Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Beatriz de la Puente"'
Autor:
Sergio López-Estévez, Mònica Aguilera, Georgia Gris, Beatriz de la Puente, Alicia Carceller, Vicente Martínez
Publikováno v:
Biomedicines, Vol 11, Iss 10, p 2758 (2023)
Sigma-1 receptors (σ1Rs) are implicated in nociception, including pain sensitization, and inflammation. We assessed the role of σ1Rs on acute colitis-associated hypersensitivity using both genetic (constitutive knockout) and pharmacological blockad
Externí odkaz:
https://doaj.org/article/6252f78898cc4ed49730a1cd9bcbc1d5
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 143, Iss , Pp 112126- (2021)
Sigma-1 receptors (σ1R) have been implicated in several pain pathways. We assessed the implication of σ1Rs in the development of intestinal inflammation and inflammation-associated referred hypersensitivity in a model of colitis in σ1R knockout (K
Externí odkaz:
https://doaj.org/article/5d9da1737045459c8a0bdfcbcafc7896
Decades of research on oncogene-driven carcinogenesis and gene-expression regulatory networks only started to unveil the complexity of tumour cellular and molecular biology. This knowledge has been successfully implemented in the clinical practice to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d43c4f66025a8e5eb67a8ee92dbb3330
https://hdl.handle.net/10481/80546
https://hdl.handle.net/10481/80546
Autor:
Antoni Torrens, José Miguel Vela, Adriana Lorente, Ana Montero, Sandra Yeste, Ana María Caamaño, Alba Vidal-Torres, J.L. Diaz, Juan Enjo, Miquel Martin, Carmen Almansa, Inés Álvarez, Cristina Sicre, Rafael Maldonado, Mónica García, Adriana Port, Cruz Miguel Cendán, Beatriz de la Puente
Publikováno v:
Journal of Medicinal Chemistry. 63:14979-14988
The synthesis and pharmacological activity of a new series of pyrazoles that led to the identification of 1-(4-(2-((1-(3,4-difluorophenyl)-1H-pyrazol-3-yl)methoxy)ethyl)piperazin-1-yl)ethanone (9k, EST64454) as a σ1 receptor (σ1R) antagonist clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::748bb7ac3f47098d47adb62f112a37c0
https://doi.org/10.1021/acs.jmedchem.0c01575
https://doi.org/10.1021/acs.jmedchem.0c01575
Autor:
Beatriz de la Puente, Daniel Zamanillo, Luz Romero, Alicia Carceller, José Miguel Vela, Manuel Merlos, Enrique Portillo-Salido
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] Chronic pain remains a major health problem and is currently facing slow drug innovation. New drug treatments should address not only the sensory-discriminative but also functional and motivational-affective components of chronic pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c73b26d29d9fc1fe08817532f8a40817
https://pubmed.ncbi.nlm.nih.gov/35434530
https://pubmed.ncbi.nlm.nih.gov/35434530
Publikováno v:
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Biomedicine & Pharmacotherapy, Vol 143, Iss, Pp 112126-(2021)
Universitat Autònoma de Barcelona
Biomedicine & Pharmacotherapy, Vol 143, Iss, Pp 112126-(2021)
Altres ajuts: acords transformatius de la UAB Ajuts: The present work was funded by Laboratories ESTEVE, Barcelona, Spain Sigma-1 receptors (σ1R) have been implicated in several pain pathways. We assessed the implication of σ1Rs in the development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f33e98a49b757b66eaab6be46f230340
https://ddd.uab.cat/record/248939
https://ddd.uab.cat/record/248939
Autor:
José Luis, Díaz, Mónica, García, Antoni, Torrens, Ana María, Caamaño, Juan, Enjo, Cristina, Sicre, Adriana, Lorente, Adriana, Port, Ana, Montero, Sandra, Yeste, Inés, Álvarez, Miquel, Martín, Rafael, Maldonado, Beatriz, de la Puente, Alba, Vidal-Torres, Cruz Miguel, Cendán, José Miguel, Vela, Carmen, Almansa
Publikováno v:
Journal of medicinal chemistry. 63(23)
The synthesis and pharmacological activity of a new series of pyrazoles that led to the identification of 1-(4-(2-((1-(3,4-difluorophenyl)-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a21267337558c9ea591c3d747056e49e
https://pubmed.ncbi.nlm.nih.gov/33237785
https://pubmed.ncbi.nlm.nih.gov/33237785
Autor:
Julio César De Luca, Teresita Beatriz de la Puente, Graciela Eugenia Bianco, Lauro Cazón, Marcelo Rafael Benitez Ahrendts, Eva Suarez
Publikováno v:
Environmental Science and Pollution Research. 24:21146-21152
Little is known about biosecurity measures and toxic effects during pesticide application in the province of Jujuy, Argentina, particularly concerning the protective measures and mixture of pesticides used by rural workers. We carried out an observat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a23080535417572489b4490f0ccd091
https://doi.org/10.1007/s11356-017-9664-3
https://doi.org/10.1007/s11356-017-9664-3
Autor:
Enrique Portillo-Salido, Beatriz de la Puente, Daniel Zamanillo, José Miguel Vela, Manuel Merlos, Luz Romero
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Pain encompasses both sensory and affective dimensions which can be differentially modulated by drugs. Here, we compare the pharmacological sensitivity of the sensory and affective responses using acetic acid-induced abdominal writhings (sensory-refl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab31b9329e2b4cd3643ffbccd183464a
https://doi.org/10.1038/s41598-017-13987-9
https://doi.org/10.1038/s41598-017-13987-9
Autor:
Maria Rocasalbas, Alba Vidal-Torres, Rafael Maldonado, José Miguel Vela, Helmut Buschmann, José M. Baeyens, S.A. Bura, Xavier Codony, Daniel Zamanillo, Manuel Merlos, Luz Romero, Beatriz de la Puente, Clara Touriño, Begoña Fernández-Pastor
Publikováno v:
European Journal of Pharmacology. 711:63-72
While opioids are potent analgesics widely used in the management of pain, a number of well-known adverse effects limit their use. The sigma-1 receptor is a ligand-regulated molecular chaperone involved in pain processing, including modulation of opi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea3569efd18364bbb1b51eccb07e186e
https://doi.org/10.1016/j.ejphar.2013.04.018
https://doi.org/10.1016/j.ejphar.2013.04.018