Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Becca V. Baby"'
Autor:
Balaji Chandrasekaran, Ashish Tyagi, Uttara Saran, Venkatesh Kolluru, Becca V. Baby, Venkat R. Chirasani, Nikolay V. Dokholyan, Jyh M. Lin, Amandeep Singh, Arun K. Sharma, Murali K. Ankem, Chendil Damodaran
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
We investigated the efficacy of a small molecule ASR-600, an analog of Urolithin A (Uro A), on blocking androgen receptor (AR) and its splice variant AR-variant 7 (AR-V7) signaling in castration-resistant prostate cancer (CRPC). ASR-600 effectively s
Externí odkaz:
https://doaj.org/article/3c39b919e8a144f49978bb9232157b3f
Autor:
Rabindra K. Mandal, Joshua E. Denny, Morgan L. Waide, Qingsheng Li, Neal Bhutiani, Charles D. Anderson, Becca V. Baby, Venkatakrishna R. Jala, Nejat K. Egilmez, Nathan W. Schmidt
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-12 (2020)
Abstract Background Experimental reproducibility in mouse models is impacted by both genetics and environment. The generation of reproducible data is critical for the biomedical enterprise and has become a major concern for the scientific community a
Externí odkaz:
https://doaj.org/article/37179ee1f5204fa8b64bd65d87a079bc
Autor:
Niranjan G. Kotla, Isma Liza Mohd Isa, Swetha Rasala, Secil Demir, Rajbir Singh, Becca V. Baby, Samantha K. Swamy, Peter Dockery, Venkatakrishna R. Jala, Yury Rochev, Abhay Pandit
Publikováno v:
Advanced Science, Vol 9, Iss 4, Pp n/a-n/a (2022)
Abstract The active stages of intestinal inflammation and the pathogenesis of ulcerative colitis are associated with superficial mucosal damage and intermittent wounding that leads to epithelial barrier defects and increased permeability. The standar
Externí odkaz:
https://doaj.org/article/92aa1c0cb52b4eafb1c3f8314976d526
Autor:
Rajbir Singh, Sandeep Chandrashekharappa, Sobha R. Bodduluri, Becca V. Baby, Bindu Hegde, Niranjan G. Kotla, Ankita A. Hiwale, Taslimarif Saiyed, Paresh Patel, Matam Vijay-Kumar, Morgan G. I. Langille, Gavin M. Douglas, Xi Cheng, Eric C. Rouchka, Sabine J. Waigel, Gerald W. Dryden, Houda Alatassi, Huang-Ge Zhang, Bodduluri Haribabu, Praveen K. Vemula, Venkatakrishna R. Jala
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Urolithins are microbial metabolites derived from food polyphenols. Here, Singh et al. show that urolithin A and a synthetic analogue enhance gut barrier function via Nrf2-dependent pathways and mitigate inflammation and colitis in mice, highlighting
Externí odkaz:
https://doaj.org/article/7744317287314ef5850cd0de51ff17e3
Autor:
Chendil Damodaran, Arun K. Sharma, Nikolay V. Dokholyan, Venkat R. Chirasani, Srinivasa R. Ramisetti, Murali K. Ankem, Cibi A. Sripathi, Becca V. Baby, Venkatesh Kolluru, Balaji Chandrasekaran, Ashish Tyagi
Supplementary Files
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fd17fe8a233929b58764f877b0544c7
https://doi.org/10.1158/1535-7163.22519455.v1
https://doi.org/10.1158/1535-7163.22519455.v1
Autor:
Ashish Tyagi, Becca V. Baby, Venkat R. Chirasani, Cibi A. Sripathi, Chendil Damodaran, Murali K. Ankem, Arun Sharma, Venkatesh Kolluru, Balaji Chandrasekaran, Nikolay V. Dokholyan, Srinivasa R. Ramisetti
Publikováno v:
Molecular Cancer Therapeutics. 19:2422-2431
Notch1 activation triggers significant oncogenic signaling that manifests as enhanced metastatic potential and tumorigenesis in colorectal cancer. Novel small-molecule inhibitors, mainly plant-derived analogs, have low toxicity profiles and higher bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb2389b2bdaad383725135e10511c315
https://doi.org/10.1158/1535-7163.mct-19-0949
https://doi.org/10.1158/1535-7163.mct-19-0949
Autor:
Niranjan G. Kotla, Isma Liza Mohd Isa, Swetha Rasala, Secil Demir, Rajbir Singh, Becca V. Baby, Samantha K. Swamy, Peter Dockery, Venkatakrishna R. Jala, Yury Rochev, Abhay Pandit
Publikováno v:
Adv Sci (Weinh)
Colon Mucosa Protecting HA‐Enema System In article number 2103189, Yury Rochev, Abhay Pandit, and co‐workers develop a biphasic HMW‐hyaluronan (HA) enema suspension that protects the dysregulated colitis colon epithelium. The developed HA‐bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68ed6b3ff9972adff2c2818c81dd39d2
https://europepmc.org/articles/PMC8811836/
https://europepmc.org/articles/PMC8811836/
Autor:
Eun Jung Kim, Becca V. Baby, Ronald C. Bruntz, Matthew S. Gentry, Lindsey R. Conroy, Mariana Barbosa de Souza Rizzo, Kelly M. McMasters, Jordan T. Noe, Anne E. Geller, Hayley C. Affronti, Beatriz E. Rendon, Lance A. Johnson, Ramon C. Sun, Brian F. Clem, Robert A. Mitchell, Kathryn E. Wellen, Samantha M. Morrissey, Lyndsay E.A. Young, Ashley Wise-Mitchell, Jun Yan, Eric R. Relich
Publikováno v:
Science Advances
Description
Macrophages use mitochondrial lactate metabolism for ACLY-dependent histone acetylation, immune suppression, and tumor progression.
Lactate accumulation is a hallmark of solid cancers and is linked to the immune suppressive phen
Macrophages use mitochondrial lactate metabolism for ACLY-dependent histone acetylation, immune suppression, and tumor progression.
Lactate accumulation is a hallmark of solid cancers and is linked to the immune suppressive phen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cef2f4357447b4899baec609965bd4b
https://doi.org/10.1126/sciadv.abi8602
https://doi.org/10.1126/sciadv.abi8602
Autor:
Morgan G. I. Langille, Eric C. Rouchka, Gavin M. Douglas, Taslimarif Saiyed, Gerald W. Dryden, Sobha R. Bodduluri, Paresh Patel, Praveen Kumar Vemula, Huang-Ge Zhang, Matam Vijay-Kumar, Ankita A. Hiwale, Sandeep Chandrashekharappa, Bindu Hegde, Becca V. Baby, Xi Cheng, Venkatakrishna R. Jala, Sabine Waigel, Bodduluri Haribabu, Rajbir Singh, Houda Alatassi, Niranjan G. Kotla
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Nature Communications
Nature Communications
The importance of gut microbiota in human health and pathophysiology is undisputable. Despite the abundance of metagenomics data, the functional dynamics of gut microbiota in human health and disease remain elusive. Urolithin A (UroA), a major microb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20c3704b24def8209e00f0ee08c8510e
http://link.springer.com/article/10.1038/s41467-018-07859-7
http://link.springer.com/article/10.1038/s41467-018-07859-7
Autor:
Joshua E. Denny, Morgan L Waide, Nejat K. Egilmez, Neal Bhutiani, Charles D. Anderson, Qingsheng Li, Rabindra K. Mandal, Becca V. Baby, Venkatakrishna R. Jala, Nathan W. Schmidt
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-12 (2020)
BMC Biology
BMC Biology
Background Experimental reproducibility in mouse models is impacted by both genetics and environment. The generation of reproducible data is critical for the biomedical enterprise and has become a major concern for the scientific community and fundin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1dce83acaf46dc5f29273a0e4c2400e
https://doi.org/10.1186/s12915-020-00810-7
https://doi.org/10.1186/s12915-020-00810-7