Zobrazeno 1 - 10
of 227
pro vyhledávání: '"Bechara, Kachar"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract During hair cell development, the mechanoelectrical transduction (MET) apparatus is assembled at the stereocilia tips, where it coexists with the stereocilia actin regulatory machinery. While the myosin-based tipward transport of actin regul
Externí odkaz:
https://doaj.org/article/45ce34e9424e4923bd57114f2fb7782b
Autor:
Sihan Li, Andrew Mecca, Jeewoo Kim, Giusy A. Caprara, Elizabeth L. Wagner, Ting-Ting Du, Leonid Petrov, Wenhao Xu, Runjia Cui, Ivan T. Rebustini, Bechara Kachar, Anthony W. Peng, Jung-Bum Shin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
How the ear achieves its remarkable sensitivity is still not fully understood. In this study, the authors demonstrate that the deafness protein myosin-VIIa and its isoforms are essential for tensioning the tip link, thereby sensitizing the auditory r
Externí odkaz:
https://doaj.org/article/1e1c4ebb707d4e36929a5c7886e6304d
Autor:
Ting-Ting Du, James B. Dewey, Elizabeth L. Wagner, Runjia Cui, Jinho Heo, Jeong-Jin Park, Shimon P. Francis, Edward Perez-Reyes, Stacey J. Guillot, Nicholas E. Sherman, Wenhao Xu, John S Oghalai, Bechara Kachar, Jung-Bum Shin
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
In contrast to the extensively studied mechanosensory hair bundle, the cuticular plate is not as well understood. In this study, authors describe the discovery of a hair cell protein called LIM only protein 7, which is localized in the cuticular plat
Externí odkaz:
https://doaj.org/article/c2ec714b45bc41bf96953f0212beec8a
Autor:
Maryline Beurg, Runjia Cui, Adam C. Goldring, Seham Ebrahim, Robert Fettiplace, Bechara Kachar
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Mechanoelectrical transduction channel (MET) current found in stereocilia of hair cells matures over the first postnatal week. Here the authors look at the contribution of transmembrane channel-like protein 1 and 2 (TMC1 and TMC2) to MET current duri
Externí odkaz:
https://doaj.org/article/bacae67fdd6c42838993433203576aed
Autor:
Seham Ebrahim, Neil J. Ingham, Morag A. Lewis, Michael J.C. Rogers, Runjia Cui, Bechara Kachar, Johanna C. Pass, Karen P. Steel
Publikováno v:
Cell Reports, Vol 15, Iss 5, Pp 935-943 (2016)
WHRN (DFNB31) mutations cause diverse hearing disorders: profound deafness (DFNB31) or variable hearing loss in Usher syndrome type II. The known role of WHRN in stereocilia elongation does not explain these different pathophysiologies. Using spontan
Externí odkaz:
https://doaj.org/article/69f48714823d47469925259701d83447
Autor:
Seham Ebrahim, Matthew R. Avenarius, M’hamed Grati, Jocelyn F. Krey, Alanna M. Windsor, Aurea D. Sousa, Angela Ballesteros, Runjia Cui, Bryan A. Millis, Felipe T. Salles, Michelle A. Baird, Michael W. Davidson, Sherri M. Jones, Dongseok Choi, Lijin Dong, Manmeet H. Raval, Christopher M. Yengo, Peter G. Barr-Gillespie, Bechara Kachar
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
Stereocilia of the inner ear have graded heights that are thought to be regulated by the myosin-III family members MYO3A and MYO3B. Here the authors identify espin-1 and espin-like (ESPNL) as cargo that differentially influence the functions of both
Externí odkaz:
https://doaj.org/article/42f55193d572437c9f31dff7d2836595
Autor:
Satoe Takahashi, Willy Sun, Yingjie Zhou, Kazuaki Homma, Bechara Kachar, Mary Ann Cheatham, Jing Zheng
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Outer hair cells (OHC) act as amplifiers and their function is modified by medial olivocochlear (MOC) efferents. The unique OHC motor protein, prestin, provides the molecular basis for somatic electromotility, which is required for sensitivity and fr
Externí odkaz:
https://doaj.org/article/1406ca1212c64b7ba1d5dc7e25b26a41
Autor:
Lars Becker, Michael E Schnee, Mamiko Niwa, Willy Sun, Stephan Maxeiner, Sara Talaei, Bechara Kachar, Mark A Rutherford, Anthony J Ricci
Publikováno v:
eLife, Vol 7 (2018)
The ribbon is the structural hallmark of cochlear inner hair cell (IHC) afferent synapses, yet its role in information transfer to spiral ganglion neurons (SGNs) remains unclear. We investigated the ribbon’s contribution to IHC synapse formation an
Externí odkaz:
https://doaj.org/article/5c3ed910393a4578ac965be0a8cadbb6
Autor:
Kiyoto Kurima, Seham Ebrahim, Bifeng Pan, Miloslav Sedlacek, Prabuddha Sengupta, Bryan A. Millis, Runjia Cui, Hiroshi Nakanishi, Taro Fujikawa, Yoshiyuki Kawashima, Byung Yoon Choi, Kelly Monahan, Jeffrey R. Holt, Andrew J. Griffith, Bechara Kachar
Publikováno v:
Cell Reports, Vol 12, Iss 10, Pp 1606-1617 (2015)
Mechanosensitive ion channels at stereocilia tips mediate mechanoelectrical transduction (MET) in inner ear sensory hair cells. Transmembrane channel-like 1 and 2 (TMC1 and TMC2) are essential for MET and are hypothesized to be components of the MET
Externí odkaz:
https://doaj.org/article/956b6b945a184c899793d843c0c644ab
Autor:
Kimberlee P. Giffen, Yi Li, Huizhan Liu, Xiao-Chang Zhao, Chang-Jun Zhang, Ren-Juan Shen, Tianying Wang, Amanda Janesick, Bo-Bei Chen, Shu-Sheng Gong, Bechara Kachar, Zi-Bing Jin, David Z. He
Publikováno v:
Science Advances. 8
Lysosomes contribute to cellular homeostasis via processes including macromolecule degradation, nutrient sensing, and autophagy. Defective proteins related to lysosomal macromolecule catabolism are known to cause a range of lysosomal storage diseases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c55172e746bec72f73ccc8dd6c3d0a7f
https://doi.org/10.1126/sciadv.abk0942
https://doi.org/10.1126/sciadv.abk0942