Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Beatriz Trenor"'
Autor:
Jorge Sánchez, Giorgio Luongo, Mark Nothstein, Laura A. Unger, Javier Saiz, Beatriz Trenor, Armin Luik, Olaf Dössel, Axel Loewe
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
In patients with atrial fibrillation, intracardiac electrogram signal amplitude is known to decrease with increased structural tissue remodeling, referred to as fibrosis. In addition to the isolation of the pulmonary veins, fibrotic sites are conside
Externí odkaz:
https://doaj.org/article/99c546cae19544c9aa77a92af5a4e010
Autor:
Jordi Cano, Esther Zorio, Andrea Mazzanti, Miguel Ángel Arnau, Beatriz Trenor, Silvia G. Priori, Javier Saiz, Lucia Romero
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
The prolongation of the QT interval represents the main feature of the long QT syndrome (LQTS), a life-threatening genetic disease. The heterozygous SCN5A V411M mutation of the human sodium channel leads to a LQTS type 3 with severe proarrhythmic eff
Externí odkaz:
https://doaj.org/article/ff65d0b4f8104354aaf734f3cddc1cf8
Publikováno v:
Cells, Vol 10, Iss 11, p 2852 (2021)
During atrial fibrillation, cardiac tissue undergoes different remodeling processes at different scales from the molecular level to the tissue level. One central player that contributes to both electrical and structural remodeling is the myofibroblas
Externí odkaz:
https://doaj.org/article/d73a5e4b2b0a43fc80a225f28565ace0
Autor:
Jorge Sánchez, Juan F. Gomez, Laura Martinez-Mateu, Lucia Romero, Javier Saiz, Beatriz Trenor
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Background: Atrial fibrillation (AF), the most common cardiac arrhythmia, is characterized by alteration of the action potential (AP) propagation. Under persistent AF, myocytes undergo electrophysiological and structural remodeling, which involves fi
Externí odkaz:
https://doaj.org/article/1aa82db15e5a46859bc40845ce4d0da3
Autor:
Edison F. Carpio, Juan F. Gomez, Rafael Sebastian, Alejandro Lopez-Perez, Eduardo Castellanos, Jesus Almendral, Jose M. Ferrero, Beatriz Trenor
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Patients suffering from heart failure and left bundle branch block show electrical ventricular dyssynchrony causing an abnormal blood pumping. Cardiac resynchronization therapy (CRT) is recommended for these patients. Patients with positive therapy r
Externí odkaz:
https://doaj.org/article/55aec4b29851441790eecdcf661ff91a
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0217993 (2019)
BackgroundHeart failure (HF) is characterized, among other factors, by a progressive loss of contractile function and by the formation of an arrhythmogenic substrate, both aspects partially related to intracellular Ca2+ cycling disorders. In failing
Externí odkaz:
https://doaj.org/article/5afef8d64cf147aea55c12fba4d22975
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Heart failure (HF) is characterized by altered Ca2+ cycling, resulting in cardiac contractile dysfunction. Failing myocytes undergo electrophysiological remodeling, which is known to be the main cause of abnormal Ca2+ homeostasis. However, structural
Externí odkaz:
https://doaj.org/article/1a78826037b44689b393f03de553b322
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187739 (2017)
Abnormal intracellular Ca2+ handling is the major contributor to the depressed cardiac contractility observed in heart failure. The electrophysiological remodeling associated with this pathology alters both the action potential and the Ca2+ dynamics,
Externí odkaz:
https://doaj.org/article/f875c42acda34139bc90bc7b2adf9935
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0167060 (2016)
The slowly inactivating or late Na+ current, INa-L, can contribute to the initiation of both atrial and ventricular rhythm disturbances in the human heart. However, the cellular and molecular mechanisms that underlie these pro-arrhythmic influences a
Externí odkaz:
https://doaj.org/article/a45c83278c76462ba283223c26081a7a
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e103273 (2014)
Heart failure is operationally defined as the inability of the heart to maintain blood flow to meet the needs of the body and it is the final common pathway of various cardiac pathologies. Electrophysiological remodeling, intercellular uncoupling and
Externí odkaz:
https://doaj.org/article/0a3697143a3b4919b0010be269ca478c