Novel selective PDE type 1 inhibitors cause vasodilatation and lower blood pressure in rats.

Autor: Laursen, Morten¹, Beck, Lilliana², Kehler, Jan¹, Christoffersen, Claus Tornby¹, Bundgaard, Christoffer¹, Mogensen, Susie², Mow, Tomas Joachim¹, Pinilla, Estéfano², Knudsen, Jakob Schöllhammer², Hedegaard, Elise Røge², Grunnet, Morten^1,3, Simonsen, Ulf² us@biomed.au.dk, Pinilla, Estéfano⁴ (AUTHOR), Knudsen, Jakob Schöllhammer⁴ (AUTHOR), Hedegaard, Elise Røge⁴ (AUTHOR)

Publikováno v: British Journal of Pharmacology. Aug2017, Vol. 174 Issue 15, p2563-2575. 13p.

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Genetic deficit of KCa 3.1 channels protects against pulmonary circulatory collapse induced by TRPV4 channel activation

Autor: Wandall-Frostholm, Christine, Dalsgaard, Thomas, Bajoriūnas, Vytis, Oliván-Viguera, Aida, Sadda, Veeruanjaneyulu, Beck, Lilliana, Mogensen, Susie, Stankevicius, Edgaras, Simonsen, Ulf, Köhler, Ralf

Publikováno v: Wandall-Frostholm, C, Dalsgaard, T, Bajoriūnas, V, Oliván-Viguera, A, Sadda, V, Beck, L, Mogensen, S, Stankevicius, E, Simonsen, U & Köhler, R 2015, ' Genetic deficit of KCa 3.1 channels protects against pulmonary circulatory collapse induced by TRPV4 channel activation ', British Journal of Pharmacology, pp. 4493–4505 . https://doi.org/10.1111/bph.13234

BACKGROUND AND PURPOSE: The intermediate conductance calcium/calmodulin-regulated K(+) channel KCa 3.1 produces hyperpolarizing K(+) currents that counteract depolarizing currents carried by transient receptor potential (TRP) channels, and provide th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pure_au_____::57e70000ffe931c74210812cfb2f41d5
https://pure.au.dk/portal/da/publications/genetic-deficit-of-kca-31-channels-protects-against-pulmonary-circulatory-collapse-induced-by-trpv4-channel-activation(b7521474-ac31-4ead-9bab-44ad8290e9e4).html

Genetic deficit of KCa 3.1 channels protects against pulmonary circulatory collapse induced by TRPV4 channel activation.

Autor: Wandall ‐ Frostholm, Christine, Dalsgaard, Thomas, Bajoriūnas, Vytis, Oliván ‐ Viguera, Aida, Sadda, Veeruanjaneyulu, Beck, Lilliana, Mogensen, Susie, Stankevicius, Edgaras, Simonsen, Ulf, Köhler, Ralf

Publikováno v: British Journal of Pharmacology; Sep2015, Vol. 172 Issue 18, p4493-4505, 13p, 1 Chart, 8 Graphs

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