Zobrazeno 1 - 10
of 1 209
pro vyhledávání: '"Bedrosian P"'
Autor:
Guevorguian, Philipp, Bedrosian, Menua, Fahradyan, Tigran, Chilingaryan, Gayane, Khachatrian, Hrant, Aghajanyan, Armen
Recent advancements in large language models have opened new possibilities for generative molecular drug design. We present Chemlactica and Chemma, two language models fine-tuned on a novel corpus of 110M molecules with computed properties, totaling
Externí odkaz:
http://arxiv.org/abs/2407.18897
Autor:
Bailey, Vanessa P., Bendek, Eduardo, Monacelli, Brian, Baker, Caleb, Bedrosian, Gasia, Cady, Eric, Douglas, Ewan S., Groff, Tyler, Hildebrandt, Sergi R., Kasdin, N. Jeremy, Krist, John, Macintosh, Bruce, Mennesson, Bertrand, Morrissey, Patrick, Poberezhskiy, Ilya, Subedi, Hari B., Rhodes, Jason, Roberge, Aki, Ygouf, Marie, Zellem, Robert T., Zhao, Feng, Zimmerman, Neil T.
The Nancy Grace Roman Space Telescope Coronagraph Instrument is a critical technology demonstrator for NASA's Habitable Worlds Observatory. With a predicted visible-light flux ratio detection limit of 1E-8 or better, it will be capable of reaching ne
Externí odkaz:
http://arxiv.org/abs/2309.08672
Autor:
Elizabeth C. Poli, Wenli Dong, Simona F. Shaitelman, Nina Tamirisa, Yu Shen, Isabelle Bedrosian
Publikováno v:
npj Breast Cancer, Vol 10, Iss 1, Pp 1-6 (2024)
Abstract Clinical trials of active surveillance (AS) for Ductal Carcinoma in Situ (DCIS) are underway. We sought to understand the historical management of biologically favorable DCIS and to determine the outcomes of patients who did not have immedia
Externí odkaz:
https://doaj.org/article/984057434f5845b0970f87534dd52691
Autor:
Sriram Vaidyanathan, Jenny L. Kerschner, Alekh Paranjapye, Vrishti Sinha, Brian Lin, Tracy A. Bedrosian, Adrian J. Thrasher, Giandomenico Turchiano, Ann Harris, Matthew H. Porteus
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 1, Pp 102134- (2024)
A “universal strategy” replacing the full-length CFTR cDNA may treat >99% of people with cystic fibrosis (pwCF), regardless of their specific mutations. Cas9-based gene editing was used to insert the CFTR cDNA and a truncated CD19 (tCD19) enrichm
Externí odkaz:
https://doaj.org/article/b980cfbabc854f999ab24fb41f1df1a5
Autor:
Tomohisa Toda, Tracy A. Bedrosian, Simon T. Schafer, Michael S. Cuoco, Sara B. Linker, Saeed Ghassemzadeh, Lisa Mitchell, Jack T. Whiteley, Nicole Novaresi, Aidan H. McDonald, Iryna S. Gallina, Hyojung Yoon, Mark E. Hester, Monique Pena, Christina Lim, Emelia Suljic, Abed AlFatah Mansour, Matthieu Boulard, Sarah L. Parylak, Fred H. Gage
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113774- (2024)
Summary: Long interspersed nuclear element-1 (L1 or LINE-1) is a highly abundant mobile genetic element in both humans and mice, comprising almost 20% of each genome. L1s are silenced by several mechanisms, as their uncontrolled expression has the po
Externí odkaz:
https://doaj.org/article/6688623518d44adfa7c2bcdc893f7bd4
Autor:
Zachary P Wallace, Bryan E Bedrosian, Jeffrey R Dunk, David W LaPlante, Brian Woodbridge, Brian W Smith, Jessi L Brown, Todd M Lickfett, Katherine Gura, Dave Bittner, Ross H Crandall, Rob Domenech, Todd E Katzner, Kevin J Kritz, Stephen B Lewis, Michael J Lockhart, Tricia A Miller, Katie Quint, Adam Shreading, Steve J Slater, Dale W Stahlecker
Publikováno v:
PLoS ONE, Vol 19, Iss 1, p e0297345 (2024)
Wildlife conservation strategies focused on one season or population segment may fail to adequately protect populations, especially when a species' habitat preferences vary among seasons, age-classes, geographic regions, or other factors. Conservatio
Externí odkaz:
https://doaj.org/article/6c438dbc1d374fc78ba920ae07541433
Autor:
Bessel A van der Kolk, Julie B Wang, Rachel Yehuda, Leah Bedrosian, Allison R Coker, Charlotte Harrison, Michael Mithoefer, Berra Yazar-Klosinki, Amy Emerson, Rick Doblin
Publikováno v:
PLoS ONE, Vol 19, Iss 1, p e0295926 (2024)
IntroductionThere is a resurgence of interest in the therapeutic potential of psychedelic substances such as 3,4-methylenedioxymethamphetamine (MDMA). Primary findings from our randomized, double-blind, placebo-controlled, multi-site Phase 3 clinical
Externí odkaz:
https://doaj.org/article/af757185a4bb47e1b00ece3c0c4b3854
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