RND3 Potentiates Proinflammatory Activation through NOTCH Signaling in Activated Macrophages

Autor: María José Romero de Ávila, Susana López-López, Aarón García-Blázquez, Almudena Ruiz-García, María Julia González-Gómez, María Luisa Nueda, Victoriano Baladrón, Ignacio Pérez-Roger, Enric Poch, Begoña Ballester-Lurbe, José Javier García-Ramírez, Eva M. Monsalve, María José M. Díaz-Guerra

Publikováno v: Journal of Immunology Research, Vol 2024 (2024)

Macrophage activation is a complex process with multiple control elements that ensures an adequate response to the aggressor pathogens and, on the other hand, avoids an excess of inflammatory activity that could cause tissue damage. In this study, we

Externí odkaz: https://doaj.org/article/dd2c93a234c849d8a88d5e6ba21286a8

Rnd3 Expression is Necessary to Maintain Mitochondrial Homeostasis but Dispensable for Autophagy

Autor: Cristina Cueto-Ureña, Enric Mocholí, Josep Escrivá-Fernández, Susana González-Granero, Sabina Sánchez-Hernández, Amalia Solana-Orts, Begoña Ballester-Lurbe, Karim Benabdellah, Rosa M. Guasch, José Manuel García-Verdugo, Francisco Martín, Paul J. Coffer, Ignacio Pérez-Roger, Enric Poch

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Autophagy is a highly conserved process that mediates the targeting and degradation of intracellular components to lysosomes, contributing to the maintenance of cellular homeostasis and to obtaining energy, which ensures viability under stress condit

Externí odkaz: https://doaj.org/article/7de0449f54f5452689bd32359d3d685e

A CRISPR interference strategy for gene expression silencing in multiple myeloma cell lines

Autor: Enric Poch, Josep Escrivá-Fernández, Cristina Cueto-Ureña, Elisa Lledó, Begoña Ballester-Lurbe

Background: Multiple myeloma is the second most common hematologic neoplasm which is characterized by proliferation and infiltration of plasmatic cells in the bone marrow. Currently, MM is considered incurable due to treatment resistance. The CRISPR/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46fca075cda56c597445b2a310732e04
https://doi.org/10.21203/rs.3.rs-1374796/v1

Rnd3 is necessary for the correct oligodendrocyte differentiation and myelination in the central nervous system

Autor: José Manuel García-Verdugo, Juan Antonio Moreno-Bravo, Begoña Ballester-Lurbe, Ignacio Pérez-Roger, M. P. Madrigal, Eduardo Puelles, Olga Gómez, José Terrado, S. Jurado

Publikováno v: CEU Repositorio Institucional
Fundación Universitaria San Pablo CEU (FUSPCEU)
BRAIN STRUCTURE & FUNCTION
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname

Rho small GTPases are proteins with key roles in the development of the central nervous system. Rnd proteins are a subfamily of Rho GTPases, characterized by their constitutive activity. Rnd3/RhoE is a member of this subfamily ubiquitously expressed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd8c7a8bb3723bae6c8d92868ecd4466
https://pubmed.ncbi.nlm.nih.gov/34724108

Neuronal polarization is impaired in mice lacking RhoE expression

Autor: Begoña Ballester-Lurbe, Rosa M. Guasch, José Terrado, Blanca Peris, José Manuel García-Verdugo, Susana González-Granero, Consuelo Guerri, Ignacio Pérez-Roger

Publikováno v: Journal of Neurochemistry. 121:903-914

J. Neurochem. (2012) 121, 903–914. Abstract Proper development of neuronal networks relies on the polarization of the neurons, thus the establishment of two compartments, axons and dendrites, whose formation depends on cytoskeletal rearrangements.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::56f5186e04bd0efa4435cd1285da2773
https://doi.org/10.1111/j.1471-4159.2012.07733.x