Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Beatriz Suarez-Alvarez"'
Autor:
Maria Laura Saiz, Laura Lozano-Chamizo, Aida Bernardo Florez, Marzia Marciello, Paula Diaz-Bulnes, Viviana Corte-Iglesias, Cristian Ruiz Bernet, Raul R. Rodrigues-Diez, Cristina Martin-Martin, Mar Rodriguez-Santamaria, Ivan Fernandez-Vega, Ramon M. Rodriguez, Carmen Diaz-Corte, Beatriz Suarez-Alvarez, Marco Filice, Carlos Lopez-Larrea
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 174, Iss , Pp 116492- (2024)
Targeting epigenetic mechanisms has emerged as a potential therapeutic approach for the treatment of kidney diseases. Specifically, inhibiting the bromodomain and extra-terminal (BET) domain proteins using the small molecule inhibitor JQ1 has shown p
Externí odkaz:
https://doaj.org/article/faef2a249ec44921b88449981de7a8ea
Autor:
Sandra Rayego-Mateos, Pamela Basantes, José Luis Morgado-Pascual, Beatriz Brazal Prieto, Beatriz Suarez-Alvarez, Alberto Ortiz, Carlos Lopez-Larrea, Marta Ruiz-Ortega
Publikováno v:
Antioxidants, Vol 12, Iss 5, p 1130 (2023)
Among the mechanisms involved in the progression of kidney disease, mitochondrial dysfunction has special relevance. Epigenetic drugs such as inhibitors of extra-terminal domain proteins (iBET) have shown beneficial effects in experimental kidney dis
Externí odkaz:
https://doaj.org/article/da9ed6c631bd4d0fb30bdba55b41da22
Autor:
Estefanía Salgado Del Riego, María Laura Saiz, Viviana Corte-Iglesias, Blanca Leoz Gordillo, Cristina Martin-Martin, Mercedes Rodríguez-Pérez, Dolores Escudero, Carlos Lopez-Larrea, Beatriz Suarez-Alvarez
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The cellular immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in response to full mRNA COVID-19 vaccination could be variable among healthy individuals. Studies based only in specific antibody levels could show an erron
Externí odkaz:
https://doaj.org/article/354e270f3f57448ba0323a50fbfe4bd5
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/2f9b9fe11004452facfac558bea04231
Autor:
Lucas Opazo-Ríos, Antonio Tejera-Muñoz, Manuel Soto Catalan, Vanessa Marchant, Carolina Lavoz, Sebastián Mas Fontao, Juan Antonio Moreno, Marta Fierro Fernandez, Ricardo Ramos, Beatriz Suarez-Alvarez, Carlos López-Larrea, Marta Ruiz-Ortega, Jesús Egido, Raúl R. Rodrigues-Díez
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Diabetic nephropathy (DN) is the main leading cause of chronic kidney disease worldwide. Although remarkable therapeutic advances have been made during the last few years, there still exists a high residual risk of disease progression to end-stage re
Externí odkaz:
https://doaj.org/article/1da83a47d26d4589802051a891591700
Type IV Collagen and SOX9 Are Molecular Targets of BET Inhibition in Experimental Glomerulosclerosis
Autor:
José Luis Morgado-Pascual, Beatriz Suarez-Alvarez, Vanessa Marchant, Pamela Basantes, Pierre-Louis Tharaux, Alberto Ortiz, Carlos Lopez-Larrea, Marta Ruiz-Ortega, Sandra Rayego-Mateos
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 486 (2022)
Progressive glomerulonephritis (GN) is characterized by an excessive accumulation of extracellular (ECM) proteins, mainly type IV collagen (COLIV), in the glomerulus leading to glomerulosclerosis. The current therapeutic approach to GN is suboptimal.
Externí odkaz:
https://doaj.org/article/26ed519969b4442cadadd778756d9736
Autor:
Paula Diaz-Bulnes, Maria Laura Saiz, Viviana Corte-Iglesias, Raúl R Rodrigues-Diez, Aida Bernardo Florez, Cristian Ruiz Bernet, Cristina Martin Martin, Marta Ruiz-Ortega, Beatriz Suarez-Alvarez, Carlos López-Larrea
Publikováno v:
Antioxidants, Vol 11, Iss 7, p 1355 (2022)
Loss of protein homeostasis (proteostasis) in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR), restoring correct protein folding. Sustained ER stress exacerbates activation of the major UPR branches (IRE1α/XBP1, PERK/ATF
Externí odkaz:
https://doaj.org/article/607d22f0cf2b41fcb61e583db649dfcd
Autor:
Aroa Baragaño Raneros, Ramon M Rodriguez, Aida Bernardo Flórez, Pilar Palomo, Enrique Colado, Alfredo Minguela, Beatriz Suarez-Alvarez, Carlos López-Larrea
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
B7-H6, a ligand for the NK activating receptor NKp30, has been identified as a biomarker of poor prognosis in several solid cancers. However, little is known about the role of B7-H6 and the mechanisms that control its expression in acute myeloid leuk
Externí odkaz:
https://doaj.org/article/1416c9e5a0784184977ba8cf9ef8ba0d
Autor:
Lucia Tejedor-Santamaria, Jose Luis Morgado-Pascual, Laura Marquez-Exposito, Beatriz Suarez-Alvarez, Raul R. Rodrigues-Diez, Antonio Tejera-Muñoz, Vanessa Marchant, Sergio Mezzano, Carlos Lopez-Larrea, Anna Sola, Gema Maria Fernandez-Juarez, Alberto Ortiz, Sandra Rayego-Mateos, Marta Ruiz-Ortega
Publikováno v:
Pharmaceuticals, Vol 15, Iss 2, p 121 (2022)
Crescentic glomerulonephritis is a devastating autoimmune disease that without early and properly treatment may rapidly progress to end-stage renal disease and death. Current immunosuppressive treatment provides limited efficacy and an important burd
Externí odkaz:
https://doaj.org/article/5f033fe79f654d77a5d276372d885471
Publikováno v:
Biomedicines, Vol 9, Iss 11, p 1614 (2021)
Aberrant NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome activation in innate immune cells, triggered by diverse cellular danger signals, leads to the production of inflammatory cytokines (IL-1β and IL-18) and cell death by py
Externí odkaz:
https://doaj.org/article/b393e03cce004486bd1a1371d6c2716b