Type 1 diabetes risk genes mediate pancreatic beta cell survival in response to proinflammatory cytokines

Autor: Benaglio, Paola, Zhu, Han, Okino, Mei-Lin, Yan, Jian, Elgamal, Ruth, Nariai, Naoki, Beebe, Elisha, Korgaonkar, Katha, Qiu, Yunjiang, Donovan, Margaret K.R., Chiou, Joshua, Wang, Gaowei, Newsome, Jacklyn, Kaur, Jaspreet, Miller, Michael, Preissl, Sebastian, Corban, Sierra, Aylward, Anthony, Taipale, Jussi, Ren, Bing, Frazer, Kelly A., Sander, Maike, Gaulton, Kyle J.

Publikováno v: In Cell Genomics 14 December 2022 2(12)

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Integration of single-cell multiomic measurements across disease states with genetics identifies mechanisms of beta cell dysfunction in type 2 diabetes.

Autor: Wang G; Department of Pediatrics, University of California San Diego, La Jolla CA, USA.; Pediatric Diabetes Research Center, University of California San Diego, La Jolla CA, USA., Chiou J; Department of Pediatrics, University of California San Diego, La Jolla CA, USA.; Pediatric Diabetes Research Center, University of California San Diego, La Jolla CA, USA.; Biomedical Graduate Studies Program, University of California San Diego, La Jolla CA, USA., Zeng C; Department of Pediatrics, University of California San Diego, La Jolla CA, USA.; Pediatric Diabetes Research Center, University of California San Diego, La Jolla CA, USA., Miller M; Center for Epigenomics, University of California San Diego, La Jolla CA, USA., Matta I; Department of Pediatrics, University of California San Diego, La Jolla CA, USA.; Pediatric Diabetes Research Center, University of California San Diego, La Jolla CA, USA., Han JY; Center for Epigenomics, University of California San Diego, La Jolla CA, USA., Kadakia N; Department of Pediatrics, University of California San Diego, La Jolla CA, USA.; Pediatric Diabetes Research Center, University of California San Diego, La Jolla CA, USA., Okino ML; Department of Pediatrics, University of California San Diego, La Jolla CA, USA.; Pediatric Diabetes Research Center, University of California San Diego, La Jolla CA, USA., Beebe E; Department of Pediatrics, University of California San Diego, La Jolla CA, USA.; Pediatric Diabetes Research Center, University of California San Diego, La Jolla CA, USA., Mallick M; Department of Pediatrics, University of California San Diego, La Jolla CA, USA.; Pediatric Diabetes Research Center, University of California San Diego, La Jolla CA, USA., Camunas-Soler J; Department of Bioengineering, Stanford University, Stanford, USA., Dos Santos T; Department of Pharmacology, University of Alberta, Edmonton, AB, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada., Dai XQ; Department of Pharmacology, University of Alberta, Edmonton, AB, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada., Ellis C; Department of Pharmacology, University of Alberta, Edmonton, AB, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada., Hang Y; Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA.; Departments of Medicine and of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA., Kim SK; Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA.; Departments of Medicine and of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.; Stanford Diabetes Research Center, Stanford University School of Medicine, Stanford, CA, USA., MacDonald PE; Department of Pharmacology, University of Alberta, Edmonton, AB, Canada.; Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada., Kandeel FR; Department of Clinical Diabetes, Endocrinology & Metabolism, City of Hope, Duarte, CA, USA., Preissl S; Center for Epigenomics, University of California San Diego, La Jolla CA, USA.; Institute of Experimental and Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Gaulton KJ; Department of Pediatrics, University of California San Diego, La Jolla CA, USA.; Pediatric Diabetes Research Center, University of California San Diego, La Jolla CA, USA.; Institute for Genomic Medicine, University of California San Diego, La Jolla CA, USA., Sander M; Department of Pediatrics, University of California San Diego, La Jolla CA, USA.; Pediatric Diabetes Research Center, University of California San Diego, La Jolla CA, USA.; Institute for Genomic Medicine, University of California San Diego, La Jolla CA, USA.; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla CA, USA.; Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jan 02. Date of Electronic Publication: 2023 Jan 02.