Enterocolitis in Patients With Cancer After Antibody Blockade of Cytotoxic T-Lymphocyte–Associated Antigen 4

Autor: Illouz, Frédéric, Wang, Daniel Y, Ye, Fei, Zhao, Shilin, Johnson, Douglas B, Gupta, A., De Felice, K. M., Loftus, E. V., Khanna, S., Beck, Kimberly E., Blansfield, Joseph A., Tran, Khoi Q., Feldman, Andrew L., Hughes, Marybeth S., Royal, Richard E., Kammula, Udai S., Topalian, Suzanne L., Sherry, Richard M., Kleiner, David, Quezado, Martha, Lowy, Israel, Yellin, Michael, Rosenberg, Steven A., Yang, James C., Michot, J. M., Bigenwald, C., Champiat, S., Collins, M., Carbonnel, Franck, Postel-Vinay, S., Berdelou, A., Varga, A., Bahleda, R., Hollebecque, A., Massard, C., Fuerea, A., Ribrag, V., Gazzah, A., Armand, J. P., Amellal, N., Angevin, E., Noel, N., Boutros, C., Mateus, C., Robert, C., Soria, J. C., Marabelle, A., Lambotte, O., Gonzalez, Raul S., Salaria, Safia N., Bohannon, Caitlin D., Huber, Aaron R., Feely, Michael M., Shi, Chanjuan, Marthey, L., Mussini, C., Nachury, M., Nancey, S., Grange, F., Zallot, C., Peyrin-Biroulet, L., Rahier, J. F., de Beauregard, M. Bourdier, Mortier, L., Coutzac, C., Soularue, E., Lanoy, E., Kapel, N., Planchard, D., Chaput, N., Benson, Al B., Ajani, Jaffer A., Catalano, Robert B., Engelking, Constance, Kornblau, Steven M., Martenson, James A., McCallum, Richard, Mitchell, Edith P., O'Dorisio, Thomas M., Vokes, Everett E., Wadler, Scott, Haanen, J B A G, Kerr, K M, Peters, S, Larkin, J, Jordan, K, Bergqvist, Viktoria, Hertervig, Erik, Gedeon, Peter, Kopljar, Marija, Griph, Håkan, Kinhult, Sara, Carneiro, Ana, Marsal, Jan, Hsieh, Amy Hsin Chieh, Ferman, Mutaz, Brown, Michael P., Andrews, Jane M., Trainer, Harris, Hulse, Paul, Higham, Claire E, Trainer, Peter, Lorigan, Paul, Hughes, Jing, Vudattu, Nalini, Sznol, Mario, Gettinger, Scott, Kluger, Harriet, Lupsa, Beatrice, Herold, Kevan C

Publikováno v: Illouz, F, Wang, D Y, Ye, F, Zhao, S, Johnson, D B, Gupta, A, De Felice, K M, Loftus, E V, Khanna, S, Beck, K E, Blansfield, J A, Tran, K Q, Feldman, A L, Hughes, M S, Royal, R E, Kammula, U S, Topalian, S L, Sherry, R M, Kleiner, D, Quezado, M, Lowy, I, Yellin, M, Rosenberg, S A, Yang, J C, Michot, J M, Bigenwald, C, Champiat, S, Collins, M, Carbonnel, F, Postel-Vinay, S, Berdelou, A, Varga, A, Bahleda, R, Hollebecque, A, Massard, C, Fuerea, A, Ribrag, V, Gazzah, A, Armand, J P, Amellal, N, Angevin, E, Noel, N, Boutros, C, Mateus, C, Robert, C, Soria, J C, Marabelle, A, Lambotte, O, Gonzalez, R S, Salaria, S N, Bohannon, C D, Huber, A R, Feely, M M, Shi, C, Marthey, L, Mateus, C, Mussini, C, Nachury, M, Nancey, S, Grange, F, Zallot, C, Peyrin-Biroulet, L, Rahier, J F, de Beauregard, M B, Mortier, L, Coutzac, C, Soularue, E, Lanoy, E, Kapel, N, Planchard, D, Chaput, N, Robert, C, Carbonnel, F, Benson, A B, Ajani, J A, Catalano, R B, Engelking, C, Kornblau, S M, Martenson, J A, McCallum, R, Mitchell, E P, O'Dorisio, T M, Vokes, E E, Wadler, S, Haanen, J B A G, Carbonnel, F, Robert, C, Kerr, K M, Peters, S, Larkin, J, Jordan, K, Bergqvist, V, Hertervig, E, Gedeon, P, Kopljar, M, Griph, H, Kinhult, S, Carneiro, A, Marsal, J, Hsieh, A H C, Ferman, M, Brown, M P, Andrews, J M, Trainer, H, Hulse, P, Higham, C E, Trainer, P, Lorigan, P, Hughes, J, Vudattu, N, Sznol, M, Gettinger, S, Kluger, H, Lupsa, B & Herold, K C 2006, ' Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4 ', Journal of Clinical Oncology, pp. 2283-2289 . https://doi.org/10.1200/JCO.2005.04.5716

PurposeCytotoxic T-lymphocyte–associated antigen 4 (CTLA4) is an inhibitory receptor on T cells. Knocking out CTLA4 in mice causes lethal lymphoproliferation, and polymorphisms in human CTLA4 are associated with autoimmune disease. Trials of the an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f963594b903746c33682947dc0a8bf
https://doi.org/10.1200/jco.2005.04.5716

Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer.

Autor: Blansfield JA; Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1201, USA., Beck KE, Tran K, Yang JC, Hughes MS, Kammula US, Royal RE, Topalian SL, Haworth LR, Levy C, Rosenberg SA, Sherry RM

Publikováno v: Journal of immunotherapy (Hagerstown, Md. : 1997) [J Immunother] 2005 Nov-Dec; Vol. 28 (6), pp. 593-8.