Výsledky vyhledávání - "Beatriz Lozano‐Torres"

Akademický článek

A renal clearable fluorogenic probe for in vivo β-galactosidase activity detection during aging and senolysis

Autor: Sara Rojas-Vázquez, Beatriz Lozano-Torres, Alba García-Fernández, Irene Galiana, Ana Perez-Villalba, Pablo Martí-Rodrigo, M. José Palop, Marcia Domínguez, Mar Orzáez, Félix Sancenón, Juan F. Blandez, Isabel Fariñas, Ramón Martínez-Máñez

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Abstract Accumulation of senescent cells with age leads to tissue dysfunction and related diseases. Their detection in vivo still constitutes a challenge in aging research. We describe the generation of a fluorogenic probe (sulfonic-Cy7Gal) based on

Externí odkaz: https://doaj.org/article/1498936e271e4859a089a88d0502ed20

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Akademický článek

Pharmacological senolysis reduces doxorubicin-induced cardiotoxicity and improves cardiac function in mice

Autor: Araceli Lérida-Viso, Alejandra Estepa- Fernández, Ángela Morellá-Aucejo, Beatriz Lozano-Torres, María Alfonso, Juan F. Blandez, Viviana Bisbal, Pilar Sepúlveda, Alba García-Fernández, Mar Orzáez, Ramón Martínez-Máñez

Publikováno v: Pharmacological Research, Vol 183, Iss , Pp 106356- (2022)

Many anticancer agents used in clinics induce premature senescence in healthy tissues generating accelerated aging processes and adverse side-effects in patients. Cardiotoxicity is a well-known limiting factor of anticancer treatment with doxorubicin

Externí odkaz: https://doaj.org/article/69036e5930d14f0f8dda477cfa16e7ce

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Akademický článek

A versatile drug delivery system targeting senescent cells

Autor: Daniel Muñoz‐Espín, Miguel Rovira, Irene Galiana, Cristina Giménez, Beatriz Lozano‐Torres, Marta Paez‐Ribes, Susana Llanos, Selim Chaib, Maribel Muñoz‐Martín, Alvaro C Ucero, Guillermo Garaulet, Francisca Mulero, Stephen G Dann, Todd VanArsdale, David J Shields, Andrea Bernardos, José Ramón Murguía, Ramón Martínez‐Máñez, Manuel Serrano

Publikováno v: EMBO Molecular Medicine, Vol 10, Iss 9, Pp 1-18 (2018)

Abstract Senescent cells accumulate in multiple aging‐associated diseases, and eliminating these cells has recently emerged as a promising therapeutic approach. Here, we take advantage of the high lysosomal β‐galactosidase activity of senescent

Externí odkaz: https://doaj.org/article/d67df62499c14123a2c81e830cc433e4

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Boosting Protein Encapsulation through Lewis-Acid-Mediated Metal–Organic Framework Mineralization: Toward Effective Intracellular Delivery

Autor: Jesús Cases Díaz, Beatriz Lozano-Torres, Mónica Giménez-Marqués

Publikováno v: Cases Diaz, J., Lozano-Torres, B., & Giménez-Marqués, M. (2022). Boosting Protein Encapsulation through Lewis-Acid-Mediated Metal–Organic Framework Mineralization: Toward Effective Intracellular Delivery. Chemistry of Materials, 34 (17), 7817-7827.

Encapsulation of biomolecules using metal–organic frameworks (MOFs) to form stable biocomposites has been demonstrated to be a valuable strategy for their preservation and controlled release, which has been however restricted to specific electrosta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::850134471ff7d4eee7d2430f520b4d23
https://doi.org/10.1021/acs.chemmater.2c01338

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β-Galactosidase-Activatable Nile Blue-Based NIR Senoprobe for the Real-Time Detection of Cellular Senescence

Autor: Beatriz Lozano-Torres, Alba García-Fernández, Marcia Domínguez, Félix Sancenón, Juan F. Blandez, Ramón Martínez-Máñez

Publikováno v: Analytical chemistry.

Cellular senescence is a stable cell cycle arrest in response to stress or other damage stimuli to maintain tissue homeostasis. However, the accumulation of senescent cells can lead to the progression of various senescence-related disorders. In this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03f3244a7cc0d4bc1260211bb9c98f99
https://pubmed.ncbi.nlm.nih.gov/36580602

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Chromo-fluorogenic probes for β-galactosidase detection

Autor: Beatriz Lozano-Torres, Ramón Martínez-Máñez, Félix Sancenón, Juan F. Blandez

Publikováno v: ANALYTICAL AND BIOANALYTICAL CHEMISTRY
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
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RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)

[EN] beta-Galactosidase (beta-Gal) is a widely used enzyme as a reporter gene in the field of molecular biology which hydrolyzes the beta-galactosides into monosaccharides. beta-Gal is an essential enzyme in humans and its deficiency or its overexpre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4defc7346f81274ce36a418e089b40f
https://doi.org/10.1007/s00216-020-03111-8

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Electro-responsive films containing voltage responsive gated mesoporous silica nanoparticles grafted onto PEDOT-based conducting polymer

Autor: Ramón Martínez-Máñez, Alba García-Fernández, María D. Marcos, Javier Monreal-Trigo, Miguel Alcañiz, Beatriz Lozano-Torres, Juan F. Blandez, Jorge E. Collazos-Castro, Juan Soto, Félix Sancenón

Publikováno v: JOURNAL OF CONTROLLED RELEASE
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)

[EN] The characteristics and electromechanical properties of conductive polymers together to their biocompatibility have boosted their application as a suitable tool in regenerative medicine and tissue engineering. However, conducting polymers as dru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::055c9c6767371bb84e603a66f95c92cf
https://doi.org/10.1016/j.jconrel.2020.04.048

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Preclinical antitumor efficacy of senescence-inducing chemotherapy combined with a nanoSenolytic

Autor: Irene Galiana, Mar Orzáez, Mónica Sancho, María Alfonso, Viviana Bisbal, Beatriz Lozano-Torres, Ramón Martínez-Máñez, Manuel Serrano, Andrea Bernardos

Publikováno v: RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname

[EN] The induction of senescence produces a stable cell cycle arrest in cancer cells, thereby inhibiting tumor growth; however, the incomplete immune cell-mediated clearance of senescent cells may favor tumor relapse, limiting the long-term anti-tumo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6f4f15c2b94a49fd019c4e6cc50009a
https://doi.org/10.1016/j.jconrel.2020.04.045

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Lipofuscin labeling through biorthogonal strain-promoted azide-alkyne cycloaddition for the detection of senescent cells

Autor: Beatriz Lozano‐Torres, Juan F. Blandez, Alba García‐Fernández, Félix Sancenón, Ramón Martínez‐Máñez

Publikováno v: FEBS Journal
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
instname
FEBS JOURNAL
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe

[EN] A new method for senescent cell detection is described, which is based on lipofuscin labeling with a fluorescent reporter through a biorthogonal strain-promoted azide-alkyne cycloaddition. The sensing protocol involves a first step where the int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f02fec79caf5e7ba41e813cca55f62c4
https://fundanet.cipf.es/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3924

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