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VTA dopamine neurons are hyperexcitable in 3xTg-AD mice due to casein kinase 2-dependent SK channel dysfunction.

Autor: Blankenship HE; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.; Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Carter KA; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA., Pham KD; Genes and Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA., Cassidy NT; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.; Genes and Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA., Markiewicz AN; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA., Thellmann MI; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA., Sharpe AL; Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Freeman WM; Genes and Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.; Oklahoma City Veterans Affairs Medical Center, Oklahoma City, OK, USA., Beckstead MJ; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA. mike-beckstead@omrf.org.; Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. mike-beckstead@omrf.org.; Oklahoma City Veterans Affairs Medical Center, Oklahoma City, OK, USA. mike-beckstead@omrf.org.

Publikováno v: Nature communications [Nat Commun] 2024 Nov 08; Vol. 15 (1), pp. 9673. Date of Electronic Publication: 2024 Nov 08.

Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus.

Autor: Iannitelli AF; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA., Hassenein L; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA., Mulvey B; Department of Psychiatry, Intellectual and Developmental Disabilities Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA.; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, 21205, USA.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA., Blankenship HE; Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104., Liles LC; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA., Sharpe AL; Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, 73117., Pare JF; Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA.; Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Segal A; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA., Sloan SA; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA., Martinowich K; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, 21205, USA.; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, 21205, USA.Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA., McCann KE; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA., Dougherty JD; Department of Psychiatry, Intellectual and Developmental Disabilities Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA., Smith Y; Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA.; Emory National Primate Research Center, Emory University, Atlanta, GA 30329, USA., Beckstead MJ; Aging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104., Weinshenker D; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Aug 04. Date of Electronic Publication: 2024 Aug 04.