Výsledky vyhledávání - "Becky A Diebold"

Akademický článek

Quinazolin-derived myeloperoxidase inhibitor suppresses influenza A virus-induced reactive oxygen species, pro-inflammatory mediators and improves cell survival.

Autor: Juan A De La Cruz, Thota Ganesh, Becky A Diebold, Weiping Cao, Amelia Hofstetter, Neetu Singh, Amrita Kumar, James McCoy, Priya Ranjan, Susan M E Smith, Suryaprakash Sambhara, J David Lambeth, Shivaprakash Gangappa

Publikováno v: PLoS ONE, Vol 16, Iss 7, p e0254632 (2021)

Superoxide radicals and other reactive oxygen species (ROS) are implicated in influenza A virus-induced inflammation. In this in vitro study, we evaluated the effects of TG6-44, a novel quinazolin-derived myeloperoxidase-specific ROS inhibitor, on in

Externí odkaz: https://doaj.org/article/80b3ccda96934ff1811aa0a4c2c44104

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Akademický článek

NADPH Oxidase 1 Is Associated with Altered Host Survival and T Cell Phenotypes after Influenza A Virus Infection in Mice.

Autor: Amelia R Hofstetter, Juan A De La Cruz, Weiping Cao, Jenish Patel, Jessica A Belser, James McCoy, Justine S Liepkalns, Samuel Amoah, Guangjie Cheng, Priya Ranjan, Becky A Diebold, Wun-Ju Shieh, Sherif Zaki, Jacqueline M Katz, Suryaprakash Sambhara, J David Lambeth, Shivaprakash Gangappa

Publikováno v: PLoS ONE, Vol 11, Iss 2, p e0149864 (2016)

The role of the reactive oxygen species-producing NADPH oxidase family of enzymes in the pathology of influenza A virus infection remains enigmatic. Previous reports implicated NADPH oxidase 2 in influenza A virus-induced inflammation. In contrast, N

Externí odkaz: https://doaj.org/article/614eb1488bae42bd80588d4074854175

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Abstract 1318: Interleukin-1 promotes enhanced functional expression of dual oxidase 2 in human pancreatic cancer cells

Autor: David J. Mallick, Yongzhong Wu, Mariam M. Konaté, Becky A. Diebold, Smitha Antony, Jennifer L. Meitzler, Guojian Jiang, Jiamo Lu, Krishnendu Roy, James H. Doroshow

Publikováno v: Cancer Research. 82:1318-1318

Pancreatic inflammation contributes to increased risk of pancreatic adenocarcinoma (PDAC) development through the release of pro-inflammatory cytokines and generation of reactive oxygen species (ROS). Interleukin-1 (IL-1) is a major upstream pro-infl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a9f49f2124683ae1635474497afd2c3
https://doi.org/10.1158/1538-7445.am2022-1318

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Quinazolin-derived myeloperoxidase inhibitor suppresses influenza A virus-induced reactive oxygen species, pro-inflammatory mediators and improves cell survival

Autor: Weiping Cao, Juan A. De La Cruz, Becky A. Diebold, Neetu Singh, James McCoy, Amelia R. Hofstetter, Priya Ranjan, Thota Ganesh, Suryaprakash Sambhara, Amrita Kumar, Susan M.E. Smith, Shivaprakash Gangappa, J. David Lambeth

Publikováno v: PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0254632 (2021)

Superoxide radicals and other reactive oxygen species (ROS) are implicated in influenza A virus-induced inflammation. In thisin vitrostudy, we evaluated the effects of TG6-44, a novel quinazolin-derived myeloperoxidase-specific ROS inhibitor, on infl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d07c212eda0716c305281a090d3173e
https://doi.org/10.1371/journal.pone.0254632

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Abstract 2915: Synergistic, cytokine mediated stimulation (IL-1α/β + IL-6) of colon cancer cells reveals a novel mechanism of DNA damage facilitated by up-regulation of NOX1 and DUOX2

Autor: Mariam M. Konaté, Smitha Antony, Yongzhong Wu, Annamaria Rapisarda, Petreena Campbell, David J. Mallick, Krishnendu Roy, James H. Doroshow, Becky A. Diebold, Guojian Jiang, Jennifer L. Meitzler, Jiamo Lu, Agnes Juhasz

Publikováno v: Cancer Research. 81:2915-2915

Inflammatory bowel diseases are states of long-term inflammation of the colon resulting from an interplay of environmental factors and dysregulated immune responses. As inflammatory exposure increases over the time frame of active disease, patients w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9724e960088be98db9ade1e24845db86
https://doi.org/10.1158/1538-7445.am2021-2915

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Abstract 1755: E. coli genomic DNA fragments induce cGAS-STING-mediated DUOX2 expression in human pancreatic cancer cells that is associated with H2O2-related DNA damage

Autor: Mallick David, Stephen L. Wang, Smitha Antony, Becky A. Diebold, Mariam M. Konaté, Jiamo Lu, Roy Krishnendu, James H. Doroshow, Jennifer L. Meitzler, Guojian Jiang, Yongzhong Wu

Publikováno v: Cancer Research. 81:1755-1755

There is a growing appreciation that pancreatic cancers harbor higher numbers of bacteria & fungi compared to normal pancreatic tissue in both humans & mice. These microbes have been suggested to contribute to pancreatic carcinogenesis, & impact ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e1c27dfb0a235ab41877274f146bc414
https://doi.org/10.1158/1538-7445.am2021-1755

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Guidelines for the Detection of NADPH Oxidases by Immunoblot and RT-qPCR

Autor: James Jh Doroshow, James Jw McCoy, S Garrett Wilder, David Lambeth, Yerun Zhu, Jennifer Jl Meitzler, Becky Ba Diebold, Xavier De Deken

Publikováno v: Methods in Molecular Biology ISBN: 9781493994236
Methods Mol Biol

The identification of NADPH oxidase (NOX) isoforms in tissues is essential for interpreting experiments and for next step decisions regarding cell lines, animal models, and targeted drug design. Two basic methods, immunoblotting and reverse transcrip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4624c4ce7d11f8cf9651a8c08dc2b5a4
https://doi.org/10.1007/978-1-4939-9424-3_12

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Abstract 3571: Oxidative stress and the ovarian surface epithelium: TGF-β1 stimulation of IOSE cell lines reveals novel upregulation of NADPH oxidase 4, a membrane bound hydrogen peroxide producing enzyme

Autor: Krishnendu Roy, Mariam M. Konaté, Jiamo Lu, Stephen L. Wang, Smitha Antony, Iris Dahan, James H. Doroshow, Guojian Jiang, Agnes Juhasz, Becky A. Diebold, Yongzhong Wu, Jennifer L. Meitzler

Publikováno v: Cancer Research. 80:3571-3571

Normal ovarian surface epithelium (OSE) has been widely studied as the origin of ovarian cancer. Repetitive ovulation has been implicated in cancer initiation based on damage and inflammation incurred to the OSE upon continuous cycles of tear and rep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d5f130b644cc5c220146071b5d25397a
https://doi.org/10.1158/1538-7445.am2020-3571

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Thioxo-dihydroquinazolin-one Compounds as Novel Inhibitors of Myeloperoxidase

Autor: Thota Ganesh, Yerun Zhu, Susan M.E. Smith, Yang Li, J. David Lambeth, Aiming Sun, Becky A. Diebold, James McCoy

Publikováno v: ACS Medicinal Chemistry Letters. 6:1047-1052

Myeloperoxidase (MPO) is a key antimicrobial enzyme, playing a normal role in host defense, but also contributing to inflammatory conditions including neuroinflammatory diseases such as Parkinson's and Alzheimer's. We synthesized and characterized mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fd4b4ae6df0b5da8332297b99e60f43
https://doi.org/10.1021/acsmedchemlett.5b00287

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