DYRK1A interacts with the REST/NRSF-SWI/SNF chromatin remodelling complex to deregulate gene clusters involved in the neuronal phenotypic traits of Down syndrome

Autor: Suonavy Khung-Savatovsky, Sandrine Imbeaud, Karim Benihoud, Jean Marie Moalic, Anne Lise Delezoide, László G. Puskás, Bedel Ngimbous, Pekka Kallunki, Nicolas Ramoz, Gilles Maussion, Ana Cardona, Paul A. Salin, Hervé Delacroix, Philip Gorwood, Michel Simonneau, Yann Loe-Mie, Lawrence Aggerbeck, Aude-Marie Lepagnol-Bestel, Nicolas Agier, Jean-Maurice Delabar, Olivier Delattre, Ágnes Zvara, Frédérique Quignon

Publikováno v: Human Molecular Genetics
Human Molecular Genetics, 2009, 18 (8), pp.1405-1414. ⟨10.1093/hmg/ddp047⟩
Human Molecular Genetics, Oxford University Press (OUP), 2009, 18 (8), pp.1405-1414. ⟨10.1093/hmg/ddp047⟩

International audience; The molecular mechanisms that lead to the cognitive defects characteristic of Down syndrome (DS), the most frequent cause of mental retardation, have remained elusive. Here we use a transgenic DS mouse model (152F7 line) to sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc71ddaafd63dd0e594e2480efdf6df3
https://doi.org/10.1093/hmg/ddp047