Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Beatriz Sánchez-Solana"'
Autor:
María-Milagros Rodríguez-Cano, María-Julia González-Gómez, Beatriz Sánchez-Solana, Eva-María Monsalve, María-José M. Díaz-Guerra, Jorge Laborda, María-Luisa Nueda, Victoriano Baladrón
Publikováno v:
Cells, Vol 9, Iss 9, p 2032 (2020)
The NOTCH family of receptors and ligands is involved in numerous cell differentiation processes, including adipogenesis. We recently showed that overexpression of each of the four NOTCH receptors in 3T3-L1 preadipocytes enhances adipogenesis and mod
Externí odkaz:
https://doaj.org/article/d0097476754e430b8a7ea77a059333fb
Autor:
Marian E. Durkin, Dunrui Wang, Douglas R. Lowy, Brajendra K. Tripathi, Xiaolan Qian, Beatriz Sánchez-Solana
Publikováno v:
Cancer Research. 80:3568-3579
In advanced cancer, the RHOA GTPase is often active together with reduced expression of genes encoding Rho-specific GTPase-accelerating proteins (Rho-GAP), which negatively regulate RHOA and related GTPases. Here we used the The Cancer Genome Atlas d
Autor:
Douglas R. Lowy, Dunrui Wang, Beatriz Sánchez-Solana, Xiaolan Qian, Parthibane Velayoudame, Dhirendra K. Simanshu, Jairaj K. Acharya
Publikováno v:
Molecular Cancer
Molecular Cancer, Vol 20, Iss 1, Pp 1-18 (2021)
Molecular Cancer, Vol 20, Iss 1, Pp 1-18 (2021)
Background DLC1, a tumor suppressor gene that is downregulated in many cancer types by genetic and nongenetic mechanisms, encodes a protein whose RhoGAP and scaffolding activities contribute to its tumor suppressor functions. The role of the DLC1 STA
Autor:
Jorge Laborda, María José Díaz-Guerra, María-Milagros Rodríguez-Cano, María-Luisa Nueda, María-Julia González-Gómez, Victoriano Baladrón, Beatriz Sánchez-Solana, Eva-María Monsalve
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
The role of NOTCH signaling in adipogenesis is highly controversial, with data indicating null, positive or negative effects on this differentiation process. We hypothesize that these contradictory results could be due to the different global NOTCH s
Autor:
Beatriz Sánchez-Solana, Dominic Esposito, Marian E. Durkin, Andrew G. Stephen, Douglas R. Lowy, Dunrui Wang, Brajendra K. Tripathi, Alex G. Papageorge, Yucheng Gao, Timothy J. Waybright, Xiaolan Qian
Publikováno v:
Cancer Research. 80:2586-2586
While the Ras GTPases are frequently mutated, especially at codons 12, 13, or 61, the structurally related Rho GTPases, although they are implicated in tumor invasion and metastasis, are rarely mutated in solid tumors, except for diffuse gastric canc
Autor:
María José Díaz-Guerra, María-Milagros Rodríguez-Cano, Beatriz Sánchez-Solana, María-Julia González-Gómez, Jorge Laborda, María-Luisa Nueda, Victoriano Baladrón, Eva-María Monsalve
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-1 (2018)
Scientific Reports
Scientific Reports
The role of NOTCH signaling in adipogenesis is highly controversial, with data indicating null, positive or negative effects on this differentiation process. We hypothesize that these contradictory results could be due to the different global NOTCH s
Autor:
José J. García-Ramírez, María Luisa Nueda, María José Ruiz-Hidalgo, María Desamparados Ruvira, Jorge Laborda, Victoriano Baladrón, Samuel Rivero, Eva M. Monsalve, María José Díaz-Guerra, Beatriz Sánchez-Solana
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1813:1153-1164
The protein DLK2, highly homologous to DLK1, belongs to the EGF-like family of membrane proteins, which includes NOTCH receptors and their DSL-ligands. The molecular mechanisms by which DLK proteins regulate cell differentiation and proliferation pro
Autor:
Brajendra K. Tripathi, Marian E. Durkin, Beatriz Sánchez-Solana, Xiaolan Qian, Dunrui Wang, Douglas R. Lowy, Alex G. Papageorge
Publikováno v:
Cancer Research. 78:5522-5522
The tumor suppressor gene DLC1 encodes a multi-domain protein, including a Rho-GAP domain (Rho GTPase activating protein domain) that negatively regulates the activity of RhoA, RhoB, and RhoC, and has been hypothesized to be the basis of its tumor su
The EGF-like Protein dlk1 Inhibits Notch Signaling and Potentiates Adipogenesis of Mesenchymal Cells
Autor:
Victoriano Baladrón, Jorge Laborda, María-Ángeles Ballesteros, María-Luisa Nueda, Beatriz Sánchez-Solana
Publikováno v:
Journal of Molecular Biology. 367:1281-1293
The EGF-like homeotic gene Dlk1 appears to function as an inhibitor of adipogenesis. Overexpression of Dlk1 prevents adipogenesis of 3T3-L1 cells. Dlk1-deficient mice are obese; however, adipose tissue still develops in Fc-dlk1 transgenic mice, sugge
Autor:
Beatriz Sanchez-Solana, Dunrui Wang, Xiaolan Qian, Parthibane Velayoudame, Dhirendra K. Simanshu, Jairaj K. Acharya, Douglas R. Lowy
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-18 (2021)
Abstract Background DLC1, a tumor suppressor gene that is downregulated in many cancer types by genetic and nongenetic mechanisms, encodes a protein whose RhoGAP and scaffolding activities contribute to its tumor suppressor functions. The role of the
Externí odkaz:
https://doaj.org/article/a367e3987a09471bbf53fecd07797e4f