Endogenous adenine is a potential driver of the cardiovascular-kidney-metabolic syndrome.

Autor: Tamayo I; Center for Precision Medicine, University of Texas Health San Antonio., Lee HJ; Center for Precision Medicine, University of Texas Health San Antonio., Aslam MI; Division of Cardiology, University of Texas Health San Antonio., Liu JJ; Clinical Research Unit, Khoo Teck Puat Hospital, Singapore., Ragi N; Center for Precision Medicine, University of Texas Health San Antonio., Karanam V; Division of Cardiology, University of Texas Health San Antonio., Maity S; Center for Precision Medicine, University of Texas Health San Antonio., Saliba A; Center for Precision Medicine, University of Texas Health San Antonio., Treviño E; Center for Precision Medicine, University of Texas Health San Antonio., Zheng H; Clinical Research Unit, Khoo Teck Puat Hospital, Singapore., Lim SC; Clinical Research Unit, Khoo Teck Puat Hospital, Singapore., Lanzer JD; Heidelberg University Hospital, Institute for Computational Biomedicine, Heidelberg, Germany., Bjornstad P; UW Medicine Diabetes Institute, University of Washington., Tuttle K; Department of Medicine, University of Washington, Seattle, WA, USA, Division of Nephrology, Department of Medicine, Kidney Research Institute, University of Washington, Seattle, Washington., Bedi KC Jr; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Margulies KB; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Ramachandran V; Division of Cardiology, University of Texas Health San Antonio.; School of Public Health University of Texas Health San Antonio and University of Texas San Antonio., Abdel-Latif A; Department of Medicine, University of Michigan, Ann Arbor, MI., Saez-Rodriguez J; Heidelberg University Hospital, Institute for Computational Biomedicine, Heidelberg, Germany., Iyengar R; Department of Pharmacological Sciences and Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY., Bopassa JC; Department of Cellular and Integrative Physiology, University of Texas Health San Antonio, San Antonio, Texas., Sharma K; Center for Precision Medicine, University of Texas Health San Antonio.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2024 Aug 20. Date of Electronic Publication: 2024 Aug 20.

Vasohibin inhibition improves myocardial relaxation in a rat model of heart failure with preserved ejection fraction.

Autor: Eaton DM; Department of Medicine and Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Lee BW; Department of Medicine and Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Caporizzo MA; Department of Physiology and Pennsylvania Muscle Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Molecular Physiology and Biophysics, University of Vermont's Larner College of Medicine, Burlington, VT 05405, USA., Iyengar A; Division of Cardiac Surgery, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Chen CY; Department of Physiology and Pennsylvania Muscle Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Uchida K; Department of Physiology and Pennsylvania Muscle Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Marcellin G; MT-act, CRBM, Montpellier 34396, France., Lannay Y; MT-act, CRBM, Montpellier 34396, France., Vite A; Department of Medicine and Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Bedi KC Jr; Department of Medicine and Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Brady CF; Department of Medicine and Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Smolyak JN; Department of Medicine and Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Meldrum D; Division of Cardiac Surgery, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Dominic J; Division of Cardiac Surgery, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Weingarten N; Division of Cardiac Surgery, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Patel M; Division of Cardiac Surgery, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Belec A; Division of Cardiac Surgery, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Hached K; MT-act, CRBM, Montpellier 34396, France., Atluri P; Division of Cardiac Surgery, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Van Der Laan S; MT-act, CRBM, Montpellier 34396, France., Prosser BL; Department of Physiology and Pennsylvania Muscle Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Margulies KB; Department of Medicine and Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2024 Jul 17; Vol. 16 (756), pp. eadm8842. Date of Electronic Publication: 2024 Jul 17.

Integrating Clinical Phenotype With Multiomics Analyses of Human Cardiac Tissue Unveils Divergent Metabolic Remodeling in Genotype-Positive and Genotype-Negative Patients With Hypertrophic Cardiomyopathy.

Autor: Nollet EE; Department of Physiology (E.E.N., M.S., D.W.D.K., J.v.d.V.), Amsterdam UMC, the Netherlands.; Amsterdam Cardiovascular Sciences, Heart Failure and Arrhythmias, the Netherlands (E.E.N., M.S., D.W.D.K., J.v.d.V.)., Schuldt M; Department of Physiology (E.E.N., M.S., D.W.D.K., J.v.d.V.), Amsterdam UMC, the Netherlands.; Amsterdam Cardiovascular Sciences, Heart Failure and Arrhythmias, the Netherlands (E.E.N., M.S., D.W.D.K., J.v.d.V.)., Sequeira V; Department of Translational Science Universitätsklinikum, Deutsches Zentrum für Herzinsuffizienz, Würzburg, Germany (V.S.)., Binek A; Advanced Clinical Biosystems Research Institute (A.B., J.E.V.E.), Cedars-Sinai Medical Center, Los Angeles, CA., Pham TV; Department of Medical Oncology, VUmc Cancer Center Amsterdam, OncoProteomics Laboratory (T.V.P., C.R.J.), Amsterdam UMC, the Netherlands., Schoonvelde SAC; Department of Cardiology, Erasmus MC, Rotterdam, the Netherlands (S.A.C.S., M.M.)., Jansen M; Division of Genetics and Department of Cardiology, UMC Utrecht, the Netherlands (M.J.)., Schomakers BV; Laboratory Genetic Metabolic Diseases (B.V.S., M.v.W., F.M.V., R.H.H.), Amsterdam UMC, the Netherlands.; Core Facility Metabolomics (B.V.S., M.v.W., F.M.V.), Amsterdam UMC, the Netherlands., van Weeghel M; Laboratory Genetic Metabolic Diseases (B.V.S., M.v.W., F.M.V., R.H.H.), Amsterdam UMC, the Netherlands.; Core Facility Metabolomics (B.V.S., M.v.W., F.M.V.), Amsterdam UMC, the Netherlands., Vaz FM; Laboratory Genetic Metabolic Diseases (B.V.S., M.v.W., F.M.V., R.H.H.), Amsterdam UMC, the Netherlands.; Core Facility Metabolomics (B.V.S., M.v.W., F.M.V.), Amsterdam UMC, the Netherlands., Houtkooper RH; Laboratory Genetic Metabolic Diseases (B.V.S., M.v.W., F.M.V., R.H.H.), Amsterdam UMC, the Netherlands.; Emma Center for Personalized Medicine (R.H.H.), Amsterdam UMC, the Netherlands.; Amsterdam Gastroenterology, Endocrinology and Metabolism, the Netherlands (R.H.H.)., Van Eyk JE; Advanced Clinical Biosystems Research Institute (A.B., J.E.V.E.), Cedars-Sinai Medical Center, Los Angeles, CA.; Department of Biomedical Sciences, Smidt Heart Institute (J.E.V.E.), Cedars-Sinai Medical Center, Los Angeles, CA., Jimenez CR; Department of Medical Oncology, VUmc Cancer Center Amsterdam, OncoProteomics Laboratory (T.V.P., C.R.J.), Amsterdam UMC, the Netherlands., Michels M; Department of Cardiology, Erasmus MC, Rotterdam, the Netherlands (S.A.C.S., M.M.)., Bedi KC Jr; Cardiovascular Institute, Perelman School of Medicine, Philadelphia, PA (K.C.B., K.B.M.)., Margulies KB; Cardiovascular Institute, Perelman School of Medicine, Philadelphia, PA (K.C.B., K.B.M.)., Dos Remedios CG; Sydney Heart Bank, Discipline of Anatomy, Bosch Institute, University of Sydney, NSW, Australia (C.G.d.R.)., Kuster DWD; Department of Physiology (E.E.N., M.S., D.W.D.K., J.v.d.V.), Amsterdam UMC, the Netherlands.; Amsterdam Cardiovascular Sciences, Heart Failure and Arrhythmias, the Netherlands (E.E.N., M.S., D.W.D.K., J.v.d.V.)., van der Velden J; Department of Physiology (E.E.N., M.S., D.W.D.K., J.v.d.V.), Amsterdam UMC, the Netherlands.; Amsterdam Cardiovascular Sciences, Heart Failure and Arrhythmias, the Netherlands (E.E.N., M.S., D.W.D.K., J.v.d.V.).

Publikováno v: Circulation. Genomic and precision medicine [Circ Genom Precis Med] 2024 Jun; Vol. 17 (3), pp. e004369. Date of Electronic Publication: 2024 Jun 10.

Adult human cardiomyocyte mechanics in osteogenesis imperfecta.

Autor: Lee BW; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States., Caporizzo MA; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States., Chen CY; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States., Bedi KC Jr; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States., Peyster EG; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States., Prosser BL; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States., Margulies KB; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States., Vite A; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States.

Publikováno v: American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2023 Oct 01; Vol. 325 (4), pp. H814-H821. Date of Electronic Publication: 2023 Aug 11.

Single-nucleus RNA sequencing in ischemic cardiomyopathy reveals common transcriptional profile underlying end-stage heart failure.

Autor: Simonson B; Precision Cardiology Laboratory, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Chaffin M; Precision Cardiology Laboratory, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Hill MC; Precision Cardiology Laboratory, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA., Atwa O; Precision Cardiology Laboratory, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Guedira Y; Precision Cardiology Laboratory, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Bhasin H; Precision Cardiology Laboratory, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Hall AW; Precision Cardiology Laboratory, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Gene Regulation Observatory, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Hayat S; Precision Cardiology Laboratory, Bayer US, LLC, Cambridge, MA 02142, USA., Baumgart S; Precision Cardiology Laboratory, Bayer US, LLC, Cambridge, MA 02142, USA., Bedi KC Jr; Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104, USA., Margulies KB; Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104, USA., Klattenhoff CA; Precision Cardiology Laboratory, Bayer US, LLC, Cambridge, MA 02142, USA., Ellinor PT; Precision Cardiology Laboratory, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address: ellinor@mgh.harvard.edu.

Publikováno v: Cell reports [Cell Rep] 2023 Feb 28; Vol. 42 (2), pp. 112086. Date of Electronic Publication: 2023 Feb 14.