Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Beckley K. Davis"'
Autor:
Meng Deng, Jason W. Tam, Lufei Wang, Kaixin Liang, Sirui Li, Lu Zhang, Haitao Guo, Xiaobo Luo, Yang Zhang, Alex Petrucelli, Beckley K. Davis, Brian J. Conti, W. June Brickey, Ching-Chang Ko, Yu L. Lei, Shaocong Sun, Jenny P. -Y. Ting
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
RNA viruses can be detected by immune cell pattern recognition receptors, such as RLRs, resulting in MAVS-TBK1-IRF3 signalling and production of antiviral type 1 interferons. Here the authors show that macrophage TRAF3-interacting protein 3 regulates
Externí odkaz:
https://doaj.org/article/17cacfe2c68542b2a667a747cf1f862c
Autor:
Beckley K Davis, Elisabeth Chapman, Kalida Gawon, Izzy Petrecca, Taylor Baker, Alma Rechnitzer
Publikováno v:
The Journal of Immunology. 208:52.01-52.01
Nucleotide binding domain, leucine rich repeat CARD containing protein 3 (NLRC3) is a member of the NLR gene family. Members of this family have been associated with human inflammatory diseases such as Crohn’s disease and cryopyrin-associated perio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23505f177ec7deb4e253ec9f1aa200a8
https://doi.org/10.4049/jimmunol.208.supp.52.01
https://doi.org/10.4049/jimmunol.208.supp.52.01
Autor:
Julien Pothlichet, Isabelle Meunier, Beckley K Davis, Jenny P-Y Ting, Emil Skamene, Veronika von Messling, Silvia M Vidal
Publikováno v:
PLoS Pathogens, Vol 9, Iss 4, p e1003256 (2013)
Influenza A virus (IAV) triggers a contagious and potentially lethal respiratory disease. A protective IL-1β response is mediated by innate receptors in macrophages and lung epithelial cells. NLRP3 is crucial in macrophages; however, which sensors e
Externí odkaz:
https://doaj.org/article/abc75a8c3f6e416caf8b8c0b6b4f5115
Autor:
Kelly E Roney, Brian P O'Connor, Haitao Wen, Eda K Holl, Elizabeth H Guthrie, Beckley K Davis, Stephen W Jones, Sushmita Jha, Lisa Sharek, Rafael Garcia-Mata, James E Bear, Jenny P-Y Ting
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24795 (2011)
Plexins are cell surface receptors widely studied in the nervous system, where they mediate migration and morphogenesis though the Rho family of small GTPases. More recently, plexins have been implicated in immune processes including cell-cell intera
Externí odkaz:
https://doaj.org/article/3102917f9ddd4ec0bf26a718cc1bd611
Autor:
Beckley K. Davis
Publikováno v:
Mouse Models of Innate Immunity ISBN: 9781493991662
Macrophages are cellular components of the immune system that are essential for responding to pathogens, initiating inflammation and maintaining tissue homeostasis. Isolation, culture, and functional characterization of bone marrow-derived macrophage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ab32803b1ef69dbc748c08e2ee73ac1
https://doi.org/10.1007/978-1-4939-9167-9_3
https://doi.org/10.1007/978-1-4939-9167-9_3
Autor:
Beckley K Davis, Taylor Baker, Alma Rechnitzer, Matthew Hamby, Zachary Troiani, Sarah Stenske, Samuel Davis, Anna Bauer
Publikováno v:
The Journal of Immunology. 204:68.18-68.18
Sensing of cytosolic nucleotides is a critical initial step in the elaboration of type I interferon. One of several upstream receptor cGAS (cyclic-GMP-AMP synthase) binds to cytosolic DNA and generates di-cyclic nucleotides that act as secondary mess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1dac06f2df7e5b954ceff4edf6dd6b03
https://doi.org/10.4049/jimmunol.204.supp.68.18
https://doi.org/10.4049/jimmunol.204.supp.68.18
Autor:
Jenny P.-Y. Ting, A. Alicia Koblansky, Monika Schneider, Beckley K. Davis, Christian Jobin, Dale A. Ramsden, Alex Petrucelli, Yuli Wang, Agnieszka D. Truax, Brianne R. Barker, Marcus Mühlbauer, Nancy L. Allbritton, Justin E. Wilson, Yoshitaka Oyama, W. June Brickey, Arlin B. Rogers, Wei-Chun Chou, Liang Chen
Publikováno v:
Nature Medicine. 21:906-913
The inflammasome activates caspase-1 and the release of interleukin-1β (IL-1β) and IL-18, and several inflammasomes protect against intestinal inflammation and colitis-associated colon cancer (CAC) in animal models. The absent in melanoma 2 (AIM2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3e85e7153ea445cf3609e212a0440ff
https://doi.org/10.1038/nm.3908
https://doi.org/10.1038/nm.3908
Autor:
Meng Deng, Jason W. Tam, Haitao Guo, Lu Zhang, Beckley K Davis, June Brickey, Shaocong Sun, Jenny P Ting
Publikováno v:
The Journal of Immunology. 202:64.12-64.12
Type I interferon (IFN) signaling is important for antiviral and autoimmune response, and it is subjected to tight control, however molecular mechanisms to tune down these pathways is incompletely understood. Upon sensing cytosolic viral RNA, retinoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bb3c970c749af8748773aa808db3eb6
https://doi.org/10.4049/jimmunol.202.supp.64.12
https://doi.org/10.4049/jimmunol.202.supp.64.12
Autor:
Aaron M. Tocker, Sean Cosgriff, Caitlyn N. Fuller, Beckley K. Davis, Catherine M. Powers, Kimberly D. Jacob, Julie K. Tran, Jemma Giannotti, David M. Roberts, Bradford D. Greaves, Heather E. Croy, Ryan A. von Kleeck, Hyun Hyung An, Paige Robinson, Robert J. Yamulla, Andrew V.A. Foley
Most colon cancer cases are initiated by truncating mutations in the tumor suppressor, adenomatous polyposis coli (APC). APC is a critical negative regulator of the Wnt signaling pathway that participates in a multi-protein "destruction complex" to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b49cf501d4ae655985e5ca6cb89da18c
https://europepmc.org/articles/PMC4933447/
https://europepmc.org/articles/PMC4933447/
Autor:
Agnieszka D. Truax, Beckley K. Davis, Jenny P.-Y. Ting, W. June Brickey, Gregory R. Robbins, Lu Zhang
Publikováno v:
Journal of Biological Chemistry. 287:24294-24303
Most of the nucleotide-binding domain, leucine-rich repeat (NLR) proteins regulate responses to microbial and damage-associated products. Class II transactivator (CIITA) has a distinct function as the master regulator of class II major histocompatibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d74887c7061b9c92759322dfb7bf8786
https://doi.org/10.1074/jbc.m112.364604
https://doi.org/10.1074/jbc.m112.364604