Phage small proteins play large roles in phage-bacterial interactions.

Autor: Beggs GA; Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA., Bassler BL; Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address: bbassler@princeton.edu.

Publikováno v: Current opinion in microbiology [Curr Opin Microbiol] 2024 Aug; Vol. 80, pp. 102519. Date of Electronic Publication: 2024 Jul 22.

Small protein modules dictate prophage fates during polylysogeny.

Autor: Silpe JE; Department of Molecular Biology, Princeton University, Princeton, NJ, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Duddy OP; Department of Molecular Biology, Princeton University, Princeton, NJ, USA., Johnson GE; Department of Molecular Biology, Princeton University, Princeton, NJ, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Beggs GA; Department of Molecular Biology, Princeton University, Princeton, NJ, USA., Hussain FA; Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Forsberg KJ; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, USA., Bassler BL; Department of Molecular Biology, Princeton University, Princeton, NJ, USA. bbassler@princeton.edu.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. bbassler@princeton.edu.

Publikováno v: Nature [Nature] 2023 Aug; Vol. 620 (7974), pp. 625-633. Date of Electronic Publication: 2023 Jul 26.

Structures of Neisseria gonorrhoeae MtrR-operator complexes reveal molecular mechanisms of DNA recognition and antibiotic resistance-conferring clinical mutations.

Autor: Beggs GA; Department of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA., Ayala JC; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA., Kavanaugh LG; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA., Read TD; Department of Medicine, and the Emory Antibiotic Resistance Center, Emory University School of Medicine, Atlanta, GA 30322, USA.; Emory Antibiotic Resistance Center, Emory University School of Medicine, Atlanta, GA 30322, USA., Hooks GM; Department of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA., Schumacher MA; Department of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA., Shafer WM; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.; Emory Antibiotic Resistance Center, Emory University School of Medicine, Atlanta, GA 30322, USA.; Laboratories of Bacterial Pathogenesis, VA Medical Center, Decatur, GA 30033, USA., Brennan RG; Department of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2021 Apr 19; Vol. 49 (7), pp. 4155-4170.

MarR family proteins are important regulators of clinically relevant antibiotic resistance.

Autor: Beggs GA; Department of Biochemistry, Duke University, Durham, North Carolina., Brennan RG; Department of Biochemistry, Duke University, Durham, North Carolina., Arshad M; Department of Pediatrics, Ann and Robert H. Lurie Children's Hospital, Northwestern University, Chicago, Illinois.

Publikováno v: Protein science : a publication of the Protein Society [Protein Sci] 2020 Mar; Vol. 29 (3), pp. 647-653. Date of Electronic Publication: 2019 Nov 14.

Structural, Biochemical, and In Vivo Characterization of MtrR-Mediated Resistance to Innate Antimicrobials by the Human Pathogen Neisseria gonorrhoeae .

Autor: Beggs GA; Department of Biochemistry, Duke University School of Medicine, Durham, North Carolina, USA., Zalucki YM; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.; Emory Antibiotic Resistance Center, Emory University School of Medicine, Atlanta, Georgia, USA., Brown NG; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas, USA.; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA., Rastegari S; Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Hospital Research Institute, Houston, Texas, USA.; Department of Biochemistry and Molecular Biology, University of Texas, MD Anderson Cancer Center, Houston, Texas, USA.; Department of Pathology and Genomic Medicine, Houston Methodist Hospital System, Houston, Texas, USA., Phillips RK; Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Hospital Research Institute, Houston, Texas, USA.; Department of Pathology and Genomic Medicine, Houston Methodist Hospital System, Houston, Texas, USA., Palzkill T; Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas, USA.; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA., Shafer WM; Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA.; Laboratories of Microbial Pathogenesis, VA Medical Research Service, Veterans Affairs Medical Center, Decatur, Georgia, USA.; Emory Antibiotic Resistance Center, Emory University School of Medicine, Atlanta, Georgia, USA., Kumaraswami M; Center for Molecular and Translational Human Infectious Diseases Research, Houston Methodist Hospital Research Institute, Houston, Texas, USA mkumaraswami@houstonmethodist.org richard.brennan@duke.edu.; Department of Pathology and Genomic Medicine, Houston Methodist Hospital System, Houston, Texas, USA., Brennan RG; Department of Biochemistry, Duke University School of Medicine, Durham, North Carolina, USA mkumaraswami@houstonmethodist.org richard.brennan@duke.edu.

Publikováno v: Journal of bacteriology [J Bacteriol] 2019 Sep 20; Vol. 201 (20). Date of Electronic Publication: 2019 Sep 20 (Print Publication: 2019).