociceptive effect in the formalin test in ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d36e69d40ee1eac1308e63619c4686
https://doi.org/10.3389/fphar.2019.00422
https://doi.org/10.3389/fphar.2019.00422
Autor:
David Cabañero, Mireia Carcolé, Daniel Zamanillo, Rafael Maldonado, Manuel Merlos, Begoña Fernández-Pastor
Publikováno v:
Frontiers in Pharmacology
Recercat. Dipósit de la Recerca de Catalunya
instname
Frontiers in Pharmacology, Vol 10 (2019)
Recercat. Dipósit de la Recerca de Catalunya
instname
Frontiers in Pharmacology, Vol 10 (2019)
Osteoarthritis is the most common musculoskeletal disease worldwide, often characterized by degradation of the articular cartilage, chronic joint pain and disability. Cognitive dysfunction, anxiety and depression are common comorbidities that impact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55fa6a397c8822b78664849623829774
http://hdl.handle.net/10230/42253
http://hdl.handle.net/10230/42253
Autor:
Manuel Merlos, Alicia Carceller, Alba Vidal-Torres, Begoña Fernández-Pastor, José Miguel Vela, Daniel Zamanillo
Publikováno v:
Journal of Neurochemistry. 129:484-494
We have previously shown that the selective sigma-1 receptor (σ1 R) antagonist S1RA (E-52862) inhibits neuropathic pain and activity-induced spinal sensitization in various pre-clinical pain models. In this study we characterized both the behavioral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abe421402b93b42a8aaaa0bd8355fb34
https://doi.org/10.1111/jnc.12648
https://doi.org/10.1111/jnc.12648
Autor:
Manuel Merlos, Francisco R. Nieto, José M. Baeyens, Lucía Romero, Ángeles Montilla-García, Rosa Montes, Begoña Fernández-Pastor, Rafael González-Cano, Cristina Sánchez-Fernández, Antonia Artacho-Cordón, Enrique J. Cobos, José Manuel Entrena
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 348:32-45
We evaluated the effects of σ 1 -receptor inhibition on μ -opioid–induced mechanical antinociception and constipation. σ 1 -Knockout mice exhibited marked mechanical antinociception in response to several μ -opioid analgesics (fentanyl, oxycodo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9daf2febcf2264065406dc98d0baf6b1
https://doi.org/10.1124/jpet.113.208272
https://doi.org/10.1124/jpet.113.208272
Autor:
Maria Rocasalbas, Alba Vidal-Torres, Rafael Maldonado, José Miguel Vela, Helmut Buschmann, José M. Baeyens, S.A. Bura, Xavier Codony, Daniel Zamanillo, Manuel Merlos, Luz Romero, Beatriz de la Puente, Clara Touriño, Begoña Fernández-Pastor
Publikováno v:
European Journal of Pharmacology. 711:63-72
While opioids are potent analgesics widely used in the management of pain, a number of well-known adverse effects limit their use. The sigma-1 receptor is a ligand-regulated molecular chaperone involved in pain processing, including modulation of opi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea3569efd18364bbb1b51eccb07e186e
https://doi.org/10.1016/j.ejphar.2013.04.018
https://doi.org/10.1016/j.ejphar.2013.04.018