Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Becca, Asquith"'
Autor:
Laura Mora-Bitria, Becca Asquith
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
In addition to their central role during innate responses, NK cells regulate adaptive immunity through various mechanisms. A wide array of innate receptors has been involved in the NK cell regulatory function. However, the clinical implications of th
Externí odkaz:
https://doaj.org/article/3c840ebf4b5e47fb963966a1bb047bd7
Autor:
Yan Zhang, Ada W.C. Yan, Lies Boelen, Linda Hadcocks, Arafa Salam, Daniel Padrosa Gispert, Loiza Spanos, Laura Mora Bitria, Neda Nemat-Gorgani, James A. Traherne, Chrissy Roberts, Danai Koftori, Graham P. Taylor, Daniel Forton, Paul J. Norman, Steven G.E. Marsh, Robert Busch, Derek C. Macallan, Becca Asquith
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 12 (2023)
BACKGROUND There is increasing evidence, in transgenic mice and in vitro, that inhibitory killer cell immunoglobulin-like receptors (iKIRs) can modulate T cell responses. Furthermore, we have previously shown that iKIRs are an important determinant o
Externí odkaz:
https://doaj.org/article/200e61ac74c14f7eb11190bdd8c93c60
Autor:
Suzanne Day, Charandeep Kaur, Hannah M. Cheeseman, Emily de Groot, Leon R. McFarlane, Maniola Tanaka, Sofia Coelho, Tom Cole, Nana-Marie Lemm, Adrian Lim, Rogier W. Sanders, Becca Asquith, Robin J. Shattock, Katrina M. Pollock
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundHarnessing CD4+ T cell help in the lymph nodes through rational antigen design could enhance formation of broadly neutralizing antibodies (bNAbs) during experimental HIV immunization. This process has remained hidden due to difficulty with
Externí odkaz:
https://doaj.org/article/5c340f5221354a22b2a2a6910c089fd7
Autor:
Raya Ahmed, Kelly L. Miners, Julio Lahoz-Beneytez, Rhiannon E. Jones, Laureline Roger, Christina Baboonian, Yan Zhang, Eddie C.Y. Wang, Marc K. Hellerstein, Joseph M. McCune, Duncan M. Baird, David A. Price, Derek C. Macallan, Becca Asquith, Kristin Ladell
Publikováno v:
Cell Reports, Vol 33, Iss 11, Pp 108501- (2020)
Summary: A central paradigm in the field of lymphocyte biology asserts that replicatively senescent memory T cells express the carbohydrate epitope CD57. These cells nonetheless accumulate with age and expand numerically in response to persistent ant
Externí odkaz:
https://doaj.org/article/7885536d2b5e42149b0d76509a9181e5
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 9, p e1007470 (2020)
Human T-lymphotropic virus type-1 (HTLV-1) persists within hosts via infectious spread (de novo infection) and mitotic spread (infected cell proliferation), creating a population structure of multiple clones (infected cell populations with identical
Externí odkaz:
https://doaj.org/article/e1e25e519dff4dcca25f77616fdbd83c
Autor:
Pedro Costa del Amo, Bisrat Debebe, Milad Razavi-Mohseni, Shinji Nakaoka, Andrew Worth, Diana Wallace, Peter Beverley, Derek Macallan, Becca Asquith
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The processes governing lymphocyte fate (division, differentiation, and death), are typically assumed to be independent of cell age. This assumption has been challenged by a series of elegant studies which clearly show that, for murine cells in vitro
Externí odkaz:
https://doaj.org/article/5ecb89a9c35a4acd9a2bbd2040422dab
Autor:
Bisrat J Debebe, Lies Boelen, James C Lee, IAVI Protocol C Investigators, Chloe L Thio, Jacquie Astemborski, Gregory Kirk, Salim I Khakoo, Sharyne M Donfield, James J Goedert, Becca Asquith
Publikováno v:
eLife, Vol 9 (2020)
Variation in the risk and severity of many autoimmune diseases, malignancies and infections is strongly associated with polymorphisms at the HLA class I loci. These genetic associations provide a powerful opportunity for understanding the etiology of
Externí odkaz:
https://doaj.org/article/80d1c97097094dba96ff172beca27a0b
Autor:
Laura Mora-Bitria, Becca Asquith
Killer-cell immunoglobulin-like receptors (KIRs) are mainly expressed on natural killer (NK) cells and are key regulators of innate immune responses. NK cells are the first responders in the face of infection and help promote placentation during preg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3af02c811d29c157330c765103719c57
http://hdl.handle.net/10044/1/102748
http://hdl.handle.net/10044/1/102748
Autor:
Pedro Costa Del Amo, Julio Lahoz-Beneytez, Lies Boelen, Raya Ahmed, Kelly L Miners, Yan Zhang, Laureline Roger, Rhiannon E Jones, Silvia A Fuertes Marraco, Daniel E Speiser, Duncan M Baird, David A Price, Kristin Ladell, Derek Macallan, Becca Asquith
Publikováno v:
PLoS Biology, Vol 16, Iss 6, p e2005523 (2018)
Adaptive immunity relies on the generation and maintenance of memory T cells to provide protection against repeated antigen exposure. It has been hypothesised that a self-renewing population of T cells, named stem cell-like memory T (TSCM) cells, are
Externí odkaz:
https://doaj.org/article/c85bfaa7e2db4200835697b9df1f03c9
Publikováno v:
PLoS Pathogens, Vol 13, Iss 6, p e1006361 (2017)
The observation, by Alter et al., of the enrichment of NK cell "escape" variants in individuals carrying certain Killer-cell Immunoglobulin-like Receptor (KIR) genes is compelling evidence that natural killer (NK) cells exert selection pressure on HI
Externí odkaz:
https://doaj.org/article/83d6fdebebdc4d27862868f00c692c63