Improved tumor targeting with chemically cross-linked recombinant antibody fragments

Autor: King, DJ, Turner, A, Farnsworth, AP, Adair, JR, Owens, RJ, Pedley, RB, Baldock, D, Proudfoot, KA, Lawson, AD, Beeley, NR

The construction and use of recombinant chimeric and later fully humanized (CDR-grafted) antibodies to tumor-associated antigens has reduced the immune response generated to these antibodies in clinical studies. However, their long circulating half-l

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Helical intravitreal triamcinolone acetonide implant: a 6-month surgical feasibility study in rabbits.

Autor: Mello-Filho PA; Doheny Retina Institute, Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA., Guven D, Beeley NR, de Juan E Jr, Erickson SR

Publikováno v: Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye [Ophthalmic Surg Lasers Imaging] 2009 Mar-Apr; Vol. 40 (2), pp. 160-8.

Development, implantation, in vivo elution, and retrieval of a biocompatible, sustained release subretinal drug delivery system.

Autor: Beeley NR; Doheny Retina Institute, Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine, University of Southern California, 1450 San Pablo Street, Los Angeles, 90033, USA., Stewart JM, Tano R, Lawin LR, Chappa RA, Qiu G, Anderson AB, de Juan E, Varner SE

Publikováno v: Journal of biomedical materials research. Part A [J Biomed Mater Res A] 2006 Mar 15; Vol. 76 (4), pp. 690-8.

Discovery and SAR of new benzazepines as potent and selective 5-HT(2C) receptor agonists for the treatment of obesity.

Autor: Smith BM; Arena Pharmaceuticals Inc., 6166 Nancy Ridge Drive, San Diego, CA 92121-3223, USA. bsmith@arenapharm.com, Smith JM, Tsai JH, Schultz JA, Gilson CA, Estrada SA, Chen RR, Park DM, Prieto EB, Gallardo CS, Sengupta D, Thomsen WJ, Saldana HR, Whelan KT, Menzaghi F, Webb RR, Beeley NR

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2005 Mar 01; Vol. 15 (5), pp. 1467-70.

The chemistry of biological processes. Editorial overview.

Autor: Hill CH, King FD, Beeley NR

Publikováno v: Current opinion in drug discovery & development [Curr Opin Drug Discov Devel] 2000 Sep; Vol. 3 (5), pp. 500-1.