Disease progression strikingly differs in research and real-world Parkinson's populations.

Autor: Beaulieu-Jones BK; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, 02115, USA. beaulieujones@uchicago.edu.; APDA Center for Advanced Parkinson Research of Harvard Medical School and Brigham and Women's Hospital, Boston, MA, 02115, USA. beaulieujones@uchicago.edu.; Precision Neurology Program of Brigham & Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA. beaulieujones@uchicago.edu.; Department of Medicine, University of Chicago, Chicago, IL, 60615, USA. beaulieujones@uchicago.edu.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA. beaulieujones@uchicago.edu., Frau F; Sanofi R&D, Data and Data Science, Frankfurt, Germany., Bozzi S; Sanofi Health Economics and Value Assessment, Sanofi, Paris, France., Chandross KJ; Sanofi R&D, Bridgewater, NJ, USA., Peterschmitt MJ; Sanofi Genzyme, Clinical Development Neurology, Cambridge, MA, USA., Cohen C; Sanofi R&D, Paris, France., Coulovrat C; Sanofi Translational Sciences, Framingham, MA, 01701, USA., Kumar D; Sanofi Translational Sciences, Framingham, MA, 01701, USA., Kruger MJ; Sanofi Genzyme, Clinical Development Neurology, Cambridge, MA, USA., Lipnick SL; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, 02115, USA., Fitzsimmons L; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, 02115, USA., Kohane IS; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, 02115, USA., Scherzer CR; APDA Center for Advanced Parkinson Research of Harvard Medical School and Brigham and Women's Hospital, Boston, MA, 02115, USA. clemens.scherzer@yale.edu.; Precision Neurology Program of Brigham & Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA. clemens.scherzer@yale.edu.; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA. clemens.scherzer@yale.edu.

Publikováno v: NPJ Parkinson's disease [NPJ Parkinsons Dis] 2024 Mar 13; Vol. 10 (1), pp. 58. Date of Electronic Publication: 2024 Mar 13.

Predicting seizure recurrence after an initial seizure-like episode from routine clinical notes using large language models: a retrospective cohort study.

Autor: Beaulieu-Jones BK; Department of Medicine, University of Chicago, Chicago, IL, USA; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. Electronic address: beaulieujones@uchicago.edu., Villamar MF; Department of Neurology, The Warren Alpert Medical School of Brown University, Providence, RI, USA., Scordis P; UCB, Brussels, Belgium., Bartmann AP; UCB, Brussels, Belgium., Ali W; UCB, Brussels, Belgium., Wissel BD; Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Alsentzer E; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., de Jong J; UCB Biosciences, Monheim, Germany., Patra A; UCB, Brussels, Belgium., Kohane I; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.

Publikováno v: The Lancet. Digital health [Lancet Digit Health] 2023 Dec; Vol. 5 (12), pp. e882-e894.

Generate Analysis-Ready Data for Real-world Evidence: Tutorial for Harnessing Electronic Health Records With Advanced Informatic Technologies.

Autor: Hou J; Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, United States., Zhao R; Department of Medicine, University of British Columbia, Vancouver, BC, Canada., Gronsbell J; Department of Statistical Sciences, University of Toronto, Toronto, ON, Canada., Lin Y; Institute of Engineering Medicine, Beijing Institute of Technology, Beijing, China., Bonzel CL; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, United States., Zeng Q; Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, United States., Zhang S; School of Statistics, Renmin University of China, Bejing, China., Beaulieu-Jones BK; Department of Medicine, University of Chicago, Chicago, IL, United States., Weber GM; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, United States., Jemielita T; Merck & Co, Inc, Rahway, NJ, United States., Wan SS; Merck & Co, Inc, Rahway, NJ, United States., Hong C; Department of Biostatistics & Bioinformatics, Duke University, Durham, NC, United States., Cai T; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, United States., Wen J; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, United States., Ayakulangara Panickan V; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, United States., Liaw KL; Merck & Co, Inc, Rahway, NJ, United States., Liao K; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, United States.; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States., Cai T; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, United States.; Department of Biostatistics, Harvard TH Chan School of Public Health, Boston, MA, United States.

Publikováno v: Journal of medical Internet research [J Med Internet Res] 2023 May 25; Vol. 25, pp. e45662. Date of Electronic Publication: 2023 May 25.

Severity of Epilepsy and Response to Antiseizure Medications in Individuals With Multiple Sclerosis: Analysis of a Real-World Dataset.

Autor: Villamar MF; The Warren Alpert Medical School of Brown University, Providence, RI (MFV); Department of Neurology, Brigham and Women's Hospital, Boston, MA (MFV, RAS, PP, BKB-J); Department of Neurology, University of Pittsburgh Medical Center, PA (PP); and Department of Biomedical Informatics (IK, BKB-J), Harvard Medical School, Boston, MA., Sarkis RA; The Warren Alpert Medical School of Brown University, Providence, RI (MFV); Department of Neurology, Brigham and Women's Hospital, Boston, MA (MFV, RAS, PP, BKB-J); Department of Neurology, University of Pittsburgh Medical Center, PA (PP); and Department of Biomedical Informatics (IK, BKB-J), Harvard Medical School, Boston, MA., Pennell P; The Warren Alpert Medical School of Brown University, Providence, RI (MFV); Department of Neurology, Brigham and Women's Hospital, Boston, MA (MFV, RAS, PP, BKB-J); Department of Neurology, University of Pittsburgh Medical Center, PA (PP); and Department of Biomedical Informatics (IK, BKB-J), Harvard Medical School, Boston, MA., Kohane I; The Warren Alpert Medical School of Brown University, Providence, RI (MFV); Department of Neurology, Brigham and Women's Hospital, Boston, MA (MFV, RAS, PP, BKB-J); Department of Neurology, University of Pittsburgh Medical Center, PA (PP); and Department of Biomedical Informatics (IK, BKB-J), Harvard Medical School, Boston, MA., Beaulieu-Jones BK; The Warren Alpert Medical School of Brown University, Providence, RI (MFV); Department of Neurology, Brigham and Women's Hospital, Boston, MA (MFV, RAS, PP, BKB-J); Department of Neurology, University of Pittsburgh Medical Center, PA (PP); and Department of Biomedical Informatics (IK, BKB-J), Harvard Medical School, Boston, MA.

Publikováno v: Neurology. Clinical practice [Neurol Clin Pract] 2022 Aug; Vol. 12 (4), pp. e49-e57.

International comparisons of laboratory values from the 4CE collaborative to predict COVID-19 mortality.

Autor: Weber GM; Department of Biomedical Informatics, Harvard Medical School, Boston, USA., Hong C; Department of Biomedical Informatics, Harvard Medical School, Boston, USA.; Department of Biostatistics and Bioinformatics, Duke University, Durham, USA., Xia Z; Department of Neurology, University of Pittsburgh, Pittsburgh, USA., Palmer NP; Department of Biomedical Informatics, Harvard Medical School, Boston, USA., Avillach P; Department of Biomedical Informatics, Harvard Medical School, Boston, USA., L'Yi S; Department of Biomedical Informatics, Harvard Medical School, Boston, USA., Keller MS; Department of Biomedical Informatics, Harvard Medical School, Boston, USA., Murphy SN; Department of Neurology, Massachusetts General Hospital, Boston, USA., Gutiérrez-Sacristán A; Department of Biomedical Informatics, Harvard Medical School, Boston, USA., Bonzel CL; Department of Biomedical Informatics, Harvard Medical School, Boston, USA., Serret-Larmande A; Department of biomedical informatics, Hôpital Européen Georges Pompidou, Assistance Publique - Hôpitaux de Paris, Paris, France., Neuraz A; Department of biomedical informatics, Hôpital Necker-Enfants Malade, Assistance Publique Hôpitaux de Paris (APHP), University of Paris, Paris, France., Omenn GS; Department of Computational Medicine & Bioinformatics, Internal Medicine, Human Genetics, and School of Public Health, University of Michigan, Ann Arbor, USA., Visweswaran S; Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, USA., Klann JG; Department of Medicine, Massachusetts General Hospital, Boston, USA., South AM; Department of Pediatrics-Section of Nephrology, Brenner Children's Hospital, Wake Forest School of Medicine, Winston Salem, USA., Loh NHW; Department of Anaesthesia, National University Health System, Singapore, Singapore, Singapore., Cannataro M; Department of Medical and Surgical Sciences, Data Analytics Research Center, University Magna Graecia of Catanzaro, Italy, Catanzaro, Italy., Beaulieu-Jones BK; Department of Biomedical Informatics, Harvard Medical School, Boston, USA., Bellazzi R; Department of Electrical, Computer and Biomedical Engineering, University of Pavia, Italy, Pavia, Italy., Agapito G; Department of Legal, Economic and Social Sciences, University Magna Graecia of Catanzaro, Italy, Catanzaro, Italy., Alessiani M; Department of Surgery, ASST Pavia, Lombardia Region Health System, Pavia, Italy., Aronow BJ; Departments of Biomedical Informatics, Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, USA., Bell DS; Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, USA., Benoit V; IT department, Innovation & Data, APHP Greater Paris University Hospital, Paris, France., Bourgeois FT; Department of Pediatrics, Harvard Medical School, Boston, USA., Chiovato L; Unit of Internal Medicine and Endocrinology, Istituti Clinici Scientifici Maugeri SpA SB IRCCS, Pavia, Italy., Cho K; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, USA., Dagliati A; Department of Electrical Computer and Biomedical Engineering, University of Pavia, Italy, Pavia, Italy., DuVall SL; VA Informatics and Computing Infrastructure, VA Salt Lake City Health Care System, Salt Lake City, USA., Barrio NG; Health Informatics, Hospital Universitario 12 de Octubre, Madrid, Spain., Hanauer DA; Department of Learning Health Sciences, University of Michigan, Ann Arbor, USA., Ho YL; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, USA., Holmes JH; Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA.; Institute for Biomedical Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA., Issitt RW; Digital Research, Informatics and Virtual Environments (DRIVE), Great Ormond Street Hospital for Children, UK, London, UK., Liu M; Department of Biostatistics, Harvard School of Public Health, Boston, USA., Luo Y; Department of Preventive Medicine, Northwestern University, Chicago, USA., Lynch KE; VA Informatics and Computing Infrastructure, VA Salt Lake City Health Care System, Salt Lake City, USA., Maidlow SE; Michigan Institute for Clinical and Health Research, University of Michigan, Ann Arbor, USA., Malovini A; Laboratory of Informatics and Systems Engineering for Clinical Research, Istituti Clinici Scientifici Maugeri SpA SB IRCCS, Pavia, Italy., Mandl KD; Computational Health Informatics Program, Boston Children's Hospital, Boston, USA., Mao C; Department of Preventive Medicine, Northwestern University, Chicago, USA., Matheny ME; VA Informatics and Computing Infrastructure, Tennessee Valley Healthcare System Veterans Affairs Medical Center, Nashville, USA., Moore JH; Institute for Biomedical Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA., Morris JS; Department of Biostatistics, Epidemiology, and Biostatistics, University of Pennysylvania Perelman School of Medicine, Philadelphia, USA., Morris M; Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, USA., Mowery DL; Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA., Ngiam KY; Department of Biomedical informatics, WiSDM, National University Health Systems Singapore, Singapore, Singapore., Patel LP; Department of Internal Medicine, Division of Medical Informatics, University of Kansas Medical Center, Kansas City, USA., Pedrera-Jimenez M; Health Informatics, Hospital Universitario 12 de Octubre, Madrid, Spain., Ramoni RB; Office of Research and Development, Department of Veterans Affairs, Washington, DC, USA., Schriver ER; Data Analytics Center, University of Pennsylvania Health System, Philadelphia, USA., Schubert P; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, USA., Balazote PS; Health Informatics, Hospital Universitario 12 de Octubre, Madrid, Spain., Spiridou A; Digital Research, Informatics and Virtual Environments (DRIVE), Great Ormond Street Hospital for Children, UK, London, UK., Tan ALM; Department of Biomedical Informatics, Harvard Medical School, Boston, USA., Tan BWL; Department of Medicine, National University Hospital, Singapore, Singapore, Singapore., Tibollo V; Laboratory of Informatics and Systems Engineering for Clinical Research, Istituti Clinici Scientifici Maugeri SpA SB IRCCS, Pavia, Italy., Torti C; Department of Medical and Surgical Sciences, Infectious and Tropical Disease Unit, University Magna Graecia of Catanzaro, Italy, Catanzaro, Italy., Trecarichi EM; Department of Medical and Surgical Sciences, Infectious and Tropical Disease Unit, University Magna Graecia of Catanzaro, Italy, Catanzaro, Italy., Wang X; Department of Biomedical Informatics, Harvard Medical School, Boston, USA., Kohane IS; Department of Biomedical Informatics, Harvard Medical School, Boston, USA., Cai T; Department of Biomedical Informatics, Harvard Medical School, Boston, USA. tcai@hsph.harvard.edu., Brat GA; Department of Biomedical Informatics, Harvard Medical School, Boston, USA. gabriel_brat@hms.harvard.edu.

Publikováno v: NPJ digital medicine [NPJ Digit Med] 2022 Jun 13; Vol. 5 (1), pp. 74. Date of Electronic Publication: 2022 Jun 13.