CXCL4 suppresses tolerogenic immune signature of monocyte‐derived dendritic cells

Autor: Beatriz Malvar Fernandez, Weiyang Tao, Sandra C Silva-Cardoso, Marianne Boes, Timothy R D J Radstake, Aridaman Pandit

Publikováno v: European Journal of Immunology

RNA sequencing and DNA methylomic profiling were performed after differentiating monocytes for 6 days into moDCs with/without CXCL4 presence. We show that CXCL4 downregulates genes associated with tolerogenicity in DCs including C1Q. Expression profi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f2541e22c3c5efcbfbef64d80394db
https://doi.org/10.1002/eji.201948341

Angiopoietin-2 Promotes Inflammatory Activation in Monocytes of Systemic Sclerosis Patients

Autor: Wioleta Marut, Tiago Carvalheiro, Femke Bonte-Mineur, Jose M Pego-Reigosa, Beatriz Malvar-Fernandez, Carlos Rafael-Vidal, Timothy R D J Radstake, Maili Zimmermann, Maarten van der Kroef, Lorenzo Beretta, Samuel Garcia, Anneline C Hinrichs, Marc R. Kok, Ana P Lopes, Nila H. Servaas

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 9544, p 9544 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 24

Angiopoietin-2 (Ang-2), a ligand of the tyrosine kinase receptor Tie2, is essential for vascular development and blood vessel stability and is also involved in monocyte activation. Here, we examined the role of Ang-2 on monocyte activation in patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::923bd789c7b899285ec89dd16c72a52b
https://www.mdpi.com/1422-0067/21/24/9544

Author response for 'CXCL4 suppresses tolerogenic immune signature of monocyte‐derived dendritic cells'

Autor: Sandra C Silva-Cardoso, Marianne Boes, Weiyang Tao, Beatriz Malvar Fernandez, Aridaman Pandit, Timothy R D J Radstake

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db9eb2b37a021b5c44baab179878c9da
https://doi.org/10.1002/eji.201948341/v2/response1

OP0327 Cxcl4 drives fibrosis by promoting several key cellular and molecular processes

Autor: Ralph G. Tieland, S. de Jager, Robert Lafyatis, J.A. van Roon, M. van der Linden, Tiago Carvalheiro, A. Affandi, D.-J. Heijnen, Andrea Ottria, Barbara Giovannone, Maike A.D. Brans, Caroline Cheng, Beatriz Malvar-Fernandez, Judith J. de Haan, A. Kowalska, Cornelis P. J. Bekker, Trdj Radstake, Wioleta Marut, Maarten M. Brandt

Publikováno v: FRIDAY, 15 JUNE 2018.

Background Fibrosis, characterised by excessive accumulation of extracellular matrix (ECM) through myofibroblasts, is a leading cause of mortality worldwide1,2. Understanding the pathways involved in myofibroblasts activation is crucial to develop no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a4209ce654b3445165788a67e0ea96ba
https://doi.org/10.1136/annrheumdis-2018-eular.6351

Histone deacetylase 3 regulates the inflammatory gene expression programme of rheumatoid arthritis fibroblast-like synoviocytes

Autor: Bradley S. Ferguson, Timothy A. McKinsey, Paolo Mascagni, Samuel Garcia, Paul P. Tak, Pawel A. Kabala, Kris A. Reedquist, Gianluca Fossati, Iris M. van Baarsen, Chiara Angiolilli, Beatriz Malvar Fernandez, Aleksander M. Grabiec, Dominique Baeten

Publikováno v: Angiolilli, C, Kabala, P A, Grabiec, A, Van Baarsen, I M, Ferguson, B S, García, S, Malvar Fernandez, B, McKinsey, T A, Tak, P P, Fossati, G, Mascagni, P, Baeten, D L & Reedquist, K A 2016, ' Histone deacetylase 3 regulates the inflammatory gene expression programme of rheumatoid arthritis fibroblast-like synoviocytes ', Annals of the rheumatic diseases, vol. 76 . https://doi.org/10.1136/annrheumdis-2015-209064
Annals of the rheumatic diseases, 76(1), 277-285. BMJ Publishing Group
Annals of the Rheumatic Diseases

ObjectivesNon-selective histone deacetylase (HDAC) inhibitors (HDACi) have demonstrated anti-inflammatory properties in both in vitro and in vivo models of rheumatoid arthritis (RA). Here, we investigated the potential contribution of specific class

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e8895cab1f685a8ee1db74c06b2eb47
https://ruj.uj.edu.pl/xmlui/handle/item/54855