Transcriptomic Analysis Reveals JAK2/MPL-Independent Effects of Calreticulin Mutations in a C. elegans Model

Autor: Ana Guijarro-Hernández, Laura Eder-Azanza, Cristina Hurtado, David Navarro-Herrera, Begoña Ezcurra, Francisco Javier Novo, Juan Cabello, José Luis Vizmanos

Publikováno v: Cells, Vol 12, Iss 1, p 186 (2023)

There is growing evidence that Ph-negative myeloproliferative neoplasms (MPNs) are disorders in which multiple molecular mechanisms are significantly disturbed. Since their discovery, CALR driver mutations have been demonstrated to trigger pathogenic

Externí odkaz: https://doaj.org/article/9bf3ae54cf274e2780705163ba562900

Disruption of the Caenorhabditis elegans Integrator complex triggers a non-conventional transcriptional mechanism beyond snRNA genes.

Autor: Eva Gómez-Orte, Beatriz Sáenz-Narciso, Angelina Zheleva, Begoña Ezcurra, María de Toro, Rosario López, Irene Gastaca, Hilde Nilsen, María P Sacristán, Ralf Schnabel, Juan Cabello

Publikováno v: PLoS Genetics, Vol 15, Iss 2, p e1007981 (2019)

Gene expression is generally regulated by recruitment of transcription factors and RNA polymerase II (RNAP II) to specific sequences in the gene promoter region. The Integrator complex mediates processing of small nuclear RNAs (snRNAs) as well as the

Externí odkaz: https://doaj.org/article/941450dc2f3f4dc6809778dd93f115b9

4D Microscopy: Unraveling Caenorhabditis elegans Embryonic Development Using Nomarski Microscopy

Autor: Victor, Escrich, Begoña, Ezcurra, Eva, Gómez-Orte, Cristina, Romero-Aranda, Antonio, Miranda-Vizuete, Juan, Cabello

Publikováno v: Journal of visualized experiments : JoVE. (164)

4D microscopy is an invaluable tool for unraveling the embryonic developmental process in different animals. Over the last decades, Caenorhabditis elegans has emerged as one of the best models for studying development. From an optical point of view,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::68b75e4e9439cba09f9b448ce5eb76bf
https://pubmed.ncbi.nlm.nih.gov/33104066

Effect of the diet type and temperature on theC. eleganstranscriptome

Autor: María de Toro, Begoña Ezcurra, Juan-Félix San-Juan, Eric Cornes, Angelina Zheleva, Eva Gómez-Orte, Adolfo Sánchez-Blanco, Beatriz Sáenz-Narciso, Rosario López, María Íñiguez, Juan Cabello, Begoña Sacristán, Julián Cerón

Publikováno v: RIUR: Repositorio Institucional de la Universidad de La Rioja
Universidad de La Rioja (UR)
RIUR. Repositorio Institucional de la Universidad de La Rioja
instname

The transcriptomes of model organisms have been defined under specific laboratory growth conditions. The standard protocol for Caenorhabditis elegans growth and maintenance is 20°C on an Escherichia coli diet. Temperatures ranging from 15°C to 25°

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a59733b6b9c2199ebb4f408d6c3b51d
https://doi.org/10.18632/oncotarget.23563

Cell-Penetrating Peptides Containing Fluorescent d-Cysteines

Autor: Marta I. Gutiérrez-Jiménez, Jesús H. Busto, Claudio D. Navo, Jesús M. Peregrina, Ismael Compañón, Gonzalo Jiménez-Osés, Francisco Corzana, Eva Gómez-Orte, Alberto Avenoza, Alicia Asín, Juan Cabello, Begoña Ezcurra, María M. Zurbano

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany). 24(31)

A series of fluorescent d-cysteines (Cys) has been synthesized and their optical properties were studied. The key synthetic step is the highly diastereoselective 1,4-conjugate addition of aryl thiols to a chiral bicyclic dehydroalanine recently devel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e59ed7d47463d2144b3d9973a23a5585
https://pubmed.ncbi.nlm.nih.gov/29603441