Identification and multimodal characterization of a specialized epithelial cell type associated with Crohn's disease.

Autor: Li J; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Simmons AJ; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Hawkins CV; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Chiron S; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Ramirez-Solano MA; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Tasneem N; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Kaur H; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Program in Chemical and Physical Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Xu Y; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Revetta F; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Vega PN; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Bao S; Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, USA., Cui C; Department of Computer Science, Vanderbilt University, Nashville, TN, USA., Tyree RN; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Raber LW; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Conner AN; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Pilat JM; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Jacobse J; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., McNamara KM; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Allaman MM; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Raffa GA; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Gobert AP; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, USA., Asim M; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Goettel JA; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, USA., Choksi YA; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, USA.; Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN, USA., Beaulieu DB; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Dalal RL; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Horst SN; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Pabla BS; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Huo Y; Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, USA.; Department of Computer Science, Vanderbilt University, Nashville, TN, USA., Landman BA; Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, USA.; Department of Computer Science, Vanderbilt University, Nashville, TN, USA., Roland JT; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA., Scoville EA; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, USA., Schwartz DA; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Washington MK; Program in Chemical and Physical Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, USA., Shyr Y; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA., Wilson KT; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. keith.wilson@vumc.org.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA. keith.wilson@vumc.org.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, USA. keith.wilson@vumc.org.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, USA. keith.wilson@vumc.org.; Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN, USA. keith.wilson@vumc.org., Coburn LA; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. lori.coburn@vumc.org.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, USA. lori.coburn@vumc.org.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, USA. lori.coburn@vumc.org.; Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN, USA. lori.coburn@vumc.org., Lau KS; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN, USA. ken.s.lau@vanderbilt.edu.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA. ken.s.lau@vanderbilt.edu.; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA. ken.s.lau@vanderbilt.edu.; Program in Chemical and Physical Biology, Vanderbilt University School of Medicine, Nashville, TN, USA. ken.s.lau@vanderbilt.edu.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, TN, USA. ken.s.lau@vanderbilt.edu.; Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA. ken.s.lau@vanderbilt.edu., Liu Q; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN, USA. qi.liu@vumc.org.; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA. qi.liu@vumc.org.

Publikováno v: Nature communications [Nat Commun] 2024 Aug 22; Vol. 15 (1), pp. 7204. Date of Electronic Publication: 2024 Aug 22.

Maternal and Neonatal Outcomes in Vedolizumab- and Ustekinumab-Exposed Pregnancies: Results From the PIANO Registry.

Autor: Chugh R; Division of Gastroenterology and Hepatology, University of California San Francisco, San Francisco, California, USA., Long MD; Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, North Carolina, USA., Jiang Y; Department of Statistical Science, Duke University, Durham, North Carolina, USA., Weaver KN; Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, North Carolina, USA., Beaulieu DB; Division of Gastroenterology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Scherl EJ; Division of Gastroenterology, Weill Cornell Medicine, New York Presbyterian Hospital, New York, New York, USA., Mahadevan U; Division of Gastroenterology and Hepatology, University of California San Francisco, San Francisco, California, USA.

Publikováno v: The American journal of gastroenterology [Am J Gastroenterol] 2024 Mar 01; Vol. 119 (3), pp. 468-476. Date of Electronic Publication: 2023 Oct 05.

A Specialized Epithelial Cell Type Regulating Mucosal Immunity and Driving Human Crohn's Disease.

Autor: Li J; Center for Quantitative Sciences, Vanderbilt Univerity Medical Center, Nashville, TN, USA.; Department of Biostatistics, Vanderbilt Univerity Medical Center, Nashville, TN, USA., Simmons AJ; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Chiron S; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Ramirez-Solano MA; Center for Quantitative Sciences, Vanderbilt Univerity Medical Center, Nashville, TN, USA.; Department of Biostatistics, Vanderbilt Univerity Medical Center, Nashville, TN, USA., Tasneem N; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Kaur H; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Program in Chemical and Physical Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Xu Y; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Revetta F; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Vega PN; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA., Bao S; Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, USA.; Department of Computer Science, Vanderbilt University, Nashville, TN, USA., Cui C; Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, USA.; Department of Computer Science, Vanderbilt University, Nashville, TN, USA., Tyree RN; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Raber LW; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Conner AN; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Beaulieu DB; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Dalal RL; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Horst SN; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Pabla BS; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Huo Y; Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, USA.; Department of Computer Science, Vanderbilt University, Nashville, TN, USA., Landman BA; Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, USA.; Department of Computer Science, Vanderbilt University, Nashville, TN, USA., Roland JT; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Surgery, Vanderbilt University Medical Center, Nashville TN, USA., Scoville EA; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center; Nashville, TN, USA., Schwartz DA; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Washington MK; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center; Nashville, TN, USA., Shyr Y; Center for Quantitative Sciences, Vanderbilt Univerity Medical Center, Nashville, TN, USA.; Department of Biostatistics, Vanderbilt Univerity Medical Center, Nashville, TN, USA., Wilson KT; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.; Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN, USA.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center; Nashville, TN, USA., Coburn LA; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN, USA.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center; Nashville, TN, USA., Lau KS; Center for Quantitative Sciences, Vanderbilt Univerity Medical Center, Nashville, TN, USA.; Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.; Program in Chemical and Physical Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.; Department of Surgery, Vanderbilt University Medical Center, Nashville TN, USA.; Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center; Nashville, TN, USA., Liu Q; Center for Quantitative Sciences, Vanderbilt Univerity Medical Center, Nashville, TN, USA.; Department of Biostatistics, Vanderbilt Univerity Medical Center, Nashville, TN, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Oct 02. Date of Electronic Publication: 2023 Oct 02.

Multicenter Study of Nonadherence to Self-Injectable Biologic Therapy in Patients With Inflammatory Bowel Disease: Risk Factors and Outcomes.

Autor: George LA; Division of Gastroenterology & Hepatology, University of Maryland School of Medicine, Baltimore, Maryland., Causey E; Division of Gastroenterology & Hepatology, University of Maryland School of Medicine, Baltimore, Maryland., Shah NB; Vanderbilt Specialty Pharmacy, Vanderbilt University Medical Center, Nashville, Tennessee., Slaughter JC; Division of Gastroenterology, Hepatology & Nutrition, Vanderbilt University Medical Center., Jerabek J; Division of Gastroenterology, Hepatology, & Nutrition, University of Minnesota, Minneapolis, Minnesota., Zuckerman AD; Vanderbilt Specialty Pharmacy, Vanderbilt University Medical Center, Nashville, Tennessee., Chhen S; Fairview Specialty Pharmacy, Minneapolis, Minnesota., Scoville E; Division of Gastroenterology, Hepatology & Nutrition, Vanderbilt University Medical Center., Dalal R; Division of Gastroenterology, Hepatology & Nutrition, Vanderbilt University Medical Center., Beaulieu DB; Division of Gastroenterology, Hepatology & Nutrition, Vanderbilt University Medical Center., Pabla B; Division of Gastroenterology, Hepatology & Nutrition, Vanderbilt University Medical Center., Schwartz DA; Division of Gastroenterology, Hepatology & Nutrition, Vanderbilt University Medical Center., Cross RK; Division of Gastroenterology & Hepatology, University of Maryland School of Medicine, Baltimore, Maryland., Vaughn BP; Division of Gastroenterology, Hepatology, & Nutrition, University of Minnesota, Minneapolis, Minnesota., Horst S; Division of Gastroenterology, Hepatology & Nutrition, Vanderbilt University Medical Center.

Publikováno v: Gastro hep advances [Gastro Hep Adv] 2023 Jan 30; Vol. 2 (4), pp. 601-607. Date of Electronic Publication: 2023 Jan 30 (Print Publication: 2023).

Safety and Efficacy of Vedolizumab Versus Tumor Necrosis Factor α Antagonists in an Elderly IBD Population: A Single Institution Retrospective Experience.

Autor: Pabla BS; Division of Internal Medicine, Department of Gastroenterology, Vanderbilt Inflammatory Bowel Diseases Center, Vanderbilt University Medical Center, 719 Thompson Lane, Suite 20500, Nashville, TN, 37204, USA. baldeep.pabla@vumc.org., Alex Wiles C; Department of Internal Medicine, Vanderbilt University Medical Center, Nashville, USA., Slaughter JC; Department of Biostatistics, Vanderbilt University, Nashville, USA., Scoville EA; Division of Internal Medicine, Department of Gastroenterology, Vanderbilt Inflammatory Bowel Diseases Center, Vanderbilt University Medical Center, 719 Thompson Lane, Suite 20500, Nashville, TN, 37204, USA., Dalal RL; Division of Internal Medicine, Department of Gastroenterology, Vanderbilt Inflammatory Bowel Diseases Center, Vanderbilt University Medical Center, 719 Thompson Lane, Suite 20500, Nashville, TN, 37204, USA., Beaulieu DB; Division of Internal Medicine, Department of Gastroenterology, Vanderbilt Inflammatory Bowel Diseases Center, Vanderbilt University Medical Center, 719 Thompson Lane, Suite 20500, Nashville, TN, 37204, USA., Schwartz DA; Division of Internal Medicine, Department of Gastroenterology, Vanderbilt Inflammatory Bowel Diseases Center, Vanderbilt University Medical Center, 719 Thompson Lane, Suite 20500, Nashville, TN, 37204, USA., Horst SN; Division of Internal Medicine, Department of Gastroenterology, Vanderbilt Inflammatory Bowel Diseases Center, Vanderbilt University Medical Center, 719 Thompson Lane, Suite 20500, Nashville, TN, 37204, USA.

Publikováno v: Digestive diseases and sciences [Dig Dis Sci] 2022 Jul; Vol. 67 (7), pp. 3129-3137. Date of Electronic Publication: 2021 Jul 15.