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of 433
pro vyhledávání: '"Beech, DJ"'
Piezo1 forms a mechanically activated calcium-permeable nonselective cation channel that is functionally important in many cell types. Structural data exist for C-terminal regions, but we lack information about N-terminal regions and how the entire c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::e0372684439e0f4bc8589ec8a9914d56
https://eprints.whiterose.ac.uk/170766/12/1-s2.0-S0006349521001363-main.pdf
https://eprints.whiterose.ac.uk/170766/12/1-s2.0-S0006349521001363-main.pdf
Autor:
Baradaran-Heravi, A, Bauer, CC, Pickles, IB, Hosseini-Farahabadi, S, Balgi, AD, Choi, K, Linley, DM, Beech, DJ, Roberge, M, Bon, RS
Publikováno v:
Journal of Biological Chemistry. 298:101546
Nonsense mutations, which occur in ∼11% of patients with genetic disorders, introduce premature termination codons (PTCs) that lead to truncated proteins and promote nonsense-mediated mRNA decay. Aminoglycosides such as G418 permit PTC readthrough,
Autor:
Maqbool, A, Watt, N, Haywood, N, Viswambharan, H, Skromna, A, Makava, N, Visnagri, A, Shawer, HM, Bridge, K, Muminov, SK, Griffin, K, Beech, DJ, Wheatcroft, SB, Porter, KE, Simmons, KJ, Sukumar, P, Shah, AM, Cubbon, RM, Kearney, MT, Yuldasheva, NY
Insulin resistance leads to excessive endothelial cell (EC) superoxide generation and accelerated atherosclerosis. The principal source of superoxide from the insulin-resistant endothelium is the Nox2 isoform of NADPH oxidase. Here we examine the the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::46075043e9cc4f8e95f89247d9a8e50b
Autor:
Evans, EL, Cuthbertson, K, Endesh, N, Rode, B, Blythe, NM, Hyman, AJ, Hall, SJ, Gaunt, HJ, Ludlow, MJ, Foster, R, Beech, DJ
Publikováno v:
British Journal of Pharmacology
Background and Purpose The mechanosensitive Piezo1 channel has important roles in vascular physiology and disease. Yoda1 is a small‐molecule agonist, but the pharmacology of these channels is otherwise limited. Experimental Approach Yoda1 analogues
BACKGROUND AND PURPOSE The diterpene ester tonantzitlonone (TZL) is a natural product which displays cytotoxicity towards certain types of cancer cell such as renal cell carcinoma cells. The effect is similar to that of (‐)‐Englerin A (EA) and so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::31fdac8881280b99120420c6ef5ea0a9
Autor:
Cheung, SY, Henrot, M, Al-Saad, M, Baumann, M, Muller, H, Unger, A, Rubaiy, HN, Mathar, I, Dinkel, K, Nussbaumer, P, Klebl, B, Freichel, M, Rode, B, Trainor, S, Clapcote, SJ, Christmann, M, Waldmann, H, Abbas, SK, Beech, DJ, Vasudev, NS
Publikováno v:
Oncotarget
(-)-Englerin A (EA) is a natural product which has potent cytotoxic effects on renal cell carcinoma cells and other types of cancer cell but not non-cancer cells. Although selectively cytotoxic to cancer cells, adverse reaction in mice and rats has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::840f59868ea17d359f6d15f300d0871f
Identification of an (−)‐englerin A analogue, which antagonizes (−)‐englerin A at TRPC1/4/5 channels
Autor:
Rubaiy, HN, Seitz, T, Hahn, S, Choidas, A, Habenberger, P, Klebl, B, Dinkel, K, Nussbaumer, P, Waldmann, H, Christmann, M, Beech, DJ
BACKGROUND AND PURPOSE: (−)‐Englerin A (EA) is a potent cytotoxic agent against renal carcinoma cells. It achieves its effects by activation of transient receptor potential canonical (TRPC)4/TRPC1 heteromeric channels. It is also an agonist at ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::426bc99144e16391fb962f1fe1dae33f
https://europepmc.org/articles/PMC5811624/
https://europepmc.org/articles/PMC5811624/