Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Beena Jeevan-Raj"'
Autor:
Fengyuan Tang, Ruize Gao, Beena Jeevan-Raj, Christof B. Wyss, Ravi K. R. Kalathur, Salvatore Piscuoglio, Charlotte K. Y. Ng, Sravanth K. Hindupur, Sandro Nuciforo, Eva Dazert, Thomas Bock, Shuang Song, David Buechel, Marco F. Morini, Alexander Hergovich, Patrick Matthias, Dae-Sik Lim, Luigi M. Terracciano, Markus H. Heim, Michael N. Hall, Gerhard Christofori
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
The autophagic and Hippo pathways are both well characterized contributors to cancer. Here, Tang et al show that LATS1, but not LATS2, negatively regulates autophagy by promoting Beclin1 ubiquitination, which restricts lethal autophagy induced by sor
Externí odkaz:
https://doaj.org/article/1bd4d7c4bf134f42b2b569c6511ab4d1
Autor:
Beena Jeevan-Raj, Jasmine Gehrig, Mélanie Charmoy, Vijaykumar Chennupati, Camille Grandclément, Paolo Angelino, Mauro Delorenzi, Werner Held
Publikováno v:
Cell Reports, Vol 20, Iss 3, Pp 613-626 (2017)
The transcription factor Tcf1 is essential for the development of natural killer (NK) cells. However, its precise role has not been clarified. Our combined analysis of Tcf1-deficient and transgenic mice indicated that Tcf1 guides NK cells through thr
Externí odkaz:
https://doaj.org/article/2000cc21572b4249be1366cf761c249f
Publikováno v:
Viruses, Vol 12, Iss 2, p 126 (2020)
Hepatitis B remains one of the major global health problems more than 40 years after the identification of human hepatitis B virus (HBV) as the causative agent. A critical turning point in combating this virus was the development of a preventative va
Externí odkaz:
https://doaj.org/article/43f6874611b64b64af428f1a56b764f9
Autor:
Elisenda Alari-Pahissa, Camille Grandclément, Beena Jeevan-Raj, Georges Leclercq, André Veillette, Werner Held
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153236 (2016)
Natural Killer (NK) cells attack normal hematopoietic cells that do not express inhibitory MHC class I (MHC-I) molecules, but the ligands that activate NK cells remain incompletely defined. Here we show that the expression of the Signaling Lymphocyte
Externí odkaz:
https://doaj.org/article/e54b09359d284748909260399df43453
Transcriptional regulation of murine natural killer cell development, differentiation and maturation
Publikováno v:
Cellular and Molecular Life Sciences. 75:3371-3379
Natural killer (NK) cells are innate cytotoxic effector cells that play important protective roles against certain pathogens as well as against pathogen-infected and transformed host cells. NK cells continuously arise from adult bone marrow-resident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0ee51f8125f29d59022f897acb52046
https://doi.org/10.1007/s00018-018-2865-1
https://doi.org/10.1007/s00018-018-2865-1
Autor:
Jean-Pierre Bourquin, Beat Bornhauser, Beena Jeevan-Raj, Oliver Hantschel, Werner Held, Joerg Huelsken, Maxime Danilo, Margot Thome, Georgi S Angelov, Anja Irmisch, Noemie Luong-Gardiol, Gianni Cazzaniga, Sara Curtet, Mélanie Charmoy, Yuna Huang, Yves Chalandon, Irene Pizzitola, Imran Siddiqui, Mélanie Juilland
Publikováno v:
Cancer cell, vol. 35, no. 4, pp. 649-663.e10
Cancer Cell, Vol. 35, No 4 (2019) pp. 649-663.e10
Cancer Cell, Vol. 35, No 4 (2019) pp. 649-663.e10
The BCR-ABL1 fusion protein is the cause of chronic myeloid leukemia (CML) and of a significant fraction of adult-onset B cell acute lymphoblastic leukemia (B-ALL) cases. Using mouse models and patient-derived samples, we identified an essential role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::869fd824f5343a345898aaeedb6be11c
https://doi.org/10.5167/uzh-177435
https://doi.org/10.5167/uzh-177435
Autor:
Ravi Kiran Reddy Kalathur, Thomas Bock, Patrick Matthias, Salvatore Piscuoglio, Dae-Sik Lim, Fengyuan Tang, Marco Francesco Morini, David Buechel, Gerhard Christofori, Sravanth K. Hindupur, Sandro Nuciforo, Shuang Song, Markus H. Heim, Eva Dazert, Ruize Gao, Charlotte K.Y. Ng, Alexander Hergovich, Luigi Terracciano, Christof B. Wyss, Michael N. Hall, Beena Jeevan-Raj
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Autophagy perturbation represents an emerging therapeutic strategy in cancer. Although LATS1 and LATS2 kinases, core components of the mammalian Hippo pathway, have been shown to exert tumor suppressive activities, here we report a pro-survival role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16428942cad5d2bee22bbcda3714cb36
https://edoc.unibas.ch/73612/
https://edoc.unibas.ch/73612/
Autor:
Vijaykumar Chennupati, Mauro Delorenzi, Beena Jeevan-Raj, Mélanie Charmoy, Jasmine Gehrig, Camille Grandclément, Paolo Angelino, Werner Held
Publikováno v:
Cell reports, vol. 20, no. 3, pp. 613-626
Cell Reports, Vol 20, Iss 3, Pp 613-626 (2017)
Cell Reports, Vol 20, Iss 3, Pp 613-626 (2017)
The transcription factor Tcf1 is essential for the development of natural killer (NK) cells. However, its precise role has not been clarified. Our combined analysis of Tcf1-deficient and transgenic mice indicated that Tcf1 guides NK cells through thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e428342430ee56b6a6522f8e9a3e8ce4
https://pubmed.ncbi.nlm.nih.gov/28723565
https://pubmed.ncbi.nlm.nih.gov/28723565
Autor:
Georgi S Angelov, Maxime Danilo, Caroline Boudousquié, Vijaykumar Chennupati, Beena Jeevan-Raj, Werner Held, Laurène Pousse, Dietmar Zehn
Publikováno v:
Journal of immunology (Baltimore Md. : 1950)
J Immunol.
Journal of Immunology, vol. 193, no. 6, pp. 2784-2791
J Immunol.
Journal of Immunology, vol. 193, no. 6, pp. 2784-2791
Protection against reinfection is mediated by Ag-specific memory CD8 T cells, which display stem cell–like function. Because canonical Wnt (Wingless/Int1) signals critically regulate renewal versus differentiation of adult stem cells, we evaluated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d9ed203597df2589bcf9031653aba2
Autor:
Florence Cammas, Régine Losson, Jing Wang, Frederick W. Alt, Adeline Page, Vincent Heyer, Beena Jeevan-Raj, Isabelle Robert, Bernardo Reina-San-Martin
Publikováno v:
The Journal of Experimental Medicine
A complex of KAP1 and HP1 is needed to tether AID to the H3K9me3-marked donor switch region during CSR.
Immunoglobulin class switch recombination (CSR) is initiated by double-stranded DNA breaks (DSBs) in switch regions triggered by activation-i
Immunoglobulin class switch recombination (CSR) is initiated by double-stranded DNA breaks (DSBs) in switch regions triggered by activation-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4b3b0a35d8107eeee7c76be74abb4ff
https://doi.org/10.1084/jem.20110118
https://doi.org/10.1084/jem.20110118