Identification of compounds with anti-human cytomegalovirus activity that inhibit production of IE2 proteins.

Autor: Beelontally R; Institute of Infection & Immunity, St George's, University of London, London, UK., Wilkie GS; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK., Lau B; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK., Goodmaker CJ; Institute of Infection & Immunity, St George's, University of London, London, UK., Ho CMK; Institute of Infection & Immunity, St George's, University of London, London, UK., Swanson CM; Department of Infectious Diseases, King's College London, London, UK., Deng X; Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, MA, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Wang J; Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, MA, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Gray NS; Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, MA, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Davison AJ; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK., Strang BL; Institute of Infection & Immunity, St George's, University of London, London, UK; Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. Electronic address: bstrang@sgul.ac.uk.

Publikováno v: Antiviral research [Antiviral Res] 2017 Feb; Vol. 138, pp. 61-67. Date of Electronic Publication: 2016 Dec 09.

The role of autophagy in human cytomegalovirus IE2 expression.

Autor: Zhang, Xinyan, Xi, Ting, Zhang, Linlin, Bi, Yidan, Huang, Yuan, Lu, Yuanyuan, Liu, Xinglou, Fang, Feng

Publikováno v: Journal of Medical Virology; Jun2021, Vol. 93 Issue 6, p3795-3803, 9p

Identification of compounds with anti-human cytomegalovirus activity that inhibit production of IE2 proteins

Autor: Charles J. Goodmaker, Andrew J. Davison, Xianming Deng, Jinhua Wang, Catherine M.K. Ho, Blair L. Strang, Rooksarr Beelontally, Chad M. Swanson, Gavin S. Wilkie, Nathanael S. Gray, Betty Lau

Publikováno v: Antiviral Research
Beelontally, R, Wilkie, G S, Lau, B, Goodmaker, C J, Ho, C M K, Swanson, C M, Deng, X, Wang, J, Gray, N S, Davison, A J & Strang, B L 2017, ' Identification of compounds with anti-human cytomegalovirus activity that inhibit production of IE2 proteins ', Antiviral Research, vol. 138, pp. 61-67 . https://doi.org/10.1016/j.antiviral.2016.12.006

Using a high throughput screening methodology we surveyed a collection of largely uncharacterized validated or suspected kinase inhibitors for anti-human cytomegalovirus (HCMV) activity. From this screen we identified three structurally related 5-ami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c465e85e4f5a2bac10df60f0039001
https://eprints.gla.ac.uk/133278/1/133278.pdf