Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Beatriz Millare"'
Autor:
Lan Chen, Beatriz Millare, Jeremy Chen, Aaron Cooper, Natalie Bezman, Angela Boroughs, Suchismita Mohanty, David DeTomaso, Amy-Jo Casbon, Thomas J Gardner, Anzhi Yao, Ashley Cass, Alma Gomez, Manching Ku, Lionel Berthoin, Meng Lim, Azalea Ong, Vince Thomas, Nicholas Quant, Brian Hsu, Levi Gray-Rupp, W Nicholas Haining
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/5e4a90e7ee90474c9a89859560f13aa5
Autor:
Ivan Chan, Laura Lim, Irene Scarfò, Darrian Moskowitz, Beatriz Millare, Kevin Dang, Jeremy Chen, Nickolas Attanasio, Angela Boroughs, Michelle Nguyen, Suchismita Mohanty, Jenessa Smith, James Zhang, Jennifer McDevitt, Thomas J Gardner, Alma Gomez, Vince Thomas, Marvin Chew, Rakesh Sudhakah, Amanda Fearon, Vibhavari Sail, Stanley Zhou
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/a27f077956a146d6ba279e1956215f55
Autor:
Tony Muchamuel, R. Andrea Fan, Janet L. Anderl, Darrin J. Bomba, Henry W. B. Johnson, Eric Lowe, Brian B. Tuch, Dustin L. McMinn, Beatriz Millare, Christopher J. Kirk
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Zetomipzomib (KZR-616) is a selective inhibitor of the immunoproteasome currently undergoing clinical investigation in autoimmune disorders. Here, we characterized KZR-616 in vitro and in vivo using multiplexed cytokine analysis, lymphocyte activatio
Externí odkaz:
https://doaj.org/article/b8472904a1e148a78a2945fec4d80181
Autor:
Christopher Kirk, Jennifer Whang, Andrea Fan, Eric Lowe, Dustin McMinn, Beatriz Millare, Meera Rao
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/084b6f59a49e4906acef1c9da2333497
Autor:
Thomas J. Gardner, Adam Litterman, Brenal K. Singh, Luisa Silva, Mukund Hari, Stanley Zhou, Colin Tang, Sahil Joshi, John Gagnon, Oliver Takacsi-Nagy, Jason Hall, Hans Pope, James Zhang, Alma Gomez, Jeremy Chen, Suchismita Mohanty, Vince Thomas, Nicholas Quant, Beatriz Millare, Amy-Jo Casbon, Natalie Bezman, Levi Gray-Rupp, Angela C. Boroughs, W. Nicholas Haining
Publikováno v:
Cancer Research. 83:1768-1768
T cell exhaustion resulting from chronic antigen stimulation and immunosuppression in the tumor microenvironment (TME) limits CAR T efficacy in the solid tumor setting. We have previously shown that engineering therapeutic T cell products using CRISP
Autor:
Thomas J. Gardner, Beatriz Millare, Anzhi Yao, Ashley Cass, Suchismita Mohanty, Jeremy Chen, Alma Gomez, David DeTomaso, Manching Ku, Lionel Berthoin, Meng Lim, Azalea Ong, Vince Thomas, Nicholas Quant, Brian Hsu, Amy-Jo Casbon, Natalie Bezman, Aaron Cooper, Levi Gray-Rupp, Angela C. Boroughs, W. Nicholas Haining
Publikováno v:
Cancer Research. 83:4073-4073
Clinically effective adoptive T cell therapy for the treatment of solid tumors will require robust T cell expansion, persistence, and potency. The Janus-kinase signal transducer and activator of transcription (JAK-STAT) pathway governs T cell activat
Autor:
Beatriz Millare, Dustin McMinn, Jennifer A. Whang, Eric Lowe, Meera Rao, Andrea R. Fan, Christopher J. Kirk
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Many tumor cells escape immune cell clearance by overexpressing CD47, a multi-pass transmembrane protein, which binds signal regulatory protein α (SIRPα) on macrophages leading to decreased phagocytic activity. Blockade of CD47/SIRPα in
Autor:
Sean M. Carroll, Xiaomu Chen, Alexander Scholz, Norman M. Greenberg, May Sumi, Patricia Zuno-Mitchell, Kevin S. Williamson, Daniel Emerling, Gilson Baia, Felix Chu, David R. Minor, Jacob Glanville, Beatriz Millare, Jeremy Sokolove, Xiaobin Tang, Yann Chong Tan, Wayne Volkmuth, Amy Manning-Bog, Lawrence Steinman, Guy Cavet, Ngan Nguyen, Shuwei Jiang, Tito Serafini, Michael G Harbell, Dongkyoon Kim, Eldar Giladi, Danhui Zhang, Jeff DeFalco, William H. Robinson, Yvonne Leung, Gregg Espiritu Santo, Christine Dowd, Nicole Haaser
Publikováno v:
Clinical Immunology. 187:37-45
There is significant debate regarding whether B cells and their antibodies contribute to effective anti-cancer immune responses. Here we show that patients with metastatic but non-progressing melanoma, lung adenocarcinoma, or renal cell carcinoma exh
Autor:
Yu Qian, Jennifer A. Whang, Eric Lowe, Tony Muchamuel, Beatriz Millare, Henry Johnson, Janet L. Anderl, Jinhai Wang, Dustin McMinn, Christopher J. Kirk
Publikováno v:
Cancer Research. 81:323-323
Secreted and transmembrane (TM) proteins play key roles in malignant transformation and tumor growth. During translation, the majority of these proteins require translocation through the Sec61 protein complex into the endoplasmic reticulum (ER) for f
Autor:
Yu Qian, Jennifer A. Whang, Jing Jiang, Brian B. Tuch, Tony Muchamuel, Beatriz Millare, Christopher J. Kirk, Patricia Zuno, R. Andrea Fan, Dustin McMinn, Henry Johnson, Eric Lowe
Publikováno v:
Journal of Clinical Oncology. 38:3582-3582
3582 Background: Secreted and transmembrane proteins play key roles in malignant transformation and growth, including in autocrine growth factor expression, receptor oncogene signaling, and immune system evasion. Biogenesis of these proteins involves