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Pervasive lesion segregation shapes cancer genome evolution

Autor: Aitken, Sarah J., Anderson, Craig J., Connor, Frances, Pich, Oriol, Sundaram, Vasavi, Feig, Christine, Rayner, Tim F., Lukk, Margus, Aitken, Stuart, Luft, Juliet, Kentepozidou, Elissavet, Arnedo-Pac, Claudia, Beentjes, Sjoerd V., Davies, Susan E., Drews, Ruben M., Ewing, Ailith, Kaiser, Vera B., Khamseh, Ava, López-Arribillaga, Erika, Redmond, Aisling M., Santoyo-Lopez, Javier, Sentís, Inés, Talmane, Lana, Yates, Andrew D., Flicek, Paul, López-Bigas, Núria, Odom, Duncan T., Semple, Colin A., Taylor, Martin S.

Publikováno v: Aitken, S J, Anderson, C J, Connor, F, Pich, O, Sundaram, V, Feig, C, Rayner, T F, Lukk, M, Aitken, S, Luft, J, Kentepozidou, E, Arnedo-Pac, C, Beentjes, S V, Davies, S E, Drews, R M, Ewing, A, Kaiser, V B, Khamseh, A, Lopez-Arribillaga, E, Redmond, A M, Santoyo-Lopez, J, Sentís, I, Talmane, L, Yates, A D, Semple, C A, López-Bigas, N, Flicek, P, Odom, D T & Taylor, M S 2020, ' Pervasive lesion segregation shapes cancer genome evolution ', Nature, vol. 583, pp. 265–270 . https://doi.org/10.1038/s41586-020-2435-1
Nature

SummaryCancers arise through the acquisition of oncogenic mutations and grow through clonal expansion1, 2. Here we reveal that most mutagenic DNA lesions are not resolved as mutations within a single cell-cycle. Instead, DNA lesions segregate unrepai

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