Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Beatriz Tucker"'
Autor:
Sofia Christakoudi, Manohursingh Runglall, Paula Mobillo, Tjir-Li Tsui, Claire Duff, Clara Domingo-Vila, Yogesh Kamra, Florence Delaney, Rosa Montero, Anastasia Spiridou, Theodoros Kassimatis, Sui Phin-Kon, Beatriz Tucker, Christopher Farmer, Terry B. Strom, Graham M. Lord, Irene Rebollo-Mesa, Daniel Stahl, Steven Sacks, Maria P. Hernandez-Fuentes, Paramit Chowdhury
Publikováno v:
EBioMedicine, Vol 41, Iss , Pp 571-583 (2019)
Background: Acute T-cell mediated rejection (TCMR) is usually indicated by alteration in serum-creatinine measurements when considerable transplant damage has already occurred. There is, therefore, a need for non-invasive early detection of immune si
Externí odkaz:
https://doaj.org/article/dbd47bb0ad88471a9010ab59f2dad071
Autor:
Sofia Christakoudi, Manohursingh Runglall, Paula Mobillo, Irene Rebollo-Mesa, Tjir-Li Tsui, Estefania Nova-Lamperti, Catharine Taube, Sonia Norris, Yogesh Kamra, Rachel Hilton, Titus Augustine, Sunil Bhandari, Richard Baker, David Berglund, Sue Carr, David Game, Sian Griffin, Philip A. Kalra, Robert Lewis, Patrick B. Mark, Stephen D. Marks, Iain MacPhee, William McKane, Markus G. Mohaupt, Estela Paz-Artal, Sui Phin Kon, Daniel Serón, Manish D. Sinha, Beatriz Tucker, Ondrej Viklický, Daniel Stahl, Robert I. Lechler, Graham M. Lord, Maria P. Hernandez-Fuentes
Publikováno v:
EBioMedicine, Vol 58, Iss , Pp 102899- (2020)
Background: Kidney transplant recipients (KTRs) with “operational tolerance” (OT) maintain a functioning graft without immunosuppressive (IS) drugs, thus avoiding treatment complications. Nevertheless, IS drugs can influence gene-expression signa
Externí odkaz:
https://doaj.org/article/3e888ca856124c02877325b343eab615
Autor:
Gowri Gopalakrishna, Miranda Langendam, Rob Scholten, Patrick Bossuyt, Mariska Leeflang, Anna Noel-Storr, James Thomas, Iain Marshall, Byron Wallace, Penny Whiting, Clare Davenport, Gowri GopalaKrishna, Isabel de Salis, Sue Mallett, Robert Wolff, Richard Riley, Marie Westwood, Jos Kleinen, Gary Collins, Hans Reitsma, Karel Moons, Antonia Zapf, Annika Hoyer, Katharina Kramer, Oliver Kuss, J. Ensor, J. J. Deeks, E. C. Martin, R. D. Riley, Gerta Rücker, Susanne Steinhauser, Martin Schumacher, Joie Ensor, Kym Snell, Brian Willis, Thomas Debray, Jon Deeks, Lavinia Ferrante di Ruffano, Sian Taylor-Phillips, Chris Hyde, Stuart A. Taylor, Gauraang Batnagar, STREAMLINE COLON Investigators, STREAMLINE LUNG Investigators, METRIC Investigators, Lavinia Ferrante Di Ruffano, Farah Seedat, Aileen Clarke, Sarah Byron, Frances Nixon, Rebecca Albrow, Thomas Walker, Carla Deakin, Zhivko Zhelev, Harriet Hunt, Yaling Yang, Lucy Abel, James Buchanan, Thomas Fanshawe, Bethany Shinkins, Laure Wynants, Jan Verbakel, Sabine Van Huffel, Dirk Timmerman, Ben Van Calster, Aeliko Zwinderman, Jason Oke, Jack O’Sullivan, Rafael Perera, Brian Nicholson, Hannah L. Bromley, Tracy E. Roberts, Adele Francis, Denniis Petrie, G. Bruce Mann, Kinga Malottki, Holly Smith, Lucinda Billingham, Alice Sitch, Oke Gerke, Mie Holm-Vilstrup, Eivind Antonsen Segtnan, Ulrich Halekoh, Poul Flemming Høilund-Carlsen, Bernard G. Francq, Jac Dinnes, Julie Parkes, Walter Gregory, Jenny Hewison, Doug Altman, William Rosenberg, Peter Selby, Julien Asselineau, Paul Perez, Aïssatou Paye, Emilie Bessede, Cécile Proust-Lima, Christiana Naaktgeboren, Joris de Groot, Anne Rutjes, Johannes Reitsma, Emmanuel Ogundimu, Jonathan Cook, Yannick Le Manach, Yvonne Vergouwe, Romin Pajouheshnia, Rolf Groenwold, Karen Moons, Linda Peelen, Daan Nieboer, Bavo De Cock, Micael J. Pencina, Ewout W. Steyerberg, Jennifer Cooper, Nick Parsons, Chris Stinton, Steve Smith, Andy Dickens, Rachel Jordan, Alexandra Enocson, David Fitzmaurice, Peymane Adab, Charles Boachie, Gaj Vidmar, Karoline Freeman, Martin Connock, Rachel Court, Carl Moons, Jessica Harris, Andrew Mumford, Zoe Plummer, Kurtis Lee, Barnaby Reeves, Chris Rogers, Veerle Verheyden, Gianni D. Angelini, Gavin J. Murphy, Jeremy Huddy, Melody Ni, Katherine Good, Graham Cooke, George Hanna, Jie Ma, K. G. M. (Carl) Moons, Joris A. H. de Groot, Doug G. Altman, Johannes B. Reitsma, Gary S. Collins, Karel G. M. Moons, Douglas G. Altman, Adina Najwa Kamarudin, Ruwanthi Kolamunnage-Dona, Trevor Cox, Simone Borsci, Teresa Pérez, M.Carmen Pardo, Angel Candela-Toha, Alfonso Muriel, Javier Zamora, Sabina Sanghera, Syed Mohiuddin, Richard Martin, Jenny Donovan, Joanna Coast, Mikyung Kelly Seo, John Cairns, Elizabeth Mitchell, Alison Smith, Judy Wright, Peter Hall, Michael Messenger, Nicola Calder, Nyantara Wickramasekera, Karen Vinall-Collier, Andrew Lewington, Johanna Damen, David Cairns, Michelle Hutchinson, Cathie Sturgeon, Liz Mitchel, Rebecca Kift, Sofia Christakoudi, Manohursingh Rungall, Paula Mobillo, Rosa Montero, Tjir-Li Tsui, Sui Phin Kon, Beatriz Tucker, Steven Sacks, Chris Farmer, Terry Strom, Paramit Chowdhury, Irene Rebollo-Mesa, Maria Hernandez-Fuentes, Johanna A. A. G. Damen, Thomas P. A. Debray, Pauline Heus, Lotty Hooft, Rob J. P. M. Scholten, Ewoud Schuit, Ioanna Tzoulaki, Camille M. Lassale, George C. M. Siontis, Virginia Chiocchia, Corran Roberts, Michael Maia Schlüssel, Stephen Gerry, James A. Black, Yvonne T. van der Schouw, Linda M. Peelen, Graeme Spence, David McCartney, Ann van den Bruel, Daniel Lasserson, Gail Hayward, Werner Vach, Antoinette de Jong, Coreline Burggraaff, Otto Hoekstra, Josée Zijlstra, Henrica de Vet, Sara Graziadio, Joy Allen, Louise Johnston, Rachel O’Leary, Michael Power, Louise Johnson, Ray Waters, John Simpson, Thomas R. Fanshawe, Peter Phillips, Andrew Plumb, Emma Helbren, Steve Halligan, Alastair Gale, Peggy Sekula, Willi Sauerbrei, Julia R. Forman, Susan J. Dutton, Yemisi Takwoingi, Elizabeth M. Hensor, Thomas E. Nichols, Emmanuelle Kempf, Raphael Porcher, Jennifer de Beyer, Douglas Altman, Sally Hopewell, John Dennis, Beverley Shields, Angus Jones, William Henley, Ewan Pearson, Andrew Hattersley, on behalf of the MASTERMIND consortium, Fueloep Scheibler, Anne Rummer, Sibylle Sturtz, Robert Großelfinger, Katie Banister, Craig Ramsay, Augusto Azuara-Blanco, Jennifer Burr, Manjula Kumarasamy, Rupert Bourne, Ijeoma Uchegbu, Jennifer Murphy, Alex Carter, Jen Murphy, Joachim Marti, Julie Eatock, Julie Robotham, Maria Dudareva, Mark Gilchrist, Alison Holmes, Phillip Monaghan, Sarah Lord, Andrew StJohn, Sverre Sandberg, Christa Cobbaert, Lieselotte Lennartz, Wilma Verhagen-Kamerbeek, Christoph Ebert, Andrea Horvath, for the Test Evaluation Working Group of the European Federation of Clinical Chemistry and Laboratory Medicine, Kevin Jenniskens, Jaime Peters, Bogdan Grigore, Obi Ukoumunne, Brooke Levis, Andrea Benedetti, Alexander W. Levis, John P. A. Ioannidis, Ian Shrier, Pim Cuijpers, Simon Gilbody, Lorie A. Kloda, Dean McMillan, Scott B Patten, Russell J. Steele, Roy C Ziegelstein, Charles H. Bombardier, Flavia de Lima Osório, Jesse R. Fann, Dwenda Gjerdingen, Femke Lamers, Manote Lotrakul, Sonia R Loureiro, Bernd Löwe, Juwita Shaaban, Lesley Stafford, Henk C. P. M. van Weert, Mary A. Whooley, Linda S. Williams, Karin A. Wittkampf, Albert S. Yeung, Brett D. Thombs, Chris Cooper, Tom Nieto, Claire Smith, Olga Tucker, Janine Dretzke, Andrew Beggs, Nirmala Rai, Sue Bayliss, Simon Stevens, Sue Mallet, Sudha Sundar, Emma Hall, Nuria Porta, David Lorente Estelles, Johann de Bono, on behalf of the CTC-STOP protocol development group
Publikováno v:
Diagnostic and Prognostic Research, Vol 1, Iss 1, Pp 1-5 (2017)
Externí odkaz:
https://doaj.org/article/6e4d4aeef31d4a4ab5f1974912d6fe8c
Autor:
Steven H. Sacks, Clara Domingo-Vila, Terry B. Strom, Florence Delaney, Claire Duff, Manohursingh Runglall, Paula Mobillo, Tjir Li Tsui, Rosa Montero, Sui Phin-Kon, Maria P. Hernandez-Fuentes, Yogesh Kamra, Anastasia Spiridou, Paramit Chowdhury, Graham M. Lord, Irene Rebollo-Mesa, Sofia Christakoudi, Daniel Stahl, Theodoros Kassimatis, Christopher K.T. Farmer, Beatriz Tucker
Publikováno v:
EBioMedicine
EBioMedicine, Vol 41, Iss, Pp 571-583 (2019)
Christakoudi, S, Runglall, M, Mobillo, P, Tsui, T L, Duff, C, Domingo-Vila, C, Kamra, Y, Delaney, F, Montero, R, Spiridou, A, Kassimatis, T, Phin-Kon, S, Tucker, B, Farmer, C, Strom, T B, Lord, G M, Rebollo-Mesa, I, Stahl, D, Sacks, S, Hernandez-Fuentes, M P & Chowdhury, P 2019, ' Development of a multivariable gene-expression signature targeting T-cell-mediated rejection in peripheral blood of kidney transplant recipients validated in cross-sectional and longitudinal samples ', EBioMedicine, vol. 41, pp. 571-583 . https://doi.org/10.1016/j.ebiom.2019.01.060
Christakoudi, S, Runglall, M, Mobillo, P A, Tsui, T-L, Duff, C, Domingo Vila, C, Kamra, Y K, Delaney, F, Montero, R, Spiridou, A, Kassimatis, T, Phin Kon, S, Tucker, B, Farmer, C, Strom, T B, Lord, G M, Rebollo-Mesa, I, Stahl, D, Sacks, S, Hernandez-Fuentes, M P & Chowdhury, P 2019, ' Development of a multivariable geneexpression signature targeting T-cell-mediated rejection in peripheral blood of kidney transplant recipients validated in crosssectional and longitudinal samples ', EBioMedicine, vol. 41, no. 0, pp. 571-583 . https://doi.org/10.1016/j.ebiom.2019.01.060
EBioMedicine, Vol 41, Iss, Pp 571-583 (2019)
Christakoudi, S, Runglall, M, Mobillo, P, Tsui, T L, Duff, C, Domingo-Vila, C, Kamra, Y, Delaney, F, Montero, R, Spiridou, A, Kassimatis, T, Phin-Kon, S, Tucker, B, Farmer, C, Strom, T B, Lord, G M, Rebollo-Mesa, I, Stahl, D, Sacks, S, Hernandez-Fuentes, M P & Chowdhury, P 2019, ' Development of a multivariable gene-expression signature targeting T-cell-mediated rejection in peripheral blood of kidney transplant recipients validated in cross-sectional and longitudinal samples ', EBioMedicine, vol. 41, pp. 571-583 . https://doi.org/10.1016/j.ebiom.2019.01.060
Christakoudi, S, Runglall, M, Mobillo, P A, Tsui, T-L, Duff, C, Domingo Vila, C, Kamra, Y K, Delaney, F, Montero, R, Spiridou, A, Kassimatis, T, Phin Kon, S, Tucker, B, Farmer, C, Strom, T B, Lord, G M, Rebollo-Mesa, I, Stahl, D, Sacks, S, Hernandez-Fuentes, M P & Chowdhury, P 2019, ' Development of a multivariable geneexpression signature targeting T-cell-mediated rejection in peripheral blood of kidney transplant recipients validated in crosssectional and longitudinal samples ', EBioMedicine, vol. 41, no. 0, pp. 571-583 . https://doi.org/10.1016/j.ebiom.2019.01.060
Background Acute T-cell mediated rejection (TCMR) is usually indicated by alteration in serum-creatinine measurements when considerable transplant damage has already occurred. There is, therefore, a need for non-invasive early detection of immune sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae24299bfbd3674285318dfe252d4a2a
http://europepmc.org/articles/PMC6441872
http://europepmc.org/articles/PMC6441872
Autor:
Iain MacPhee, Catharine Taube, Beatriz Tucker, Manohursingh Runglall, David Game, Daniel Serón, Yogesh Kamra, Daniel Stahl, Sian Griffin, Philip A. Kalra, Sui Phin Kon, Markus G. Mohaupt, Paula Mobillo, William McKane, Rachel Hilton, Estefania Nova-Lamperti, Robert Lewis, Titus Augustine, Graham M. Lord, Tjir Li Tsui, Ondrej Viklický, Irene Rebollo-Mesa, Sofia Christakoudi, Manish D. Sinha, Patrick B. Mark, Maria P. Hernandez-Fuentes, Stephen D. Marks, Sunil Bhandari, Sue Carr, David Berglund, Robert I. Lechler, S. Norris, Estela Paz-Artal, Richard Baker
Publikováno v:
Christakoudi, S, Runglall, M, Mobillo, P, Rebollo-Mesa, I, Tsui, T L, Nova-Lamperti, E, Taube, C, Norris, S, Kamra, Y, Hilton, R, Augustine, T, Bhandari, S, Baker, R, Berglund, D, Carr, S, Game, D, Griffin, S, Kalra, P A, Lewis, R, Mark, P B, Marks, S D, MacPhee, I, McKane, W, Mohaupt, M G, Paz-Artal, E, Kon, S P, Serón, D, Sinha, M D, Tucker, B, Viklický, O, Stahl, D, Lechler, R I, Lord, G M & Hernandez-Fuentes, M P 2020, ' Development and validation of the first consensus gene-expression signature of operational tolerance in kidney transplantation, incorporating adjustment for immunosuppressive drug therapy ', EBioMedicine, vol. 58, 102899 . https://doi.org/10.1016/j.ebiom.2020.102899
EBioMedicine, Vol 58, Iss, Pp 102899-(2020)
Christakoudi, S, Runglall, M, Mobillo, P, Rebollo-Mesa, I, Tjir-Li, T, Viklický, O, Stahl, D, Lechler, R, Lord, G & Hernandez Fuentes, M 2020, ' Development and validation of the first consensus gene-expression signature of operational tolerance in kidney transplantation, incorporating adjustment for immunosuppressive drug therapy ', EBioMedicine, vol. 58, 102899 . https://doi.org/10.1016/j.ebiom.2020.102899
EBioMedicine
EBioMedicine, Vol 58, Iss, Pp 102899-(2020)
Christakoudi, S, Runglall, M, Mobillo, P, Rebollo-Mesa, I, Tjir-Li, T, Viklický, O, Stahl, D, Lechler, R, Lord, G & Hernandez Fuentes, M 2020, ' Development and validation of the first consensus gene-expression signature of operational tolerance in kidney transplantation, incorporating adjustment for immunosuppressive drug therapy ', EBioMedicine, vol. 58, 102899 . https://doi.org/10.1016/j.ebiom.2020.102899
EBioMedicine
Background: Kidney transplant recipients (KTRs) with “operational tolerance” (OT) maintain a functioning graft without immunosuppressive (IS) drugs, thus avoiding treatment complications. Nevertheless, IS drugs can influence gene-expression signa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4df733baf3a0af783e2d969fa5ffd42
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-421318
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-421318
Autor:
Robert Lewis, Rachel Hilton, Estefania Nova-Lamperti, Richard Baker, Daniel Stahl, Sue Carr, David Berglund, Tjir Li Tsui, Iain MacPhee, Irene Rebollo-Mesa, Sofia Christakoudi, Robert I. Lechler, Manish D. Sinha, Graham M. Lord, Sui Phin Kon, Maria P. Hernandez-Fuentes, Manohursingh Runglall, Beatriz Tucker, S. Norris, Paula Mobillo, Markus G. Mohaupt, Sian Griffin, Philip A. Kalra, Sunil Bhandari, Yogesh Kamra, Patrick B. Mark, David Game, Stephen D. Marks, William McKane, Daniel Serón, Ravi Pararajasingam, Ondrej Viklický
Publikováno v:
BASE-Bielefeld Academic Search Engine
Steroid conversion (HSD11B1, HSD11B2, H6PD) and receptor genes (NR3C1, NR3C2) were examined in kidney-transplant recipients with "operational tolerance" and chronic rejection (CR), independently and within the context of 88 tolerance-associated genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9350fcb1d0ad0c84f106c01e09018898
http://hdl.handle.net/10044/1/57247
http://hdl.handle.net/10044/1/57247
Autor:
Sui Phin-Kon, Tjir-Li Tsui, Paramit Chowdhury, Anastasia Spiridou, Florence Delaney, Terry B. Strom, Manohursingh Runglall, Graham M. Lord, Beatriz Tucker, Yogesh Karma, Paula Mobillo, Rosa Montero, Daniel Stahl, Christopher K.T. Farmer, Maria P. Hernandez-Fuentes, Steven H. Sacks, Irene Rebollo-Mesa, Sofia Christakoudi
Publikováno v:
Transplantation. 102:S180
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b8d48488162a1be827b5b56c71d7ee0
https://doi.org/10.1097/01.tp.0000542822.75680.9c
https://doi.org/10.1097/01.tp.0000542822.75680.9c
Autor:
Roscoe M. Moore, Marinus H. de Keijzer, Alison MacLeod, Chris E. Kaufman, Shigeaki Muto, Hikaru Koide, A. Oliet, Giorgio Annessi, R. Romero, M. Segasothy, Ronald G. Kaczmarek, P. Ronco, A. Notarbartolo, Sali Caglar, C.M. Barbagallo, Paola Omedè, William E. Nelson, Egidio Lusvarghi, Julie Piper, E. Barrio, Mayer Brezis, Iren B. Kovacs, L. Campanacci, Osman Özcebe, Stanford Hamburger, Gianna Mazzucco, Angela Recker, Shuichi Ishii, Tohru Yamaji, F. Mignon, C. Michel, J.L. Mahe, Neva E. Haites, M.A. Morel, Francesco Paolo Schena, Geoffrey M. Berlyne, Gobi Engler-Blum, J. Cledes, Eduardo H. Garin, Massimo Massaia, Teut Risler, Renate Klauser, J. Forteza, Ko Okumura, Cetin Turgan, Serafettin Kirazli, Giovanna Zambruno, S.R. Stella, Anthony E.G. Raine, Oktay Özdemir, Carlo Feletti, Antonio Amoroso, John Simpson, Kurt Widhalm, M. Bardelli, Freek J. Zijlstra, Monika Pergande, J.C. Bigot, Cristiana Rollino, Samuel N. Heyman, Yasushi Asano, Laurence R.I. Baker, S. Tomé Martínez de Rituerto, Anne Dieny, Beatriz Tucker, E. Vijaykumar, P.H. Ong, Semra Dündar, P. Dosquet, Dario Roccatell, Giuseppe Aimo, Stanley A. McMillan, Giuseppe Piccoli, Nicole Pinel, E. Hernández, Yoshihisa Itoh, J. Goffinet, Tadashi Kawai, Jean-Marc Weinstein, Erich Pohanka, Reinhold Deppisch, Vincenzo Montinaro, Claudia A. Müller, Teruyo Ozaki, Leopoldo Baldrati, A. Baraldi, M.I. Rodriguez, Martina Franz, Gerhard A. Müller, Mark Gruber, Claudia Capponcini, Nick Corontzes, Alan N. Charney, F. Fischetti, L. Furci, R. Carretta, M C Jones, Adalbert Bohle, Klaus Jung, O. Traindl, Josef Kovarik, V.E.R. Melhado, Peggy Hamilton, F. Vran, David A. Power, Fujiro Sendo, A. Vigil, Turgay Arinsoy, Rosanna Coppo, Bruno Watschinger, William Dickey, M.Y. Norazlina, Silvano Battaglio, V. Scafidi, Kyuzi Kamoi, Ryuta Okutani, Jean-Charles Renversez, Helmut Reichel, Daniel Cordonnier, Miyuki Ishibashi, L.G. Bardou, B. Mougenot, Wolfgang Kühn, C. Versolato, Hans Pidlich, Abraham P. Provoost, M. Jamil, S. Raziuddin, D. Sanchez-Guisande, A. Vasile, Ünal Yasavul, Prabir Roy-Chaudhury, A. Galione, Yasuhiko Tomino, Susan Reading, L.A. Moura, P. Gallar, Yutaka Yaguchi, Eberhard Ritz, Gina Mazzola, Kenneth G. Porter, M.-A. Bernard, Simon D. Roger, E.N. Wardle, Dino Docci, M.A. Boim, M.R. Averna, B. Viron, Thomas Kahn, N. Schor, S. Muiesan, Loreto Gesualdo, Elke Stier, D. Novoa, B. Fabris, Elisabetta Rubbiani, Jasmina Markovic-Lipkovski, François Le Marc’hadour, Claire M. Hill, Nurol Arik, Mario Boccadoro
Publikováno v:
Nephron. 62:I-VI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7419d3c4214572d490760991f9908e1
https://doi.org/10.1159/000187083
https://doi.org/10.1159/000187083
Autor:
Maria P. Hernandez-Fuentes, Paula Mobillo, Graham M. Lord, Christopher K.T. Farmer, Phin S. Kon, Paramit Chowdhury, Beatriz Tucker, Manohursingh Runglall, Terry B. Strom, Steven H. Sacks, Irene Rebollo-Mesa
Publikováno v:
Transplantation. 98:878
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a22621a22442442fa10dc78db37862ed
https://doi.org/10.1097/00007890-201407151-02998
https://doi.org/10.1097/00007890-201407151-02998
Autor:
Maria P. Hernandez-Fuentes, Paramit Chowdhury, Graham M. Lord, S. Norris, Manohursingh Runglall, Terry B. Strom, Irene Rebollo-Mesa, S. P. Kon, Beatriz Tucker, Paula Mobillo, Christopher K.T. Farmer, Steven H. Sacks
Publikováno v:
Transplantation Journal. 94:1179
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb82b322fc41385d3ae6a6f8ef9a84aa
https://doi.org/10.1097/00007890-201211271-02342
https://doi.org/10.1097/00007890-201211271-02342