Výsledky vyhledávání - "Beau Mitchell"

Akademický článek

Genetic disarray follows mutant KLF1-E325K expression in a congenital dyserythropoietic anemia patient

Autor: Lilian Varricchio, Antanas Planutis, Deepa Manwani, Julie Jaffray, W. Beau Mitchell, Anna Rita Migliaccio, James J. Bieker

Publikováno v: Haematologica, Vol 104, Iss 12 (2019)

Congenital dyserythropoietic anemia type IV is caused by a heterozygous mutation, Glu325Lys (E325K), in the KLF1 transcription factor. Molecular characteristics of this disease have not been clarified, partly due to its rarity. We expanded erythroid

Externí odkaz: https://doaj.org/article/e187420825ac46e888bd855ac18854de

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Akademický článek

Altered heme-mediated modulation of dendritic cell function in sickle cell alloimmunization

Autor: Emmanuelle Godefroy, Yunfeng Liu, Patricia Shi, W. Beau Mitchell, Devin Cohen, Stella T. Chou, Deepa Manwani, Karina Yazdanbakhsh

Publikováno v: Haematologica, Vol 101, Iss 9 (2016)

Transfusions are the main treatment for patients with sickle cell disease. However, alloimmunization remains a major life-threatening complication for these patients, but the mechanism underlying pathogenesis of alloimmunization is not known. Given t

Externí odkaz: https://doaj.org/article/b989cb07b5f84040b1c612efc40d7bd2

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Thromboinflammation in COVID-19 acute lung injury

Autor: William Beau Mitchell

Publikováno v: Paediatric Respiratory Reviews

Since the initial description in 2019, the novel coronavirus SARS-Cov-2 infection (COVID-19) pandemic has swept the globe. The most severe form of the disease presents with fever and shortness of breath, which rapidly deteriorates to respiratory fail

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4979b2f42ef01f5ecd03b9eb662ddf3d
https://doi.org/10.1016/j.prrv.2020.06.004

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Akademický článek

Use of thrombopoietin receptor agonists in childhood immune thrombocytopenia

Autor: Angelica Maria Garzon, William Beau Mitchell

Publikováno v: Frontiers in Pediatrics, Vol 3 (2015)

Most children with immune thrombocytopenia (ITP) will have spontaneous remission regardless of therapy, while about 20% will go on to have chronic ITP. In those children with chronic ITP who need treatment, standard therapies for acute ITP may have a

Externí odkaz: https://doaj.org/article/2c97e39741b94922abeab9aea7d3e6a9

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Akademický článek

Actin inhibition increases megakaryocyte proplatelet formation through an apoptosis-dependent mechanism.

Autor: Mauro P Avanzi, Marina Izak, Oluwasijibomi E Oluwadara, William Beau Mitchell

Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0125057 (2015)

BACKGROUND:Megakaryocytes assemble and release platelets through the extension of proplatelet processes, which are cytoplasmic extensions that extrude from the megakaryocyte and form platelets at their tips. Proplatelet formation and platelet release

Externí odkaz: https://doaj.org/article/4f00c03bdd2b4a7cac25209319a04245

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