Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Bee-Zen Peng"'
Autor:
Valentyn Petrychenko, Bee-Zen Peng, Ana C. de A. P. Schwarzer, Frank Peske, Marina V. Rodnina, Niels Fischer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Movement of the ribosome along an mRNA requires the universally-conserved translocase (EF-G in bacteria) that couples GTP hydrolysis to directed movement. Here the authors use time-resolved Cryo-EM to visualize the GTPase-powered step on native trans
Externí odkaz:
https://doaj.org/article/a0333f3b21264298a638acfc47643f66
Autor:
Weiwei Han, Bee‐Zen Peng, Chunyan Wang, Guy E Townsend, Natasha A Barry, Frank Peske, Andrew L Goodman, Jun Liu, Marina V Rodnina, Eduardo A Groisman
Publikováno v:
The EMBO Journal. 42
Protein synthesis is crucial for cell growth and survival yet one of the most energy-consuming cellular processes. How, then, do cells sustain protein synthesis under starvation conditions when energy is limited? To accelerate the translocation of mR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07366b844e2899d04be29900ccd2e052
https://doi.org/10.15252/embj.2022112372
https://doi.org/10.15252/embj.2022112372
Autor:
Frank Peske, Valentyn Petrychenko, Niels Fischer, Marina V. Rodnina, Bee-Zen Peng, Ana C. de A. P. Schwarzer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Nature Communications
Nature Communications
GTPases are regulators of cell signaling acting as molecular switches. The translational GTPase EF-G stands out, as it uses GTP hydrolysis to generate force and promote the movement of the ribosome along the mRNA. The key unresolved question is how G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf2cf0597ea7388f6638cabcdcfe617f
https://doi.org/10.1038/s41467-021-26133-x
https://doi.org/10.1038/s41467-021-26133-x
Publikováno v:
Biological Chemistry. 401:131-142
Elongation factor G (EF-G) is a translational GTPase that acts at several stages of protein synthesis. Its canonical function is to catalyze tRNA movement during translation elongation, but it also acts at the last step of translation to promote ribo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72e977567394feca884c9c2e485f8767
https://doi.org/10.1515/hsz-2019-0313
https://doi.org/10.1515/hsz-2019-0313
Autor:
Tamara Senyushkina, Mariia Klimova, Ingo Wohlgemuth, Bee-Zen Peng, Marina V. Rodnina, Natalia Korniy, Frank Peske, Cristina Maracci, Riccardo Belardinelli, Prajwal Karki, Ekaterina Samatova
Publikováno v:
Nucleic Acids Research
During canonical translation, the ribosome moves along an mRNA from the start to the stop codon in exact steps of one codon at a time. The collinearity of the mRNA and the protein sequence is essential for the quality of the cellular proteome. Sponta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf57e9683df2261a163fa7e199a1668
http://europepmc.org/articles/PMC7026636
http://europepmc.org/articles/PMC7026636
Autor:
Rodnina, Marina V., Peske, Frank, Bee-Zen Peng, Belardinelli, Riccardo, Wintermeyer, Wolfgang
Publikováno v:
Biological Chemistry; Jan2020, Vol. 401 Issue 1, p131-142, 12p, 6 Diagrams
Autor:
Neva Caliskan, Natalia Korniy, Helmut Grubmueller, Riccardo Belardinelli, Lars V. Bock, Frank Peske, Bee-Zen Peng, Marina V. Rodnina
Publikováno v:
Biophysical Journal. 118:546a-547a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a781d482181c32eeb8984776572ddbcb
https://doi.org/10.1016/j.bpj.2019.11.2989
https://doi.org/10.1016/j.bpj.2019.11.2989
Autor:
Frank Peske, Lars V. Bock, Riccardo Belardinelli, Marina V. Rodnina, Helmut Grubmüller, Bee-Zen Peng
Publikováno v:
Science Advances
This study shows how elongation factor G helps to maintain the mRNA reading frame during protein synthesis on the ribosome.
During translation, the ribosome moves along the mRNA one codon at a time with the help of elongation factor G (EF-G). Sp
During translation, the ribosome moves along the mRNA one codon at a time with the help of elongation factor G (EF-G). Sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e0e4c1bea1be61750ba596dccdb4a20
https://hdl.handle.net/21.11116/0000-0005-7983-F21.11116/0000-0005-7985-D21.11116/0000-0005-7986-C
https://hdl.handle.net/21.11116/0000-0005-7983-F21.11116/0000-0005-7985-D21.11116/0000-0005-7986-C
Autor:
Bee-Zen Peng, Tamara Senyushkina, Michael Pearson, Mariia Klimova, Marina V. Rodnina, Ekaterina Samatova, Frank Peske
Publikováno v:
Science Advances
Translational translocase pushes hyper-rotated ribosomes to slide along the noncoding mRNA gap at the cost of GTP hydrolysis.
Translational bypassing is a recoding event during which ribosomes slide over a noncoding region of the messenger RNA (
Translational bypassing is a recoding event during which ribosomes slide over a noncoding region of the messenger RNA (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6aab2300dae418ed6dc40a2c52a7a26
http://europepmc.org/articles/PMC6551183
http://europepmc.org/articles/PMC6551183
Autor:
Mudryi, Vitalii, Frister, Jan Ole, Peng, Bee-Zen, Wohlgemuth, Ingo, Peske, Frank, Rodnina, Marina V
Publikováno v:
Nucleic Acids Research; 10/28/2024, Vol. 52 Issue 19, p11870-11883, 14p