Differential ion mobility spectroscopy: non-invasive real-time diagnostics and therapy control in metabolic diseases

Autor: Kikowatz A, Becher G, Dietze S, Steinhausser W, Beck E

Publikováno v: European Journal of Medical Research, Vol 14, Iss Suppl 4, Pp 121-125 (2009)

Abstract Background Over the last few years, differential ion mobility spectroscopy (DMS) has become an important tool in medical research. There are attempts to find markers for specific diseases in exhaled air, using this technology as a non-invasi

Externí odkaz: https://doaj.org/article/6dade5277c744716a705e1be6a4941db

Comparative Genetic Analysis of Psoriatic Arthritis and Psoriasis for the Discovery of Genetic Risk Factors and Risk Prediction Modeling

Autor: Soomro, M, Stadler, M, Dand, N, Bluett, J, Jadon, D, Jalali‐najafabadi, F, Duckworth, M, Ho, P, Marzo‐Ortega, H, Helliwell, PS, Ryan, AW, Kane, D, Korendowych, E, Simpson, MA, Packham, J, McManus, R, Gabay, C, Lamacchia, C, Nissen, MJ, Brown, MA, Verstappen, SMM, Van Staa, T, Barker, JN, Smith, CH, Chalmers, R, Flohr, C, Watson, K, Prieto‐Merino, D, Alabas, O, Barker, J, Becher, G, Bewley, A, Burden, D, Morrison, S, Laws, P, Evans, I, Griffiths, C, Ahmed, S, Kirby, B, Kleyn, E, Lawson, L, Mackenzie, T, McPherson, T, McElhone, K, Murphy, R, Ormerod, A, Owen, C, Reynolds, N, Rashid, A, Smith, C, Warren, R, Siebert, S, Brown, S, McAteer, H, Schofield, J, FitzGerald, O, McHugh, N, Warren, RB, Bowes, J, Barton, A

Objectives Psoriatic arthritis (PsA) has a strong genetic component, and the identification of genetic risk factors could help identify the ~30% of psoriasis patients at high risk of developing PsA. Our objectives were to identify genetic risk factor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::f08440eaf5186fd6994b5803172b23bb

Anakinra for palmoplantar pustulosis: results from a randomized, double-blind, multicentre, two-staged, adaptive placebo-controlled trial (APRICOT)

Autor: Cro, S, Cornelius, VR, Pink, AE, Wilson, R, Pushpa-Rajah, A, Patel, P, Abdul-Wahab, A, August, S, Azad, J, Becher, G, Chapman, A, Dunnil, G, Ferguson, AD, Fogo, A, Ghaffar, SA, Ingram, JR, Kavakleiva, S, Ladoyanni, E, Leman, JA, Macbeth, AE, Makrygeoegou, A, Parslew, R, Ryan, AJ, Sharma, A, Shipman, AR, Sinclair, C, Wachsmuth, R, Woolf, RT, Wright, A, McAteer, H, Barker, JNWN, Burden, AD, Griffiths, CEM, Reynolds, NJ, Warren, RB, Lachmann, HJ, Capon, F, Smith, CH, APRICOT Study Group

Publikováno v: The British journal of dermatology.

BACKGROUND Palmoplantar pustulosis (PPP) is a rare, debilitating, chronic inflammatory skin disease that affects the hands and feet. Clinical, immunological and genetic findings suggest a pathogenic role for interleukin (IL)-1. OBJECTIVES To determin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ab57fe1a0bd3e580fd96eb5a45add84
https://pubmed.ncbi.nlm.nih.gov/34878653

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Using Real-World Data to Guide Ustekinumab Dosing Strategies for Psoriasis: A Prospective Pharmacokinetic-Pharmacodynamic Study

Autor: Pan, S., Tsakok, T., Dand, N., Lonsdale, D.O., Loeff, F.C., Bloem, K., de Vries, A., Baudry, D., Duckworth, M., Mahil, S., Pushpa-Rajah, A., Russell, A., Alsharqi, A., Becher, G., Murphy, R., Wahie, S., Wright, A., Griffiths, C.E.M., Reynolds, N.J., Barker, J., Warren, R.B., David Burden, A., Rispens, T., Standing, J.F., Smith, C.H., Benham, M., Evans, I., Hussain, S., Kirby, B., Lawson, L., Mason, K., McElhone, K., Ormerod, A., Owen, C., Barnes, M.R., Di Meglio, P., Emsley, R., Evans, A., Payne, K.

Publikováno v: CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 13(2), 400-409. Wiley-Blackwell
Clinical and Translational Science, Vol 13, Iss 2, Pp 400-409 (2020)
Clinical and Translational Science
Pan, S, Tsakok, T, Dand, N, Lonsdale, D O, Loeff, F C, Bloem, K, de Vries, A, Baudry, D, Duckworth, M, Mahil, S, Pushpa-Rajah, A, Russell, A, Alsharqi, A, Becher, G, Murphy, R, Wahie, S, Wright, A, Griffiths, C E M, Reynolds, N J, Barker, J, Warren, R B, David Burden, A, Rispens, T & Standing, J F & Smith, C H 2020, ' Using Real-World Data to Guide Ustekinumab Dosing Strategies for Psoriasis : A Prospective Pharmacokinetic-Pharmacodynamic Study ', Clinical and Translational Science, vol. 13, no. 2, pp. 400-409 . https://doi.org/10.1111/cts.12725, https://doi.org/10.1111/cts.12725
Pan, S, Tsakok, T, Dand, N, Lonsdale, D O, Loeff, F C, Bloem, K, de Vries, A, Baudry, D, Duckworth, M, Mahil, S, Pushpa-Rajah, A, Russell, A, Alsharqi, A, Becher, G, Murphy, R, Wahie, S, Wright, A, Griffiths, C E M, Reynolds, N J, Barker, J, Warren, R B, David Burden, A, Rispens, T, Standing, J F, Smith, C H, Benham, M, Evans, I, Hussain, S, Kirby, B, Lawson, L, Mason, K, McElhone, K, Ormerod, A, Owen, C, Barnes, M R, Di Meglio, P, Emsley, R, Evans, A & Payne, K 2020, ' Using Real-World Data to Guide Ustekinumab Dosing Strategies for Psoriasis: A Prospective Pharmacokinetic-Pharmacodynamic Study ', Clinical and Translational Science, vol. 13, no. 2, pp. 400-409 . https://doi.org/10.1111/cts.12725

Variation in response to biologic therapy for inflammatory diseases, such as psoriasis, is partly driven by variation in drug exposure. Real-world psoriasis data were used to develop a pharmacokinetic/pharmacodynamic (PK/PD) model for the first-line

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bcea23ca63518fef3372a4c62f0df85
https://pure.amc.nl/en/publications/using-realworld-data-to-guide-ustekinumab-dosing-strategies-for-psoriasis(356fdda6-87b8-4fbc-8cc1-218c18c81fd8).html