Repurposing FDA approved drugs as radiosensitizers for treating hypoxic prostate cancer

Autor: Becky A.S. Bibby, Ronnie Rodrigues Pereira, Ananya Choudhury, Kaye J. Williams, Elisabet More, Darragh G. McArt, Robert G. Bristow, Paul G. O’Reilly, N. Thiruthaneeswaran, Catharine M L West, Lingjian Yang

Publikováno v: Bibby, B A S, Thiruthaneeswaran, N, Yang, L, Pereira, R R, More, E, McArt, D G, O'Reilly, P, Bristow, R G, Williams, K J, Choudhury, A & West, C M L 2021, ' Repurposing FDA approved drugs as radiosensitizers for treating hypoxic prostate cancer ', BMC urology, vol. 21, no. 1, 96 . https://doi.org/10.1186/s12894-021-00856-x
BMC Urology
Bibby, B A S, Thiruthaneeswaran, N, Yang, L, Pereira, R R, More, E, McArt, D G, O'Reilly, P, Bristow, R G, Williams, K J, Choudhury, A & West, C M L 2021, ' Repurposing FDA approved drugs as radiosensitizers for treating hypoxic prostate cancer ', BMC Urology, vol. 21, no. 1, pp. 96 . https://doi.org/10.1186/s12894-021-00856-x
BMC Urology, Vol 21, Iss 1, Pp 1-11 (2021)

Background The presence of hypoxia is a poor prognostic factor in prostate cancer and the hypoxic tumor microenvironment promotes radioresistance. There is potential for drug radiotherapy combinations to improve the therapeutic ratio. We aimed to inv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96352efa42d651655e10ac31beee7b74
https://pure.manchester.ac.uk/ws/files/196449568/s12894_021_00856_x.pdf

OC-0319: Validation of a companion diagnostic biomarker for prospective use in prostate radiotherapy trials

Autor: N. Thiruthaneeswaran, Catharine M L West, Robert G. Bristow, Elisabet More, Ananya Choudhury, Becky A.S. Bibby, Ronnie Rodrigues Pereira

Publikováno v: Radiotherapy and Oncology. 152:S167-S168

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9fe8f56f34f70b40207fe20b7fcdc569
https://doi.org/10.1016/s0167-8140(21)00343-1

Independence of HIF1a and androgen signaling pathways in prostate cancer

Autor: Charles E. Massie, Anne Warren, Franklin Lo, Michelle Osborne, Ian G. Mills, Patrick H. Maxwell, Catharine M L West, H Scott, James Hadfield, Lingjian Yang, Antonio Ramos-Montoya, David E. Neal, Maxine G. B. Tran, Deepa Shukla, Rory Stark, Becky A.S. Bibby, Thomas L. Carroll

Publikováno v: Tran, M G B, Bibby, B A S, Yang, L, Lo, F, Warren, A Y, Shukla, D, Osborne, M, Hadfield, J, Carroll, T, Stark, R, Scott, H, Ramos-Montoya, A, Massie, C, Maxwell, P, West, C M L, Mills, I G & Neal, D E 2020, ' Independence of HIF1a and androgen signaling pathways in prostate cancer ', BMC Cancer, vol. 20, no. 1, pp. 469 . https://doi.org/10.1186/s12885-020-06890-6
BMC Cancer, Vol 20, Iss 1, Pp 1-12 (2020)
BMC Cancer

Funder: Cancer Research UK; doi: http://dx.doi.org/10.13039/501100000289
Background: Therapeutic targeting of the androgen signaling pathway is a mainstay treatment for prostate cancer. Although initially effective, resistance to androgen target

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d8218f2960877a401f969dfe1833bd
https://doi.org/10.1101/848424

Measurement of the acute metabolic response to hypoxia in rat tumours in vivo using magnetic resonance spectroscopy and hyperpolarised pyruvate

Autor: Becky A.S. Bibby, Gillian M. Tozer, Tooba Alizadeh, Stephen Metcalf, Emily G. Wholey, Adriana Bucur, Martyn N.J. Paley, L. J. Williams, Samira Kazan, Joanne E. Bluff, Steven Reynolds

Publikováno v: Radiotherapy and Oncology

Purpose To estimate the rate constant for pyruvate to lactate conversion in tumours in response to a hypoxic challenge, using hyperpolarised 13C1-pyruvate and magnetic resonance spectroscopy. Methods and materials Hypoxic inspired gas was used to man

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce0251da7b70d2c2cbc4828996d981a

Low MiR-187 Expression Promotes Resistance to Chemoradiation Therapy In Vitro and Correlates with Treatment Failure in Patients with Esophageal Adenocarcinoma

Autor: Becky A.S. Bibby, Katherine B. Geiersbach, Stephen G. Maher, Christian N. Paxton, Mary P. Bronner, Laure Marignol, John V. Reynolds, Jacintha O'Sullivan, Niamh Lynam-Lennon, Ann Marie Mongan

Publikováno v: Molecular Medicine, Vol 22, Iss 1, Pp 388-397 (2016)

Esophageal adenocarcinoma (EAC) has a poor prognosis and is increasing in incidence in many Western populations. Neoadjuvant chemoradiation therapy (CRT) followed by surgery is increasingly the standard of care for locally advanced EAC; however, resi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41ca9362da8f54b2d13114af3e41f94f
https://europepmc.org/articles/PMC5072404/