Zobrazeno 1 - 10
of 635
pro vyhledávání: '"Beau R"'
Autor:
Evan W. Kleinboehl, Kanut Laoharawee, Walker S. Lahr, Jacob D. Jensen, Joseph J. Peterson, Jason B. Bell, Beau R. Webber, Branden S. Moriarity
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101253- (2024)
CRISPR-Cas9 and novel cas fusion proteins leveraging specific DNA targeting ability combined with deaminases or reverse transcriptases have revolutionized genome editing. However, their efficacy heavily relies upon protein variants, targeting single
Externí odkaz:
https://doaj.org/article/16649dec265345ac871b9882d548f54a
Autor:
Cassandra Suther, Billie Alba, Beau R. Yurkevicius, Patrick N. Radcliffe, Heather S. Fagnant, John Castellani, J. Philip Karl
Publikováno v:
Journal of Nutritional Science, Vol 13 (2024)
Cocoa-derived flavanols (CDF) may act as prebiotics. However, evidence is inconsistent, and the duration and dose of CDF intake needed to elicit any prebiotic effect are undefined. This randomized, double-blind, crossover study determined the effects
Externí odkaz:
https://doaj.org/article/383f54065aea4ae9af01e746ee32d51c
Autor:
Meagan R. Rollins, Jackson F. Raynor, Ebony A. Miller, Jonah Z. Butler, Ellen J. Spartz, Walker S. Lahr, Yun You, Adam L. Burrack, Branden S. Moriarity, Beau R. Webber, Ingunn M. Stromnes
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
The currently available transgenic T cell receptor (TCR) models represent high affinity antigen-TCR interactions. Authors here present an alternative approach to target an exogenous TCR into the physiological Trac locus in the germline of mice, which
Externí odkaz:
https://doaj.org/article/f686ccd3ae77471d8e50f4e9b637e5d1
Autor:
Derek P. Wong, Nand K. Roy, Keman Zhang, Anusha Anukanth, Abhishek Asthana, Nicole J. Shirkey-Son, Samantha Dunmire, Bryan J. Jones, Walker S. Lahr, Beau R. Webber, Branden S. Moriarity, Paolo Caimi, Reshmi Parameswaran
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Antigen escape represents a potential drawback of chimeric antigen receptor T cell (CAR-T) therapy targeting a single tumor-associated antigen. To reduce the risk of antigen escape, here the authors report the design and characterization of a BAFF li
Externí odkaz:
https://doaj.org/article/c04ffe4059244b10af193f36e3666dbb
Autor:
Rachel M Moss, Kelsie Becklin, Lauren J Mills, Branden S Moriarity, Beau R Webber, Logan G Spector
Publikováno v:
Journal of Clinical and Translational Science, Vol 7, Pp 77-78 (2023)
OBJECTIVES/GOALS: We leverage the disparate incidence of Ewing sarcoma (ES) between European (EUR) and African (AFR) ancestry to study ES tumorigenesis in iPSC-derived cells from donors with a range of AFR ancestry via functional / molecular profilin
Externí odkaz:
https://doaj.org/article/e60b25c03477485fb436fb3c51435368
Autor:
Autumn Brostek, Nancy J. Hong, Ronghao Zhang, Beau R. Forester, Lauren E. Barmore, Lindsey Kaydo, Nicholas Kluge, Corey Smith, Jeffrey L. Garvin, Agustin Gonzalez‐Vicente
Publikováno v:
Physiological Reports, Vol 10, Iss 19, Pp n/a-n/a (2022)
Abstract Proximal tubule fructose metabolism is key to fructose‐induced hypertension, but the roles of sex and stress are unclear. We hypothesized that females are resistant to the salt‐sensitive hypertension caused by low amounts of dietary fruc
Externí odkaz:
https://doaj.org/article/ce6b04dce8884acba616e8aa7eef342c
Autor:
Mitchell G. Kluesner, Rafail Nikolaos Tasakis, Taga Lerner, Annette Arnold, Sandra Wüst, Marco Binder, Beau R. Webber, Branden S. Moriarity, Riccardo Pecori
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 25, Iss , Pp 515-523 (2021)
We present MultiEditR (Multiple Edit Deconvolution by Inference of Traces in R), the first algorithm specifically designed to detect and quantify RNA editing from Sanger sequencing (z.umn.edu/multieditr). Although RNA editing is routinely evaluated b
Externí odkaz:
https://doaj.org/article/6ae1106ace65443689c12fb1b0a3e6cd
Autor:
Claribel Murillo-Solano, Beau R. Brummel, David L. Perry, James R. Rocca, Debopam Chakrabarti
Publikováno v:
ACS Omega, Vol 6, Iss 31, Pp 20455-20470 (2021)
Externí odkaz:
https://doaj.org/article/f54a53c6a16648b8ba7b5b0303d98199
Autor:
Erdem D. Tabdanov, Nelson J. Rodríguez-Merced, Alexander X. Cartagena-Rivera, Vikram V. Puram, Mackenzie K. Callaway, Ethan A. Ensminger, Emily J. Pomeroy, Kenta Yamamoto, Walker S. Lahr, Beau R. Webber, Branden S. Moriarity, Alexander S. Zhovmer, Paolo P. Provenzano
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The mechanics of the migration of T cells into tumours is an important aspect of tumour immunity. Here the authors engineer complex 3D environments to explore functions of microtubules and cell contractility as strategies to enhance T cell migration
Externí odkaz:
https://doaj.org/article/a9258c06966543cda042cc7df55119b0
Autor:
Mitchell G. Kluesner, Walker S. Lahr, Cara-lin Lonetree, Branden A. Smeester, Xiaohong Qiu, Nicholas J. Slipek, Patricia N. Claudio Vázquez, Samuel P. Pitzen, Emily J. Pomeroy, Madison J. Vignes, Samantha C. Lee, Samuel P. Bingea, Aneesha A. Andrew, Beau R. Webber, Branden S. Moriarity
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Base editors can inactivate splice sites or introduce stop codons into a gene sequence. Here the authors present SpliceR to design, rank, and test sgRNAs for efficient gene disruption in T cells.
Externí odkaz:
https://doaj.org/article/66661828f7814bdf8c8c049d29a4b13b