Neuroprotective role of nitric oxide inhalation and nitrite in a Neonatal Rat Model of Hypoxic-Ischemic Injury

Autor: Peter Jung, Euntaik Ha, Meijuan Zhang, Carolyn Fall, Mindy Hwang, Emily Taylor, Samuel Stetkevich, Aditi Bhanot, Christopher G. Wilson, Johnny D. Figueroa, Andre Obenaus, Shannon Bragg, Beatriz Tone, Saburi Eliamani, Barbara Holshouser, Arlin B. Blood, Taiming Liu

Publikováno v: PLoS ONE, Vol 17, Iss 5 (2022)

Background There is evidence from various models of hypoxic-ischemic injury (HII) that nitric oxide (NO) is protective. We hypothesized that either inhaled NO (iNO) or nitrite would alleviate brain injury in neonatal HII via modulation of mitochondri

Externí odkaz: https://doaj.org/article/a9539be2e9814a93bafbf003e0d5f3d9

Neuroprotective role of nitric oxide inhalation and nitrite in a Neonatal Rat Model of Hypoxic-Ischemic Injury

Autor: Peter Jung, Euntaik Ha, Meijuan Zhang, Carolyn Fall, Mindy Hwang, Emily Taylor, Samuel Stetkevich, Aditi Bhanot, Christopher G. Wilson, Johnny D. Figueroa, Andre Obenaus, Shannon Bragg, Beatriz Tone, Saburi Eliamani, Barbara Holshouser, Arlin B. Blood, Taiming Liu

Publikováno v: PloS one, vol 17, iss 5

Background There is evidence from various models of hypoxic-ischemic injury (HII) that nitric oxide (NO) is protective. We hypothesized that either inhaled NO (iNO) or nitrite would alleviate brain injury in neonatal HII via modulation of mitochondri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57200d2240c0d8200846b61c517a5a7c
https://pubmed.ncbi.nlm.nih.gov/35544542

A Biomarker for Predicting Responsiveness to Stem Cell Therapy Based on Mechanism-of-Action: Evidence from Cerebral Injury

Autor: Dustin R. Wakeman, Nirmalya Ghosh, Amy Plaia, Nejmi Dilmac, Walter D. Niles, Richard E. Hartman, Ruslan Nuryyev, Evan Y. Snyder, Neal H. Nathan, Melissa S. Dulcich, Alena Yusof, Richard L. Sidman, Beatriz Tone, Stephen Ashwal, Janessa B Law, Cameron D. Pernia, Andre Obenaus

Publikováno v: Cell Reports. 31:107622

To date, no stem cell therapy has been directed to specific recipients-and, conversely, withheld from others-based on a clinical or molecular profile congruent with that cell's therapeutic mechanism-of-action (MOA) for that condition. We address this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64c96e8583aa13ce26014189dafe35a5
https://doi.org/10.1016/j.celrep.2020.107622

Long-term magnetic resonance imaging of stem cells in neonatal ischemic injury

Autor: Evan Y. Snyder, Stephen Ashwal, Murat Digicaylioglu, Hou Rou Tian, Nejmi Dilmac, Richard E. Hartman, Beatriz Tone, Andre Obenaus

Publikováno v: Annals of Neurology. 69:282-291

Objective: Quantitative magnetic resonance imaging (MRI) can serially and noninvasively assess the degree of injury in rat pup models of hypoxic ischemic injury (HII). It can also noninvasively monitor stem cell migration following iron oxide prelabe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4592e769da190243efe55e7b5eb3196
https://doi.org/10.1002/ana.22168

Hypothermia Modulates Cytokine Responses After Neonatal Rat Hypoxic-Ischemic Injury and Reduces Brain Damage

Autor: Nirmalya Ghosh, Beatriz Tone, Brian McFadden, Denise L. Bellinger, Xiangpeng Yuan, Stephen Ashwal, Andre Obenaus

Publikováno v: ASN Neuro, Vol 6 (2014)
Yuan, X; Ghosh, N; McFadden, B; Tone, B; Bellinger, DL; Obenaus, A; et al.(2015). Hypothermia modulates cytokine responses after neonatal rat hypoxic-ischemic injury and reduces brain damage. ASN Neuro, 6(6). doi: 10.1177/1759091414558418. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/3tp7q6w0
ASN NEURO

While hypothermia (HT) is the standard-of-care for neonates with hypoxic ischemic injury (HII), the mechanisms underlying its neuroprotective effect are poorly understood. We examined ischemic core/penumbra and cytokine/chemokine evolution in a 10-da

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d0aabc1139e170d25428f36a2af568
https://doaj.org/article/b84aac681eaf4c439b3d5ab8f26b97ed